International Journal of Cardiology
Volume 125, Issue 2 , Pages 166-171 , 10 April 2008

Peak VO2 in elderly patients with heart failure

  • Lars H. Lund

      Affiliations

    • Division of Cardiology and Medicine, Karolinska Institute and Karolinska University Hospital, 171 76 Stockholm, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46 8 51770000; fax: +46 8 311044.
  • ,
  • Donna M. Mancini

      Affiliations

    • Center for Advanced Cardiac Care, Columbia University College of Physicians & Surgeons, New York, USA

References 

  1. Lund LH, Mancini D. Heart failure in women. Med Clin North Am. 2004;88:1321–45;xii
  2. American Heart Association. Heart disease and stroke statistics—2003 update. Available at: http://www.americanheart.org/presenter.jhtml?identifier=1928 and http://www.zamericanheart.org/presenter.jhtml?identifier=2007. 2003.
  3. Zipes, DP, Braunwald E. Braunwald's heart disease: a textbook of cardiovascular medicine. Philadelphia, Pa.: W.B. Saunders, 2005:xxi, 2183, [75] p.
  4. Lakatta EG. Cardiovascular regulatory mechanisms in advanced age. Physiol Rev. 1993;73:413–67
  5. Masoro EJ, American Physiological Society (1887-). Aging. New York: Published for the American Physiological Society by Oxford University Press, 1995:x, 681 p.
  6. Cunningham DA, Nancekievill EA, Paterson DH, Donner AP, Rechnitzer PA. Ventilation threshold and aging. J Gerontol. 1985;40:703–7
  7. Posner JD, Gorman KM, Klein HS, Cline CJ. Ventilatory threshold: measurement and variation with age. J Appl Physiol. 1987;63:1519–25
  8. Singh MA. Exercise comes of age: rationale and recommendations for a geriatric exercise prescription. J Gerontol A Biol Sci Med Sci. 2002;57:M262–82
  9. Tanaka H, Monahan KD, Seals DR. Age-predicted maximal heart rate revisited. J Am Coll Cardiol. 2001;37:153–6
  10. Hollenberg M, Yang J, Haight TJ, Tager IB. Longitudinal changes in aerobic capacity: implications for concepts of aging. J Gerontol A Biol Sci Med Sci. 2006;61:851–8
  11. Holloszy JO. The biology of aging. Mayo Clin Proc. 2000;75(Suppl:S3-8):discussion S8-9
  12. Weisman IM, Zeballos RJ. Clinical exercise testing. Basel: Karger; 2002;
  13. Butler J, Chomsky DB, Wilson JR. Pulmonary hypertension and exercise intolerance in patients with heart failure. J Am Coll Cardiol. 1999;34:1802–6
  14. Smith AA, Cowburn PJ, Parker ME, et al. Impaired pulmonary diffusion during exercise in patients with chronic heart failure. Circulation. 1999;100:1406–10
  15. Buller NP, Poole-Wilson PA. Mechanism of the increased ventilatory response to exercise in patients with chronic heart failure. Br Heart J. 1990;63:281–3
  16. Okita K, Nishijima H, Yonezawa K, et al. Skeletal muscle metabolism in maximal bicycle and treadmill exercise distinguished by using in vivo metabolic freeze method and phosphorus-31 magnetic resonance spectroscopy in normal men. Am J Cardiol. 1998;81:106–9
  17. Chati Z, Zannad F, Jeandel C, et al. Physical deconditioning may be a mechanism for the skeletal muscle energy phosphate metabolism abnormalities in chronic heart failure. Am Heart J. 1996;131:560–6
  18. Mancini DM, Walter G, Reichek N, et al. Contribution of skeletal muscle atrophy to exercise intolerance and altered muscle metabolism in heart failure. Circulation. 1992;85:1364–73
  19. Clark AL, Poole-Wilson PA, Coats AJ. Exercise limitation in chronic heart failure: central role of the periphery. J Am Coll Cardiol. 1996;28:1092–102
  20. Chua TP, Ponikowski PP, Harrington D, Chambers J, Coats AJ. Contribution of peripheral chemoreceptors to ventilation and the effects of their suppression on exercise tolerance in chronic heart failure. Heart. 1996;76:483–9
  21. Vescovo G, Volterrani M, Zennaro R, et al. Apoptosis in the skeletal muscle of patients with heart failure: investigation of clinical and biochemical changes. Heart. 2000;84:431–7
  22. Duscha BD, Kraus WE, Keteyian SJ, et al. Capillary density of skeletal muscle: a contributing mechanism for exercise intolerance in class II-III chronic heart failure independent of other peripheral alterations. J Am Coll Cardiol. 1999;33:1956–63
  23. Tsutsui H, Ide T, Hayashidani S, et al. Enhanced generation of reactive oxygen species in the limb skeletal muscles from a murine infarct model of heart failure. Circulation. 2001;104:134–6
  24. Mancini DM, Coyle E, Coggan A, et al. Contribution of intrinsic skeletal muscle changes to 31P NMR skeletal muscle metabolic abnormalities in patients with chronic heart failure. Circulation. 1989;80:1338–46
  25. De Sousa E, Veksler V, Bigard X, Mateo P, Ventura-Clapier R. Heart failure affects mitochondrial but not myofibrillar intrinsic properties of skeletal muscle. Circulation. 2000;102:1847–53
  26. Walsh JT, Andrews R, Johnson P, Phillips L, Cowley AJ, Kinnear WJ. Inspiratory muscle endurance in patients with chronic heart failure. Heart. 1996;76:332–6
