International Journal of Cardiology
Volume 134, Issue 1 , Pages 52-58 , 1 May 2009

Long-term association of brachial artery flow-mediated vasodilation and cardiovascular events in middle-aged subjects with no apparent heart disease

  • Michael Shechter

      Affiliations

    • Heart Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Israel
    • Corresponding Author InformationCorresponding author. Heart Institute, Chaim Sheba Medical Center, 52621 Tel Hashomer, Israel. Tel.: +11 972 3 5302645; fax: +11 972 3 6780581.
  • ,
  • Assaf Issachar

      Affiliations

    • Heart Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Israel
  • ,
  • Ibrahim Marai

      Affiliations

    • Heart Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Israel
  • ,
  • Nira Koren-Morag

      Affiliations

    • Heart Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Israel
  • ,
  • Dov Freinark

      Affiliations

    • Heart Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Israel
  • ,
  • Yael Shahar

      Affiliations

    • Heart Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Israel
  • ,
  • Alon Shechter

      Affiliations

    • Heart Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Israel
  • ,
  • Micha S. Feinberg

      Affiliations

    • Heart Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Israel

Received 31 July 2007 ,Revised 20 December 2007 ,Accepted 11 January 2008.

References 

  1. Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arteriosc Thromb Vasc Biol. 2003;23:168–175
  2. Corretti MC, Anderson TJ, Benjamin EJ, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilatation of the brachial artery. J Am Coll Cardiol. 2002;39:257–265
  3. Vogel RA. Coronary risk factors, endothelial function, and atherosclerosis: a review. Clin Cardiol. 1997;20:426–432
  4. McLenachan JM, Williams JK, Fish RD, et al. Loss of flow-mediated endothelium-dependent dilation occurs early in the development of atherosclerosis. Circulation. 1991;84:1272–1277
  5. Rizzoni D. Endothelial function in hypertension: fact or fantasy?. J Hypertens. 2002;20:1479–1481
  6. Drexler H, Hayoz D, Münzel T, et al. Endothelial function in chronic congestive heart failure. Am J Cardiol. 1992;69:1596–1601
  7. Wildansky ME, Gokce N, Keaney JF, et al. The clinical implication of endothelial dysfunction. J Am Coll Cardiol. 2003;42:1149–1160
  8. Lerman A, Zeiher AM. Endothelial function cardiac events. Circulation. 2005;111:363–368
  9. Shechter M, Sharir M, Labrador MJ, et al. Oral magnesium therapy improves endothelial function in patients with coronary artery disease. Circulation. 2000;102:2353–2358
  10. Shechter M, Matetzky S, Feinberg MS, et al. External counterpulsation therapy improves endothelial function in patients with refractory angina pectoris. J Am Coll Cardiol. 2003;42:2090–2095
  11. Shechter M, Sharir M, Paul Labrador M, et al. Improvement in endothelium-dependent brachial artery flow-mediated vasodilation with low-density lipoprotein cholesterol levels below 100 mg/dl. Am J Cardiol. 2000;86:1256–1259
  12. Freimark D, Feinberg M, Matetzky S, Shechter M. The impact of intermittent intravenous dobutamine therapy on endothelial function in patients with severe chronic heart failure. Am Heart J. 2004;148:878–882
  13. Shechter M, Beigel R, Freimark D, et al. Short-term sibutramine therapy is associated with weight loss and improved endothelial function in obese patients with coronary artery disease. Am J Cardiol. 2006;97:1650–1653
  14. Arbel Y, Dvir D, Feinberg MS, et al. The association between right coronary artery morphology and vascular endothelial function. Int J Cardiol. 2007;115:19–23
  15. Brevetti G, Silvestro A, Schiano V, et al. Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease. Circulation. 2003;108:2093–2098
  16. Fichtlscherer S, Breuer S, Zeiher AM. Prognostic value of systemic endothelial dysfunction in patients with acute coronary syndromes. Circulation. 2004;110:1926–1932
  17. Heitzer T, Schlinzig T, Krohn K, et al. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation. 2001;104:2673–2678
  18. Gokce N, Keaney JF, Hunter LM, et al. Predictive value of non-invasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. J Am Coll Cardiol. 2003;41:1769–1775
  19. Gokce N, Keaney JF, Hunter LM, et al. Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function. Circulation. 2002;105:1567–1572
  20. Suwaidi JA, Hamasaki S, Higano ST, et al. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation. 2000;101:948–954
  21. Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation. 2000;101:1899–1906
  22. Halcox JP, Schenke WH, Zalos G, et al. Prognostic value of coronary vascular endothelial dysfunction. Circulation. 2002;106:653–658
  23. Bugiardini R, Manfrini O, Pizzi C, et al. Endothelial function predicts future development of coronary artery disease. Circulation. 2004;109:2518–2523
  24. Perticone F, Ceravolo R, Pujia A, et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation. 2001;104:191–196
  25. Neunteufl T, Heher S, Katzenschlager R, et al. Late prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain. Am J Cardiol. 2000;86:207–210
  26. Yeboah J, Crouse J, Hsu FC, et al. Brachial flow-mediated dilation predicts incident cardiovascular events in older adults. The Cardiovascular Health Study. Circulation. 2007;115:2390–2397
  27. Anderson T. Prognostic significance of brachial flow-mediated vasodilation. Circulation. 2007;115:2373–2375
  28. Vita JA, Keaney JF. Endothelial function: a barometer for cardiovascular risk?. Circulation. 2002;106:640–642
  29. Vogel RA, Corretti MC, Plotnick GD. A comparison of the assessment of flow-mediated brachial artery vasodilation using upper versus lower arm arterial occlusion in subjects with and without coronary risk factors. Clin Cardiol. 2000;23:571–575
  30. Agewall S, Doughty RN, Bagg W, et al. Comparison of ultrasound assessment of flow-mediated dilatation in the radial and brachial artery with upper and forearm cuff position. Clin Physiol. 2001;21:9–14
  31. Berry KL, Skyrme-Jones AP, Meredith IT. Occlusion cuff position is an important determinant of the time course and magnitude of human brachial artery flow-mediated dilation. Clin Sci. 2000;99:261–267

 Part of this study was presented as an abstract at the 55th Annual Scientific Session of the American College of Cardiology, Atlanta, Georgia, USA, March 2006.

PII: S0167-5273(08)00311-2

doi: 10.1016/j.ijcard.2008.01.021

International Journal of Cardiology
Volume 134, Issue 1 , Pages 52-58 , 1 May 2009