International Journal of Cardiology
Volume 135, Issue 2 , Pages 211-217 , 26 June 2009

Independent prediction of metabolic syndrome by plasma fibrinogen in men, and predictors of elevated levels

  • Altan Onat

      Affiliations

    • Turkish Society of Cardiology, Istanbul University, Turkey
    • Cerrahpaşa Medical Faculty, Istanbul University, Turkey
    • Corresponding Author InformationCorresponding author. Nisbetiye cad. 37/24, Etiler 34335, Istanbul, Turkey. Tel.: +90 212 351 6217; fax: +90 212 351 4235.
    • ,
  • Hakan Özhan

      Affiliations

    • Cardiology Department of Duzce U. Düzce Medical Faculty, Düzce, Turkey
    • ,
  • Enver Erbilen

      Affiliations

    • Cardiology Department of Duzce U. Düzce Medical Faculty, Düzce, Turkey
    • ,
  • Sinan Albayrak

      Affiliations

    • Cardiology Department of Duzce U. Düzce Medical Faculty, Düzce, Turkey
    • ,
  • Zekeriya Küçükdurmaz

      Affiliations

    • Cardiology Department of Gaziantep University Medical Faculty, Gaziantep, Turkey
    • ,
  • Günay Can

      Affiliations

    • Cerrahpaşa Medical Faculty, Istanbul University, Turkey
    • ,
  • İbrahim Keleş

      Affiliations

    • Cerrahpaşa Medical Faculty, Istanbul University, Turkey
    • ,
  • Gülay Hergenç

      Affiliations

    • Biology Department, Yildiz Technical University, Istanbul, Turkey

Received 30 November 2007 ,Revised 7 March 2008 ,Accepted 29 March 2008.

