Myocardial infarction after aspirin cessation in stable coronary artery disease patients

Received 29 June 2000; accepted 13 September 2000.

Abstract

Discontinuation of chronic aspirin therapy in stable coronary artery disease patients may lead to acute myocardial infarction within 10 days of withdrawal as a consequence of the progressive recovery of the platelet cyclooxygenase activity which exposes to a rebound effect leading to acute coronary thrombosis.

Keywords: Myocardial infarction, Aspirin, Platelets

a Department of Cardiology, Centre Hospitalier Universitaire Pitié-Salpétrière, 47 Boulevard de l’Hôpital, 75013 Paris, France

b Department of Cardiology, Centre Hospitalier Universitaire Bichat, Rue Huchard, 75018 Paris, France

Corresponding author. Tel.: +33-1-4217-6742; fax: +33-1-4217-6856

PII: S0167-5273(00)00399-5

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