International Journal of Cardiology
Volume 127, Issue 1 , Pages 40-45 , 23 June 2008

Value of right ventricular dysfunction for prognosis in pulmonary embolism

  • Ling Zhu

      Affiliations

    • Department of Respiratory Medicine, Shandong Provincial Hospital, Shandong University, Jinan, China
    • Now studying in Beijing Chao-yang Hospital.
    • ,
  • Yuanhua Yang

      Affiliations

    • Beijing Institute of Respiratory Medicine, Beijing Chao-yang Hospital, Capital University of Medical Sciences, Beijing 100020, China
    • ,
  • Yafeng Wu

      Affiliations

    • Department of Ultrasonography, Beijing Chao-yang Hospital, Capital University of Medical Sciences, Beijing, China
    • ,
  • Zhenguo Zhai

      Affiliations

    • Beijing Institute of Respiratory Medicine, Beijing Chao-yang Hospital, Capital University of Medical Sciences, Beijing 100020, China
    • ,
  • Chen Wang

      Affiliations

    • Beijing Institute of Respiratory Medicine, Beijing Chao-yang Hospital, Capital University of Medical Sciences, Beijing 100020, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 10 85231893; fax: +86 10 65060167.

Received 3 July 2006 ,Revised 24 June 2007 ,Accepted 30 June 2007.

References 

  1. Goldhaber SZ, Elliott CG. Acute pulmonary embolism, Part II: risk stratification, treatment, and prevention. Circulation. 2003;108:2834–2838
  2. Grifoni S, Olivotto I, Cecchni P, et al. Short-term outcome of patients with acute pulmonary embolism, normal blood pressure, and echocardiographic right ventricular dysfunction. Circulation. 2000;101:2817–2822
  3. Goldhaber SZ, Haire WD, Feldstein ML, et al. Alteplase versus heparin in acute pulmonary embolism: randomized trial assessing right ventricular function and pulmonary perfusion. Lancet. 1993;341:507–511
  4. Konstantinides S, Geibel A, Olschewski M, et al. Association between thrombolytic treatment and the prognosis of hemodynamically stable patients with major pulmonary embolism: results of a multicenter registry. Circulation. 1997;96:882–888
  5. Konstantinides S, Geibel A, Heusel G, Heritz F, Kasper W. For the management strategies and prognosis of pulmonary embolism-3 trial investigators. Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism. N Engl J Med. 2002;347:1143–1150
  6. Kreit JW. The impact of right ventricular dysfunction on the prognosis and therapy of normotensive patients with pulmonary embolism. Chest. 2004;125:1539–1545
  7. Binder L, Pieske B, Olschewski M, et al. N-terminal pro-brain natriuretic peptide or troponin testing followed by echocardiography for risk stratification of acute pulmonary embolism. Circulation. 2005;112:1573–1579
  8. Kasper W, Konstantinides S, Geibel A, et al. Management strategies and determinates of outcome in acute major pulmonary embolism: results of a multi-center registry. J Am Coll Cardiol. 1997;30:1165–1171
  9. Kasper W, Konstantinides S, Geibel A, Tiede N, Krause T, Just H. Prognostic significance of right ventricular afterload stress detected by echocardiography in patients with clinically suspected pulmonary embolism. Heart. 1997;77:346–349
  10. Lualdi JC, Goldhaber SZ. Right ventricular dysfunction after acute pulmonary embolism: pathophysiologic factors, detection, and therapeutic implications. Am Heart J. 1995;130:1276–1282
  11. Ribeiro A, Lindmarker P, Juhlin-Dannfelt A, Johnsson H, Jorfeldt L. Echocardiography Doppler in pulmonary embolism: right ventricular dysfunction as a predictor of mortality. Am Heart J. 1997;134:479–487
  12. Wolfe MW, Lee RT, Feldstein ML, Parker JA, Come PC, Goldhaber SZ. Prognostic significance of right ventricular hypokinesis and perfusion lung scan defects in pulmonary embolism. Am Heart J. 1994;127:1371–1375
  13. Janata K, Holzer M, Laggner AN, Mullner M. Cardiac troponin T in the severity assessment of patients with pulmonary embolism: cohort study. BMJ. 2003;326:312–313
  14. Kucher N, Wallmann D, Carone A. Incremental prognostic value of troponin I and echocardiography in patients with acute pulmonary embolism. Eur Heart J. 2003;24:1651–1656
  15. Pruszczyk P, Bochowicz A, Torbicki A, et al. Cardiac troponin T monitoring identifies high-risk group of normotensive patients with acute pulmonary embolism. Chest. 2003;123:1947–1952
  16. Mansencal N, Joseph T, Vieillard BA, et al. Comparison of different echocardiographic indexes secondary to right ventricular obstruction in acute pulmonary embolism. Am J Cardiol. 2003;92:116–119
  17. Kucher N, Rossi E, De RM, Goldhaber SZ. Prognostic role of echocardiography among patients with acute pulmonary embolism and a systolic arterial pressure of 90 mm Hg or higher. Arch Intern Med. 2005;165:1777–1781
  18. Casazza F, Bongarzoni A, Capozi A, Agostoni O. Regional right ventricular dysfunction in acute pulmonary embolism and right ventricular infarction. Eur J Echocardiogr. 2005;6:11–14

☆ This study was supported by a grant (2004BA703B07) from National Project of the Diagnosis and Treatment Strategies for Pulmonary Thromboembolism in China (NATSPUTE).

PII: S0167-5273(07)01258-2

doi: 10.1016/j.ijcard.2007.06.093

International Journal of Cardiology
Volume 127, Issue 1 , Pages 40-45 , 23 June 2008

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