References 

  1. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999;340:448–454
  2. Tybjaerg-Hansen A, Agerholm-Larsen B, Humphries SE, Abildgaard S, Schnohr P, Nordestgaard BG. A common mutation (G−455-A) in the β-fibrinogen promoter is an independent predictor of plasma fibrinogen, but not of ischemic heart disease: a study of 9127 individuals based on the Copenhagen City Heart Study. J Clin Invest. 1997;99:3034–3039
  3. Krobot K, Hense HW, Cremer P, Eberle E, Keil U. Determinants of plasma fibrinogen: relation to body weight, waist-to-hip ratio, smoking, alcohol, age, and sex. Results from the second MONICA Augsburg survey 1989–1990. Arterioscler Thromb. 1992;12:780–788
  4. Bo M, Respo S, Morra F, Cassader M, Isaia G, Poli L. Body fat is the main predictor of fibrinogen levels in healthy non-obese men. Metabolism. 2004;53:984–988
  5. Duncan BB, Schmidt MI, Chambless LE, Folsom AR, Carpenter M, Heiss G. Fibrinogen, other putative markers of inflammation, and weight gain in middle-aged adults—the ARIC study: atherosclerosis risk in communities. Obes Res. 2000;8:279–286
  6. Fibrinogen Studies Collaboration. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA. 2005;294:1799–1809
  7. The ECAT Angina Pectoris Study Group Juhan-Vague I, Thompson SG, Jespersen J. Involvement of the hemostatic system in the insulin resistance syndrome: a study of 1500 patients with angina pectoris. Arterioscler Thromb. 1993;13:1865–1873
  8. Eliasson M, Evrin PE, Lunblad D. Fibrinogen and fibrinolytic variables in relation to anthropometry, lipids and blood pressure: the Northern Sweden MONICA Study. J Clin Epidemiol. 1994;47:513–524
  9. Imperatore G, Riccardi G, Iovine C, Rivellese AA, Vaccaro O. Plasma fibrinogen: a new factor of the metabolic syndrome. Diabetes Care. 1998;21:649–654
  10. Raynaud E, Perez-Martin A, Brun J, Aissa-Benhaddad A, Fedou C, Mercier J. Relationships between fibrinogen and insulin resistance. Atherosclerosis. 2000;150:365–370
  11. Onat A, Ceyhan K, Başar Ö, Erer B, Toprak S, Sansoy V. Metabolic syndrome: major impact on coronary risk in a population with low cholesterol levels — a prospective and cross-sectional evaluation. Atherosclerosis. 2002;165:285–292
  12. Onat A, Avci GS, Şenocak M, Örnek E, Gözükara Y. Plasma lipids and their interrelation in Turkish adults. J Epidem Commun Health. 1992;46:470–476
  13. von Clauss A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol. 1957;17:237–246
  14. Genuth S, Alberti KG, Bennett P, et al. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Follow-up report on the diagnosis of diabetes mellitus: the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2003;26:3160–3167
  15. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 2001;285:2486–2497
  16. Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004;109:433–438
  17. Onat A, Uyarel H, Hergenç G, Karabulut A, Albayrak S, Can G. Determinants and definition of abdominal obesity as related to risk of diabetes, metabolic syndrome and coronary disease in Turkish men: a prospective cohort study. Atherosclerosis. 2007;191:182–190
  18. Onat A, Sari I, Hergenc G, et al. Predictors of abdominal obesity and high susceptibility of cardiometabolic risk to its increments among Turkish women: a prospective population-based study. Metabolism. 2007;56:348–356
  19. The Fibrinogen Studies Collaboration. Regression dilution methods for meta-analysis: assessing long-term variability in plasma fibrinogen among 27,247 adults in 15 prospective studies. Int J Epidemiol. 2006;35:1570–1578
  20. Piché ME, Lemieux S, Weisnagel SJ, Corneau L, Nadeau A, Bergeron J. Relation of high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha, and fibrinogen to abdominal adipose tissue, blood pressure, and cholesterol and triglyceride levels in healthy postmenopausal women. Am J Cardiol. 2005;96:92–97
  21. Onat A, Can G, Hergenç G. Serum C-reactive protein is an independent risk factor predicting cardiometabolic risk. Metabolism. 2008;58:207–214
  22. Onat A, Ozhan H, Esen AM, et al. Prospective epidemiologic evidence of a “protective” effect of smoking on metabolic syndrome and diabetes among Turkish women — without associated overall health benefit. Atherosclerosis. 2007;193:380–389
  23. Shankar A, Wang JJ, Rochtchina E, Mitchell P. Positive association between plasma fibrinogen level and incident hypertension among men: population-based cohort study. Hypertension. 2006;48:1043–1049
  24. Nascetti S, Elosua R, Pena A, Covas MI, Senti M, Marrugat J. For the REGICOR Investigators. Variables associated with fibrinogen in a population-based study: interaction between smoking and age on fibrinogen concentration. Eur J Epidemiol. 2001;17:953–958
  25. Ford ES. The metabolic syndrome and C-reactive protein, fibrinogen, and leucocyte count: findings from the Third National Health and Nutrition Examination Survey. Atherosclerosis. 2003;168:351–358
  26. Wannamethee SG, Lowe GD, Shaper AG, Rumley A, Lennon L, Whincup PH. The metabolic syndrome and insulin resistance: relationship to haemostatic and inflammatory markers in older non-diabetic men. Atherosclerosis. 2005;181:101–108
  27. Mora S, Rifai N, Buring JE, Ridker PM. Additive value of immunoassay-measured fibrinogen and high-sensitivity C-reactive protein levels for predicting incident cardiovascular events. Circulation. 2006;114:381–387
  28. Onat A, Hergenç G, Karabulut A, Albayrak S, Can G, Kaya Z. Serum sex hormone-binding globulin, a determinant of cardiometabolic disorders independent of abdominal obesity and insulin resistance in elderly men and women. Metabolism. 2007;56:1356–1362
  29. Onat A, Hergenç G, Sarı I, Karabulut A, Can G. Elevated LDL-cholesterol level predicts diabetes in centrally obese women but not men: Relative roles of insulin resistance and central obesity. Circ J. 2007;71:1463–1467
  30. Rosenson RS, Mosca L, Staffileno BA, Tangney CC. Variability in fibrinogen measurements: an obstacle to cardiovascular risk stratification. Atherosclerosis. 2001;159:225–230

PII: S0167-5273(08)00522-6

doi: 10.1016/j.ijcard.2008.03.054

International Journal of Cardiology
Volume 135, Issue 2 , Pages 211-217 , 26 June 2009

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