  27. Meyer FJ, Borst MM, Zugck C, et al. Respiratory muscle dysfunction in congestive heart failure: clinical correlation and prognostic significance. Circulation. 2001;103:2153–8
  28. Havranek EP, Masoudi FA, Westfall KA, Wolfe P, Ordin DL, Krumholz HM. Spectrum of heart failure in older patients: results from the National Heart Failure project. Am Heart J. 2002;143:412–7
  29. Braunstein JB, Anderson GF, Gerstenblith G, et al. Noncardiac comorbidity increases preventable hospitalizations and mortality among Medicare beneficiaries with chronic heart failure. J Am Coll Cardiol. 2003;42:1226–33
  30. Gibbons RJ, Balady GJ, Bricker JT, et al. ACC/AHA 2002 guideline update for exercise testing: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). Circulation. 2002;106:1883–92
  31. Hunt SA, Abraham WT, Chin MH, et al. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation. 2005;112:e154–235
  32. Swedberg K, Cleland J, Dargie H, et al. Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Eur Heart J. 2005;26:1115–40
  33. Mehra MR, Kobashigawa J, Starling R, et al. Listing criteria for heart transplantation: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates—2006. J Heart Lung Transplant. 2006;25:1024–42
  34. Mancini D, LeJemtel TH. Is ventilatory classification preferable to peak oxygen consumption for risk stratification in heart failure?. Circulation. 2007;115:2376–8
  35. Green P, Lund LH, Mancini D. Comparison of peak exercise oxygen consumption and the Heart Failure Survival Score for predicting prognosis in women versus men. Am J Cardiol. 2007;99:399–403
  36. Guazzi M, Agostoni P, Matturri M, Pontone G, Guazzi MD. Pulmonary function, cardiac function, and exercise capacity in a follow-up of patients with congestive heart failure treated with carvedilol. Am Heart J. 1999;138:460–7
  37. Lund LH, Aaronson KD, Mancini DM. Predicting survival in ambulatory patients with severe heart failure on beta-blocker therapy. Am J Cardiol. 2003;92:1350–4
  38. Arena R, Myers J, Abella J, et al. Development of a ventilatory classification system in patients with heart failure. Circulation. 2007;115:2410–7
  39. Guazzi M, Myers J, Arena R. Cardiopulmonary exercise testing in the clinical and prognostic assessment of diastolic heart failure. J Am Coll Cardiol. 2005;46:1883–90
  40. Mancini DM, Eisen H, Kussmaul W, Mull R, Edmunds LH, Wilson JR. Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. Circulation. 1991;83:778–86
  41. Osada N, Chaitman BR, Miller LW, et al. Cardiopulmonary exercise testing identifies low risk patients with heart failure and severely impaired exercise capacity considered for heart transplantation. J Am Coll Cardiol. 1998;31:577–82
  42. Davies LC, Wensel R, Georgiadou P, et al. Enhanced prognostic value from cardiopulmonary exercise testing in chronic heart failure by non-linear analysis: oxygen uptake efficiency slope. Eur Heart J. 2006;27:684–90
  43. Corra U, Giordano A, Bosimini E, et al. Oscillatory ventilation during exercise in patients with chronic heart failure: clinical correlates and prognostic implications. Chest. 2002;121:1572–80
  44. Corra U, Mezzani A, Bosimini E, Scapellato F, Imparato A, Giannuzzi P. Ventilatory response to exercise improves risk stratification in patients with chronic heart failure and intermediate functional capacity. Am Heart J. 2002;143:418–26
  45. Marburger CT, Brubaker PH, Pollock WE, Morgan TM, Kitzman DW. Reproducibility of cardiopulmonary exercise testing in elderly patients with congestive heart failure. Am J Cardiol. 1998;82:905–9
  46. Cicoira M, Davos CH, Florea V, et al. Chronic heart failure in the very elderly: clinical status, survival, and prognostic factors in 188 patients more than 70 years old. Am Heart J. 2001;142:174–80
  47. Mejhert M, Linder-Klingsell E, Edner M, Kahan T, Persson H. Ventilatory variables are strong prognostic markers in elderly patients with heart failure. Heart. 2002;88:239–43
  48. Davies LC, Francis DP, Piepoli M, Scott AC, Ponikowski P, Coats AJ. Chronic heart failure in the elderly: value of cardiopulmonary exercise testing in risk stratification. Heart. 2000;83:147–51
  49. Scardovi AB, Coletta C, De Maria R, et al. The cardiopulmonary exercise test is safe and reliable in elderly patients with chronic heart failure. J Cardiovasc Med (Hagerstown). 2007;8:608–612
  50. Brubaker PH, Marburger CT, Morgan TM, Fray B, Kitzman DW. Exercise responses of elderly patients with diastolic versus systolic heart failure. Med Sci Sports Exerc. 2003;35:1477–85
  51. Moore B, Brubaker PH, Stewart KP, Kitzman DW. VE/VCO2 slope in older heart failure patients with normal versus reduced ejection fraction compared with age-matched healthy controls. J Card Fail. 2007;13:259–62
  52. Kitzman DW, Little WC, Brubaker PH, et al. Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure. Jama. 2002;288:2144–50

PII: S0167-5273(07)01619-1

doi: 10.1016/j.ijcard.2007.10.004

International Journal of Cardiology
Volume 125, Issue 2 , Pages 166-171 , 10 April 2008