International Journal of Cardiology
Volume 127, Issue 1 , Pages 57-63 , 23 June 2008

Late ventricular remodeling in non-reperfused acute myocardial infarction in humans is predicted by angiotensin II type 1 receptor density on blood platelets

  • Michał Mączewski

      Affiliations

    • Department of Clinical Physiology, Medical Centre of Postgraduate Education, Warszawa, Poland
    • Department of Cardiology, Wolski Hospital, Warszawa, Poland
    • Corresponding Author InformationCorresponding author. Department of Clinical Physiology, Medical Centre of Postgraduate Education, Marymoncka 99, 01-813 Warszawa, Poland. Tel.: +48 22 5693 841; fax: +48 22 5693 712.
  • ,
  • Marcin Borys

      Affiliations

    • Department of Cardiology, Wolski Hospital, Warszawa, Poland
  • ,
  • Paweł Kacprzak

      Affiliations

    • Department of Cardiology, Wolski Hospital, Warszawa, Poland
  • ,
  • Tomasz Gdowski

      Affiliations

    • Department of Cardiology, Wolski Hospital, Warszawa, Poland
  • ,
  • Marek Kowalewski

      Affiliations

    • Department of Cardiology, Wolski Hospital, Warszawa, Poland
  • ,
  • Dariusz Wojciechowski

      Affiliations

    • Department of Cardiology, Wolski Hospital, Warszawa, Poland

Received 17 July 2006 ,Revised 12 April 2007 ,Accepted 23 April 2007.

References 

  1. Sutton MG, Sharpe N. Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation. 2000;101:2981–2988
  2. White HD, Norris RM, Brown MA, Brandt PW, Whitlock RM, Wild CJ. Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction. Circulation. 1987;76:44–51
  3. Pfeffer MA, McMurray JJV, Velazquez EJ, et al. The Valsartan in Acute Myocardial Infarction Trial Investigators. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med. 2003;349:1893–1906
  4. Nickenig G, Harrison DG. The AT1-type angiotensin receptor in oxidative stress and atherogenesis: part II: AT1 receptor regulation. Circulation. 2002;105:530–536
  5. Yousufuddin M, Haji S, Starling RC, et al. Cardiac angiotensin II receptors as predictors of transplant coronary artery disease following heart transplantation. Eur Heart J. 2004;25:377–385
  6. Tiret L, Bonnardeaux A, Poirier O, et al. Synergistic effects of angiotensin-converting enzyme and angiotensin-II type 1 receptor gene polymorphisms on risk of myocardial infarction. Lancet. 1994;344:910–913
  7. Mączewski M, Borys M, Kacprzak P, Gdowski T, Wojciechowski D. Angiotensin II AT(1) receptor density on blood platelets predicts early left ventricular remodelling in non-reperfused acute myocardial infarction in humans. Eur J Heart Fail. 2006;8:173–178
  8. Nickenig G, Baumer AT, Temur Y, Kebben D, Jockenhovel F, Bohm M. Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men. Circulation. 1999;100:2131–2134
  9. Moore TJ, Williams GH. Angiotensin II receptors on human platelets. Circ Res. 1982;51:314–320
  10. Devereux RB, Reichek N. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation. 1977;55:613–618
  11. Licka M, Zimmermann R, Zehelein J, Dengler TJ, Katus HA, Kubler W. Troponin,T concentrations 72 hours after myocardial infarction as a serological estimate of infarct size. Heart. 2002;87:520–524
  12. Timmermans PB, Wong PC, Chiu AT, et al. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev. 1993;45:205–251
  13. Peach MJ. Renin–angiotensin system: biochemistry and mechanisms of action. Physiol Rev. 1977;57:313–370
  14. Gunther S, Gimbrone MA, Alexander RW. Regulation by angiotensin II of its receptors in resistance blood vessels. Nature. 1980;287:230–232
  15. Yang BC, Phillips MI, Mohuczy D, et al. Increased angiotensin II type 1 receptor expression in hypercholesterolemic atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol. 1998;18:1433–1439
  16. Meggs LG, Coupet J, Huang H, et al. Regulation of angiotensin II receptors on ventricular myocytes after myocardial infarction in rats. Circ Res. 1993;72:1149–1162
  17. Aguilera G, Catt K. Regulation of vascular angiotensin II receptors in the rat during altered sodium intake. Circ Res. 1981;49:751–758
  18. Sigurdsson A, Held P, Swedberg K. Short- and long-term neurohormonal activation following acute myocardial infarction. Am Heart J. 1993;126:1068–1076
  19. Serneri GGN, Boddi M, Cecioni I, et al. Cardiac angiotensin II formation in the clinical course of heart failure and its relationship with left ventricular function. Circ Res. 2001;88:961–968
  20. Leenen FH, Skarda V, Yuan B, White R. Changes in cardiac ANG II postmyocardial infarction in rats: effects of nephrectomy and ACE inhibitors. Am J Physiol Heart Circ Physiol. 1999;276:H317–H325
  21. Wang TD, Wu CC, Chen WJ, et al. Dyslipidemias have a detrimental effect on left ventricular systolic function in patients with a first acute myocardial infarction. Am J Cardiol. 1998;81:531–537
  22. Mączewski M, Mączewska J. Hypercholesterolemia exacerbates ventricular remodeling in the rat model of myocardial infarction. J Card Fail. 2006;12:399–405
  23. Carrabba N, Valenti R, Parodi G, Santoro GM, Antoniucci D. Left ventricular remodeling and heart failure in diabetic patients treated with primary angioplasty for acute myocardial infarction. Circulation. 2004;110:1974–1979
  24. Wassmann S, Laufs U, Baumer AT, et al. Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase. Mol Pharmacol. 2001;59:646–654
  25. de Lemos JA, Blazing MA, Wiviott SD, et al. For the at. early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial. JAMA. 2004;292:1307–1316
  26. Kiliszek M, Mączewski M, Styczyński G, et al. Low-density lipoprotein reduction by simvastatin is accompanied by angiotensin II type 1 receptor downregulation, reduced oxidative stress, and improved endothelial function in patients with stable coronary artery disease. Coron Artery Dis. 2007;18:201–209

PII: S0167-5273(07)01026-1

doi: 10.1016/j.ijcard.2007.04.074

International Journal of Cardiology
Volume 127, Issue 1 , Pages 57-63 , 23 June 2008