International Journal of Cardiology
Volume 135, Issue 3 , Page 398, 10 July 2009

In response to article entitled “Coronary spasm and hypersensitivity to amoxicillin: Kounis or not Kounis syndrome?”

Gazi University Faculty of Medicine, Department of Cardiology, Besevler, 06500 Ankara, Turkey

Received 31 December 2007; accepted 5 April 2008. published online 16 June 2008.

Abstract 

The concurrence of acute coronary syndrome with amoxicillin/clavulanic acid intake has been defined as Kounis syndrome. There are some controversial factors which may effect this circumstance. Particularly, the condition which triggers the coronary vasospasm may mimic this syndrome. Furthermore, in the present case, an allergic study had been performed, showing hypersensitivity to penicillin and beta-lactamic agents that ruled out the role of amoxicillin administration.

Keywords: Kounis syndrome, Amoxicillin

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PII: S0167-5273(08)00396-3

doi:10.1016/j.ijcard.2008.04.001

International Journal of Cardiology
Volume 135, Issue 3 , Page 398, 10 July 2009