International Journal of Cardiology
Volume 135, Issue 3 , Pages 393-396 , 10 July 2009

Beta blockers for the prevention of atrial fibrillation after coronary artery bypass surgery: Carvedilol versus metoprolol

  • Turgay Celik

      Affiliations

    • Gulhane Military Medical Academy, School of Medicine, Department of Cardiology, 06018 Etlik, Ankara, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +90 312 3044268; fax: +90 312 3044250.
    • ,
  • Atila Iyisoy

      Affiliations

    • Gulhane Military Medical Academy, School of Medicine, Department of Cardiology, 06018 Etlik, Ankara, Turkey
    • ,
  • Bekim Jata

      Affiliations

    • Gulhane Military Medical Academy, School of Medicine, Department of Cardiology, 06018 Etlik, Ankara, Turkey
    • ,
  • Murat Celik

      Affiliations

    • Gulhane Military Medical Academy, School of Medicine, Department of Cardiology, 06018 Etlik, Ankara, Turkey
    • ,
  • Celalettin Gunay

      Affiliations

    • Gulhane Military Medical Academy, Department of Cardiothoracic Surgery, Etlik, Ankara, Turkey
    • ,
  • Ersoy Isik

      Affiliations

    • Gulhane Military Medical Academy, School of Medicine, Department of Cardiology, 06018 Etlik, Ankara, Turkey

Received 18 September 2007 ,Accepted 11 December 2007.

References 

  1. Acikel S, Bozbas H, Gultekin B, et al. Comparison of the efficacy of metoprolol and carvedilol for preventing atrial fibrillation after coronary bypass surgery. Int J Cardiol. May 11 2007;[Electronic publication ahead of print]
  2. Maisel WH, Rawn JD, Stevenson WG. Atrial fibrillation after cardiac surgery. Ann Intern Med. 2001;135:1061–1073
  3. Mathew JP, Fontes ML, Tudor IC, et al. A multicenter risk index for atrial fibrillation after cardiac surgery. JAMA. 2004;291:1720–1729
  4. Villareal RP, Hariharan R, Liu BC, et al. Postoperative atrial fibrillation and mortality after coronary artery bypass surgery. J Am Coll Cardiol. 2004;43:742–748
  5. Creswell LL, Schuessler RB, Rosenbloom M, Cox JL. Hazards of postoperative trial arrhythmias. Ann Thorac Surg. 1993;56:539–549
  6. Bharucha DB, Marinchak RA. Arrhythmias after cardiac surgery: atrial fibrillation and atrial flutter. In:  Rose BD editors. UpToDate. Wellesley: UpToDate; 2006;
  7. Cox JL. A perspective of postoperative atrial fibrillation in cardiac operations. Ann Thorac Surg. 1993;56:405–409
  8. Tsikouris JP, Kluger J, Song J, White CM. Changes in P-wave dispersion and P-wave duration after open heart surgery are associated with the peak incidence of atrial fibrillation. Heart Lung. 2001;30:466–471
  9. Dupont E, Ko YS, Rothery S, et al. The gap-junctional protein connexin40 is elevated in patients susceptible to postoperative atrial fibrillation. Circulation. 2001;103:842–849
  10. Korantzopoulos P, Kolettis TM, Galaris D, Goudevenos JA. The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation. Int J Cardiol. Feb 7 2007;115:135–143
  11. Lahtinen J, Biancari F, Salmela E, et al. Postoperative atrial fibrillation is a major cause of stroke after on-pump coronary artery bypass surgery. Ann Thorac Surg. 2004;77:1241–1244
  12. Hogue CW, Murphy SF, Schechtman KB, Davila-Roman VG. Risk factors for early or delayed stroke after cardiac surgery. Circulation. 1999;100:642–647
  13. Crystal E, Garfinkle MS, Connolly SS, Ginger TT, Sleik K, Yusuf SS. Interventions for preventing post-operative atrial fibrillation in patients undergoing heart surgery. Cochrane Database Syst Rev. 2004;CD003611:
  14. Quader MA, McCarthy PM, Gillinov AM, et al. Does preoperative atrial fibrillation reduce survival after coronary artery bypass grafting?. Ann Thorac Surg. 2004;77:1514–1522
  15. Jones RH. The year in cardiovascular surgery. J Am Coll Cardiol. 2005;45:1517–1528
  16. Crystal E, Connolly SJ, Sleik K, Ginger TJ, Yusuf S. Interventions on prevention of postoperative atrial fibrillation in patients undergoing heart surgery: a meta-analysis. Circulation. 2002;106:75–80
  17. Eagle KA, Guyton RA, Davidoff R, et al. ACC/AHA 2004 guideline update for coronary artery bypass graft surgery: summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1999 Guidelines for Coronary Artery Bypass Graft Surgery). J Am Coll Cardiol. 2004;44:e213–e310
  18. Kamei M, Morita S, Hayashi Y, Kanmura Y, Kuro M. Carvedilol versus Metoprolol for the prevention of atrial fibrillation after off-pump coronary bypass surgery: rationale and design of the Carvedilol or Metoprolol Post-Revascularization Atrial Fibrillation Controlled Trial (COMPACT). Cardiovasc Drugs Ther. 2006;20:219–227
  19. El-Sherif N, Turitto G. Electrophysiologic effects of carvedilol: is carvedilol an antiarrhythmic agent?. Pacing Clin Electrophysiol. 2005;28:985–990
  20. Gheorghiade M, Robbins JD, Lukas MA. Role of carvedilol in atrial fibrillation: insights from clinical trials. Am J Cardiol. 2004;93:53B–57B[suppl]
  21. Katritsis DG, Panagiotakos DB, Karvouni E, et al. Comparison of effectiveness of carvedilol versus bisoprolol for maintenance of sinus rhythm after cardioversion of persistent atrial fibrillation. Am J Cardiol. 2003;92:1116–1119
  22. Merritt JC, Niebauer M, Tarakji K, Hammer D, Mills RM. Comparison of effectiveness of carvedilol versus metoprolol or atenolol for atrial fibrillation appearing after coronary artery bypass grafting or cardiac valve operation. Am J Cardiol. 2003;92:735–736
  23. El-Sherif N, Turitto G. Electrophysiologic effects of carvedilol: is carvedilol an antiarrhythmic agent?. Pacing Clin Electrophysiol. 2005;28:985–990

PII: S0167-5273(08)00008-9

doi: 10.1016/j.ijcard.2007.12.026

International Journal of Cardiology
Volume 135, Issue 3 , Pages 393-396 , 10 July 2009

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