International Journal of Cardiology
Volume 135, Issue 3 , Pages 308-314 , 10 July 2009

Heart rate turbulence in adults with repaired tetralogy of Fallot

  • Constantinos H. Davos

      Affiliations

    • Cardiovascular Research Laboratory, Biomedical Research Foundation, Academy of Athens, Greece
    • Adult Congenital Heart Program, Department of Cardiology, Royal Brompton Hospital, Sydney Street, London, UK
    • Corresponding Author InformationCorresponding author. 4 Soranou Ephessiou Street, 115 27 Athens, Greece. Tel.: +30 210 6597392, +30 210 6597405; fax: +30 210 6597405.
    • ,
  • Antonia C. Moutafi

      Affiliations

    • Cardiovascular Research Laboratory, Biomedical Research Foundation, Academy of Athens, Greece
    • ,
  • Anastasia Alexandridi

      Affiliations

    • Cardiovascular Research Laboratory, Biomedical Research Foundation, Academy of Athens, Greece
    • ,
  • Evdokia Petropoulou

      Affiliations

    • Cardiovascular Research Laboratory, Biomedical Research Foundation, Academy of Athens, Greece
    • ,
  • Emily Varela

      Affiliations

    • Cardiovascular Research Laboratory, Biomedical Research Foundation, Academy of Athens, Greece
    • ,
  • Aikaterini C. Chamakou

      Affiliations

    • Cardiovascular Research Laboratory, Biomedical Research Foundation, Academy of Athens, Greece
    • ,
  • Darrel P. Francis

      Affiliations

    • National Heart and Lung Institute, Imperial College of Science and Medicine, London, UK
    • ,
  • Philippe J. Kilner

      Affiliations

    • Department of Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK
    • ,
  • Massimo F. Piepoli

      Affiliations

    • National Heart and Lung Institute, Imperial College of Science and Medicine, London, UK
    • ,
  • Michael A. Gatzoulis

      Affiliations

    • Adult Congenital Heart Program, Department of Cardiology, Royal Brompton Hospital, Sydney Street, London, UK
    • National Heart and Lung Institute, Imperial College of Science and Medicine, London, UK

Received 17 December 2007 ,Accepted 7 March 2008.

References 

  1. Murphy JG, Gersh BJ, Mair DD, FDuster V, McGoon MD, Ilstrup DM, et al. Long-term outcome in patients undergoing surgical repair of tetralogy of Fallot. N Engl J Med. 1993;329:593–599
  2. Nollert G, Fischlein T, Bouterwek S, Bohmer C, Klinner W, Reichart B. Long-term survival in patients with repair of tetralogy of Fallot: 36-year follow-up of 490 survivors of the first year after surgical repair. J Am Coll Cardiol. 1997;30:1374–1383
  3. Gatzoulis MA, Balaji S, Webber SA, Siu SC, Hokanson JS, Poile C, et al. Risk factors for arrhythmia and sudden cardiac death late after repair of tetralogy of Fallot: a multicentre study. Lancet. 2000;356:975–981
  4. Davos C, Davlouros P, Wensel R, Francis D, Davies C, Kilner P, et al. Global impairment of cardiac autonomic nervous activity late after repair of tetralogy of Fallot. Circulation. 2002;106(suppl I):I-69–I-75
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  10. Bolger AP, Sharma R, Li W, Leenarts M, Kalra PR, Kemp M, et al. Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease. Circulation. 2002;106:92–99
  11. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation. 1996;93:1043–1065
  12. Gatzoulis MA, Till JA, Somerville J, Redington AN. Mechanoelectrical interaction in tetralogy of Fallot. QRS prolongation relates to right ventricular size and predicts malignant ventricular arrhythmias and sudden death. Circulation. 1995;92:231–237
  13. Davlouros PA, Kilner PJ, Hornung TS, Li W, Francis JM, Moon JC, et al. Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction. J Am Coll Cardiol. 2002;40:2044–2052
  14. Barthel P, Schneider R, Bauer A, Ulm K, Schmitt C, Schomig A, et al. Risk stratification after acute myocardial infarction by heart rate turbulence. Circulation. 2003;108:1221–1226
  15. Sade E, Aytemir K, Oto A, Nazli N, Ozmen F, Ozkutlu H, et al. Assessment of heart rate turbulence in the acute phase of myocardial infarction for long-term prognosis. Pacing Clin Electrophysiol. 2003;26(2 Pt 1):544–550
  16. Jokinen V, Tapanainen J, Seppanen T, Huikuri H. Temporal changes and prognostic significance of measures of heart rate dynamics after acute myocardial infarction in the beta-blocking era. Am J Cardiol. 2003;92:907–912
  17. Ghuran A, Reid F, La Rovere MT, Schmidt G, Bigger JT, Camm AJ, et al. ATRAMI Investigators. Heart rate turbulence-based predictors of fatal and nonfatal cardiac arrest (The Autonomic Tone and Reflexes After Myocardial Infarction sub-study). Am J Cardiol. 2002;89:184–190
  18. Yalta K, Erdem A, Yilmaz A, Turgut OO, Yilmaz MB, Yontar C, et al. Heart rate turbulence: an additional parameter in determining the need for mechanical relief of mitral stenosis?. J Heart Valve Dis. 2007;16:255–259
  19. Grimm W, Schmidt G, Maisch B, Sharkova J, Müller HH, Christ M. Prognostic significance of heart rate turbulence following ventricular premature beats in patients with idiopathic dilated cardiomyopathy. J Cardiovasc Electrophysiol. 2003;14:819–824
  20. Lin LY, Lai LP, Lin JL, Du CC, Shau WY, Chan HL, et al. Tight mechanism correlation between heart rate turbulence and baroreflex sensitivity: sequential autonomic blockade analysis. J Cardiovasc Electrophysiol. 2002;13:427–431
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  22. Dimopoulos K, Okonko DO, Diller GP, Broberg CS, Salukhe TV, Babu-Narayan SV, et al. Abnormal ventilatory response to exercise in adults with congenital heart disease relates to cyanosis and predicts survival. Circulation. 2006;113:2796–2802
  23. Ponikowski P, Francis DP, Piepoli MF, Davies LC, Chua TP, Davos CH, et al. Enhanced ventilatory response to exercise in patients with chronic heart failure and preserved exercise tolerance: marker of abnormal cardiorespiratory reflex control and predictor of poor prognosis. Circulation. 2001;103:967–972

PII: S0167-5273(08)00532-9

doi: 10.1016/j.ijcard.2008.03.096

International Journal of Cardiology
Volume 135, Issue 3 , Pages 308-314 , 10 July 2009

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