International Journal of Cardiology
Volume 135, Issue 2 , Pages 245-248 , 26 June 2009

HVJ-AVE liposome-mediated Tissue Factor Pathway Inhibitor (TFPI) gene transfer with recombinant TFPI (rTFPI) irrigation attenuates restenosis in atherosclerotic arteries

  • Xinhua Yin

      Affiliations

    • Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin150086, Heilongjiang, China
    • Corresponding Author InformationCorresponding author. Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, No. 194, XueFu Road, NanGang District, Harbin150086, Heilongjiang Province, China. Tel.: +86 451 89907700, +86 13199561899; fax: +86 451 86620586.
    • ,
  • Yu Fu

      Affiliations

    • Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin150086, Heilongjiang, China
    • ,
  • Chikao Yutani

      Affiliations

    • Department of Pathology, National Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita City, Osaka 565-8565, Japan
    • ,
  • Yoshihiko Ikeda

      Affiliations

    • Department of Pathology, National Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita City, Osaka 565-8565, Japan
    • ,
  • Keiichi Enjyoji

      Affiliations

    • Department of Etiology and Pathogenesis, National Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita City, Osaka 565-8565, Japan
    • ,
  • Hisao Kato

      Affiliations

    • Department of Etiology and Pathogenesis, National Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita City, Osaka 565-8565, Japan

Received 6 December 2007 ,Accepted 9 February 2008.

References 

  1. Taubman MB, Fallon JT, Schecter AD, et al. Tissue factor in the pathogenesis of atherosclerosis. Thromb Haemost. 1997;78(1):200–204
  2. Marmur JD, Rossikhina M, Guha A, et al. Tissue factor is rapidly induced in arterial smooth muscle after balloon injury. J Clin Invest. 1993;91(5):2253–2259
  3. Koop C, Holzenbein T, Steiner S, et al. Inhibition of restenosis by tissue factor pathway inhibitor: in vivo and in vitro evidence for suppressed monocyte chemoattraction and reduced gelatinolytic activity. Blood. 2004;103(5):1653–1661
  4. Brown DM, Kania NM, Chol ET, et al. Local irrigation with tissue factor pathway inhibitor inhibits intimal hyperplasia induced by arterial interventions. Arch Surg. 1996;131:1086–1090
  5. Yin X, Yutani C, Ikeda Y, et al. Tissue factor pathway inhibitor gene delivery Using HVJ-AVE liposomes markedly reduces restenosis in atherosclerotic arteries. Cardiovasc Res. 2002;56(3):454–463
  6. Atsuchi N, Nishida T, Marutsuka K, et al. Combination of a brief irrigation with tissue factor pathway inhibitor (TFPI) and adenovirus-mediated local TFPI gene transfer additively reduces neointima formation in balloon-injured rabbit carotid arteries. Circulation. 2001;103(4):570–575
  7. Kim SW, Mintz GS, Escolar E, et al. An intravascular ultrasound analysis of the mechanisms of restenosis comparing drug-eluting stents with brachytherapy. Am J Cardiol. 2006;97(9):1292–1298
  8. Lwaleed BA, Bass P. Tissue factor pathway inhibitor: structure, biology and involvement in disease. J Pathol. 2006;208:327–339
  9. Kato Hisao. Regulation of functions of vascular wall cells by tissue pathway inhibitor. Arterioscler Thromb Vasc Biol. 2002;22:539–548

PII: S0167-5273(08)00439-7

doi: 10.1016/j.ijcard.2008.02.009

International Journal of Cardiology
Volume 135, Issue 2 , Pages 245-248 , 26 June 2009

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