International Journal of Cardiology
Volume 76, Issue 2 , Pages 117-122, November 2000

Leptin serum levels in cachectic heart failure patients:

Relationship with tumor necrosis factor-α system

  • Gerasimos S Filippatos, MD

      Affiliations

    • First Department of Cardiology, Evangelismos Hospital, Athens, Greece
    • Corresponding Author InformationCorresponding author. Ambelokipi, 28 Doukissis Plakentias Street, 11523 Athens, Greece. Tel.: +30-1-6745-222; fax: 30-1-7218-025
    • ,
  • Karmelos Tsilias, MD

      Affiliations

    • First Department of Cardiology, Evangelismos Hospital, Athens, Greece
    • ,
  • Koula Venetsanou, BSc

      Affiliations

    • Athens University School of Nursing ICU, Kifisia, Athens, Greece
    • ,
  • Elias Karambinos, MD

      Affiliations

    • First Department of Cardiology, Evangelismos Hospital, Athens, Greece
    • ,
  • Dimitris Manolatos, MD

      Affiliations

    • Second Department of Cardiology, Evangelismos Hospital, Athens, Greece
    • ,
  • Athanasios Kranidis, MD

      Affiliations

    • First Department of Cardiology, Evangelismos Hospital, Athens, Greece
    • ,
  • John Antonellis, MD

      Affiliations

    • Department of Invasive Cardiology, Evangelismos Hospital, Athens, Greece
    • ,
  • Fotis Kardaras, MD

      Affiliations

    • Second Department of Cardiology, Evangelismos Hospital, Athens, Greece
    • ,
  • Lambros Anthopoulos, MD

      Affiliations

    • First Department of Cardiology, Evangelismos Hospital, Athens, Greece
    • ,
  • George Baltopoulos, MD

      Affiliations

    • Athens University School of Nursing ICU, Kifisia, Athens, Greece

Received 16 September 1999; received in revised form 18 May 2000; accepted 13 June 2000.

Abstract 

Cachexia is a strong predictor for mortality in patients with congestive heart failure. To investigate the role of leptin and regulators of apoptosis in cardiac cachexia we compared leptin concentrations and their relation to the TNF system, interleukin 1-beta (IL-1b), and soluble Fas in patients with heart failure with and without cachexia. Patients with cardiac cachexia have increased levels of interleukin-1b compared to non-cachectic heart failure patients [mean(S.E.)=1.11(0.62) vs. 0.02(0.02), P=0.01] and decreased concentrations of leptin [10.79(3.93) vs. 23.24 (8.35), P=0.1]. Leptin levels correlate with TNF-RI in cachectic heart failure patients (r=0.58, P=0.018). The TNF-RI levels were also correlated with Fas, both in all the patients taken together (r=0.5, P=0.006) and in those with cachexia (r=0.52, P=0.036). Our data indicate that more prospective studies are needed to clarify the role of leptin in the pathophysiology of heart failure cachexia.

Keywords:  Carchiac cachexia, Leptin, Tumor necrosis factor-α

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PII: S0167-5273(00)00397-1

International Journal of Cardiology
Volume 76, Issue 2 , Pages 117-122, November 2000

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