International Journal of Cardiology
Volume 127, Issue 1 , Pages 46-50 , 23 June 2008

Platelet glycoprotein IIb HPA-3 polymorphism and acute coronary syndromes

  • John Lekakis

      Affiliations

    • Department of Cardiology, Attikon University Hospital, Athens University, Greece
    • Corresponding Author InformationCorresponding author. 12 Iridanou str, 115 28 Athens, Greece. Tel.: +30 210 7299200; fax: +30 210 7299201.
    • ,
  • Sofia Bisti

      Affiliations

    • Department of Microbiology, Hellenic Pasteur Institute, Athens, Greece
    • ,
  • Elias Tsougos

      Affiliations

    • Department of Cardiology, Attikon University Hospital, Athens University, Greece
    • ,
  • Athanasios Papathanassiou

      Affiliations

    • Department of Cardiology, University of Ioannina, Greece
    • ,
  • Nikolaos Dagres

      Affiliations

    • Department of Cardiology, Attikon University Hospital, Athens University, Greece
    • ,
  • Ignatios Ikonomidis

      Affiliations

    • Department of Cardiology, Attikon University Hospital, Athens University, Greece
    • ,
  • Ekaterini Soteriadou

      Affiliations

    • Department of Microbiology, Hellenic Pasteur Institute, Athens, Greece
    • ,
  • Alexandros D. Tselepis

      Affiliations

    • Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, Greece
    • ,
  • John Goudevenos

      Affiliations

    • Department of Cardiology, University of Ioannina, Greece
    • ,
  • Dimitris Th. Kremastinos

      Affiliations

    • Department of Cardiology, Attikon University Hospital, Athens University, Greece

Received 25 July 2006 ,Revised 30 March 2007 ,Accepted 4 April 2007.

References 

  1. Shah PK. Pathophysiology of coronary thrombosis: role of plaque rupture and erosion. Prog Cardiovasc Dis. 2002;44:357–368
  2. Meisel C, Lopez JA, Stangl K. Role of platelet glycoprotein polymorphisms in cardiovascular diseases. Arch Pharmacol. 2004;369:38–54
  3. Newman PJ. Alloimune thrombocytopenias. In:  Loscalzo JS,  Chafer AI editor. Thrombosis and hemorrhage. Boston: Blackwell Scientific; 1994;p. 529–543
  4. Weiss EJ, Bray PF, Tayback M, et al. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N Engl J Med. 1996;334:1090–1094
  5. Goodall AH, Curzen N, Panesar M, et al. Increased binding of fibrinogen to glycoprotein IIIa-Proline33(HPA-1b, PlA2, Zwb) positive platelets in patients with cardiovascular disease. Eur Heart J. 1999;20:742–747
  6. Bottiger C, Kastrati A, Koch W, et al. HPA-1 and HPA-3 polymorphisms of the platelet fibrinogen receptor and coronary artery disease and myocardial infarction. Thromb Haemost. 2000;83:559–562
  7. Carter AM, Catto AJ, Bamford JM, Grant PJ. Association of the platelet glycoprotein IIb HPA-3 polymorphism with survival after acute ischemic stroke. Stroke. 1999;30:2606–2611
  8. Bottiger C, Kastrati A, Koch W, et al. Polymorphism of platelet glycoprotein IIb and risk of thrombosis and restenosis after coronary stent placement. Am J Cardiol. 1999;84:987–991
  9. Reiner AP, Schwartz SM, Kumar PN, et al. Platelet glycoprotein IIb polymorphism, traditional risk factors and non-fatal myocardial infarction in young women. Br J Haematol. 2001;112:632–636
  10. The Joint European Society of Cardiology/American College of Cardiology Committee. Myocardial infarction redefined — a consensus document of The Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000;36:959–969
  11. Lyou JY, Chen YJ, Hu HY, Lin JS, Tzeng CH. PCR with sequence-specific primer-based simultaneous genotyping of human platelet antigen-1 to -13w. Transfusion. 2002;42:1089–1095
  12. Borna C, Lazarowski E, van Heusden C, Öhlin H, Erlinge D. Resistance to aspirin is increased by ST-elevation myocardial infarction and correlates with adenosine diphosphate levels. Thrombosis J. 2005;3:10
  13. Michelson AD, Furman MI, Goldschmidt-Clermont P, et al. Platelet GPIIIa PlA polymorphism display different sensitivities to agonists. Circulation. 2000;101:1013–1018
  14. Feng D, Lindpaintner K, Larson MG, et al. Increased platelet aggregability associated with platelet GPIIIa PlA2 polymorphisms: the Framingham Offspring Study. Arterioscler Thromb Vasc Biol. 1999;19:1142–1147
  15. Mikkelson J, Perola M, Laippala P, et al. Glycoprotein IIIa PlA polymorphism associates with progression of coronary artery disease and with myocardial infarction in an autopsy series of middle-aged men who died suddenly. Arterioscler Thromb Vasc Biol. 1999;19:2573–2578
  16. Ridker PM, Henneken CH, Schmitz C, Stampfer MJ, Lindpainter K. PlA1/PlA2 of platelet glycoprotein IIIa and risks of myocardial infarction, stroke, and venous thrombosis. Lancet. 1997;349:385–388
  17. Hato T, Minamoto Y, Fukuyama T, Fujita S. Polymorphism of HPA-1 through 6 on platelet membrane glycoprotein receptors are not a genetic risk factor for myocardial infarction in the Japanese population. Am J Cardiol. 1997;80:1222–1224
  18. Reiner AP, Kumar PN, Scharrz SM, et al. Genetic variants of platelet glycoprotein receptors and risk of stroke in young women. Stroke. 2000;31:1628–1633
  19. O'Donnell CJ, Larson MG, Feng D, et al. Genetic and environmental contributions to platelet aggregation. The Framingham Heart Study. Circulation. 2001;103:3051–3056
  20. Bray PF, Michelson AD, Furman MI, et al. Correlating genetic variations in adhesive receptors with platelet function. Blood. 1999;94:216

PII: S0167-5273(07)00927-8

doi: 10.1016/j.ijcard.2007.04.039

International Journal of Cardiology
Volume 127, Issue 1 , Pages 46-50 , 23 June 2008

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