International Journal of Cardiology
Volume 129, Issue 3 , Pages 333-338 , 13 October 2008

Aerosolized iloprost for postoperative pulmonary hypertensive crisis in children with congenital heart disease

  • Alisa Limsuwan

      Affiliations

    • Division of Pediatric Cardiology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    • Corresponding Author InformationCorresponding author. Division of Pediatric Cardiology, Ramathibodi Hospital, Rama VI Road, Bangkok 10400, Thailand. Tel.: +662 201 1685; fax: +662 201 1850.
  • ,
  • Suthep Wanitkul

      Affiliations

    • Division of Pediatric Cardiology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • ,
  • Anant Khosithset

      Affiliations

    • Division of Pediatric Cardiology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • ,
  • Sukasom Attanavanich

      Affiliations

    • Division of Cardiothoracic Surgery, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • ,
  • Piya Samankatiwat

      Affiliations

    • Division of Cardiothoracic Surgery, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Received 20 December 2006 ,Revised 11 May 2007 ,Accepted 3 August 2007.

References 

  1. Brown KL, Ridout DA, Goldman AP, Hoskote A, Penny DJ. Risk factors for long intensive care unit stay after cardiopulmonary bypass in children. Crit Care Med. 2003;31(1):28–33
  2. Hopkins RA, Bull C, Haworth SG, de Leval MR, Stark J. Pulmonary hypertensive crises following surgery for congenital heart defects in young children. Eur J Cardio-Thorac Surg. 1991;5(12):628–634
  3. Bando K, Turrentine MW, Sharp TG, et al. Pulmonary hypertension after operations for congenital heart disease: analysis of risk factors and management. J Thorac Cardiovasc Surg. 1996;112(6):1600–1607[discussion 1607-9]
  4. Schranz D, Huth R, Wippermann CF, Ritzerfeld S, Schmitt FX, Oelert H. Nitric oxide and prostacyclin lower suprasystemic pulmonary hypertension after cardiopulmonary bypass. Eur J Pediatr. 1993;152(10):793–796
  5. Snow DJ, Gray SJ, Ghosh S, et al. Inhaled nitric oxide in patients with normal and increased pulmonary vascular resistance after cardiac surgery. Br J Anaesth. 1994;72(2):185–189
  6. Journois D, Pouard P, Mauriat P, Malhere T, Vouhe P, Safran D. Inhaled nitric oxide as a therapy for pulmonary hypertension after operations for congenital heart defects. J Thorac Cardiovasc Surg. 1994;107(4):1129–1135
  7. Miller OI, Celermajer DS, Deanfield JE, Macrae DJ. Very-low-dose inhaled nitric oxide: a selective pulmonary vasodilator after operations for congenital heart disease. J Thorac Cardiovasc Surg. 1994;108(3):487–494
  8. Beghetti M, Habre W, Friedli B, Berner M. Continuous low dose inhaled nitric oxide for treatment of severe pulmonary hypertension after cardiac surgery in paediatric patients. Br Heart J. 1995;73(1):65–68
  9. Curran RD, Mavroudis C, Backer CL, Sautel M, Zales VR, Wessel DL. Inhaled nitric oxide for children with congenital heart disease and pulmonary hypertension. Ann Thorac Surg. 1995;60(6):1765–1771
  10. Goldman AP, Delius RE, Deanfield JE, de Leval MR, Sigston PE, Macrae DJ. Nitric oxide might reduce the need for extracorporeal support in children with critical postoperative pulmonary hypertension. Ann Thorac Surg. 1996;62(3):750–755
  11. Russell IA, Zwass MS, Fineman JR, et al. The effects of inhaled nitric oxide on postoperative pulmonary hypertension in infants and children undergoing surgical repair of congenital heart disease. Anesth Analg. 1998;87(1):46–51
  12. Day RW, Hawkins JA, McGough EC, Crezee KL, Orsmond GS. Randomized controlled study of inhaled nitric oxide after operation for congenital heart disease. Ann Thorac Surg. 2000;69(6):1907–1912
  13. Miller OI, Tang SF, Keech A, Pigott NB, Beller E, Celermajer DS. Inhaled nitric oxide and prevention of pulmonary hypertension after congenital heart surgery: a randomised double-blind study. Lancet. 2000;356(9240):1464–1469
  14. Morris K, Beghetti M, Petros A, Adatia I, Bohn D. Comparison of hyperventilation and inhaled nitric oxide for pulmonary hypertension after repair of congenital heart disease. Crit Care Med. 2000;28(8):2974–2978
  15. Bizzarro M, Gross I. Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with congenital heart disease. Cochrane Database Syst Rev. 2005;(4):CD005055
  16. Carroll CL, Backer CL, Mavroudis C, Cook K, Goodman DM. Inhaled prostacyclin following surgical repair of congenital heart disease—a pilot study. J Card Surg. 2005;20(5):436–439
  17. Chen YF, Oparil S. Endothelial dysfunction in the pulmonary vascular bed. Am J Med Sci. 2000;320(4):223–232
  18. Rimensberger PC, Spahr-Schopfer I, Berner M, et al. Inhaled nitric oxide versus aerosolized iloprost in secondary pulmonary hypertension in children with congenital heart disease: vasodilator capacity and cellular mechanisms. Circulation. 2001;103(4):544–548
  19. Theodoraki K, Rellia P, Thanopoulos A, et al. Inhaled iloprost controls pulmonary hypertension after cardiopulmonary bypass. Can J Anaesth. 2002;49(9):963–967
  20. Rex S, Busch T, Vettelschoss M, de Rossi L, Rossaint R, Buhre W. Intraoperative management of severe pulmonary hypertension during cardiac surgery with inhaled iloprost. Anesthesiology. 2003;99(3):745–747
  21. Muller M, Scholz S, Kwapisz M, Akinturk H, Thul J, Hempelmann G. Use of inhaled iloprost in a case of pulmonary hypertension during pediatric congenital heart surgery. Anesthesiology. 2003;99(3):743–744
  22. Celermajer DS, Cullen S, Deanfield JE. Impairment of endothelium-dependent pulmonary artery relaxation in children with congenital heart disease and abnormal pulmonary hemodynamics. Circulation. 1993;87(2):440–446
  23. Wessel DL, Adatia I, Giglia TM, Thompson JE, Kulik TJ. Use of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass. Circulation. 1993;88(5 Pt 1):2128–2138
  24. Journois D, Baufreton C, Mauriat P, Pouard P, Vouhe P, Safran D. Effects of inhaled nitric oxide administration on early postoperative mortality in patients operated for correction of atrioventricular canal defects. Chest. 2005;128(5):3537–3544

PII: S0167-5273(07)01798-6

doi: 10.1016/j.ijcard.2007.08.084

International Journal of Cardiology
Volume 129, Issue 3 , Pages 333-338 , 13 October 2008