International Journal of Cardiology
Volume 136, Issue 2 , Pages 178-185 , 14 August 2009

Intracoronary autologous bone marrow stem cells transfer for patients with acute myocardial infarction: A meta-analysis of randomised controlled trials

  • Shu-ning Zhang

      Affiliations

    • Shu-ning Zhang and Ai-jun Sun contributed equally to this work.
    • ,
  • Ai-jun Sun

      Affiliations

    • Shu-ning Zhang and Ai-jun Sun contributed equally to this work.
    • ,
  • Jun-bo Ge

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, 180 Fenglin Road, Shanghai 200032, China. Tel: +86 21 64041990x2745; fax: +86 21 64223006.
    • ,
  • Kang Yao
    • ,
  • Zhe-yong Huang
    • ,
  • Ke-qiang Wang
    • ,
  • Yun-zeng Zou

Received 28 December 2007 ,Revised 14 April 2008 ,Accepted 23 April 2008.

References 

  1. Strauer BE, Brehm M, Zeus T, et al. Repair of infracted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation. 2002;106(15):1913–1918
  2. Fernandez-Aviles F, San Roman JA, Garcıa-Frade J, et al. Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction. Circ Res. 2004;7(95):742–748
  3. Kuethe F, Richartz BM, Sayer HG, et al. Lack of regeneration of myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans with large anterior myocardial infarctions. Int J Cardiol. 2004;97(1):123–127
  4. Mansour S, Vanderheyden M, De Bruyne B, et al. Intracoronary delivery of hematopoietic bone marrow stem cells and luminal loss of the infarct-related artery in patients with recent myocardial infarction. J Am Coll Cardiol. 2006;47(8):1727–1730
  5. Vulliet PR, Greeley M, Halloran SM, MacDonald KA, Kittleson MD. Intra-coronary arterial injection of mesenchymal stromal cells and microinfarction in dogs. Lancet. 2004;363(9411):783–784
  6. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomised clinical trials: is blinding necessary?. Control Clin Trials. 1996;17(1):1–12
  7. Wollert KC, Meyer GP, Lotz J, et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet. 2004;364(9429):141–148
  8. Chen SL, Fang WW, Ye F, et al. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction.. Am J Cardiol. 2004;94(1):92–95
  9. Ge J, Li Y, Qian J, et al. Efficacy of emergent transcatheter transplantation of stem cells for treatment of acute myocardial infarction (TCT-STAMI). Heart. 2006;92(12):1764–1767
  10. Schachinger V, Erbs S, Elsasser A, et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Eng J Med. 2006;355(12):1210–1221
  11. Janssens S, Dubois C, Bogaert J, et al. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet. 2006;367(9505):113–122
  12. Lunde K, Solheim S, Aakhus S, et al. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med. 2006;355(12):1199–1209
  13. Cohn JN, Johnson GR, Shabetai R, et al. Mechanistic data from the VA Cooperative Studies: ejection fraction, peak exercise oxygen consumption, cardiothoracic ratio, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure. Circulation. 1993;87(Suppl 6):VI5–V6
  14. Caplice NM. The future of cell therapy for acute myocardial infarction. Nat Clin Pract Cardiovasc Med. 2006;3(Suppl 1):S129–S132
  15. Bauersachs J, Thum T, Frantz S, Ertl G. Cardiac regeneration by progenitor cells—bedside before bench?. Eur J Clin Invest. 2005;35(7):417–420
  16. Abdel-Latif A, Bolli R, Tleyjeh IM, et al. Adult bone marrow-derived cells for cardiac repair. Arch Intern Med. 2007;167(10):989–997
  17. Zhang S, Ge J, Sun A, et al. Comparison of various kinds of bone marrow stem cells for the repair of infarcted myocardium: Single clonally purified non-hematopoietic mesenchymal stem cells serve as a superior source. J Cell Biochem. 2006;99(4):1132–1147
  18. Jyotsna M, Vemuganti GK, Reddy P, Chandra KS. Autologous bone marrow-derived progenitor cell myocardial delivery for recent myocardial infarction patients following early angioplasty: results from a pilot study. Cardiovasc Revasc Med. 2006;7(4):217–221
  19. Schachinger V, Assmus B, Britten MB, et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI Trial. J Am Coll Cardiol. 2004;44(8):1690–1699
  20. Meyer GP, Wollert KC, Lotz J, et al. Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial. Circulation. 2006;113(10):1287–1294
  21. Frigerio M, Roubina E. Drugs for left ventricular remodeling in heart failure. Am J Cardiol. 2005;96(12A):10L–18L
  22. Kocher AA, Schuster MD, Szabolcs MJ, et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med. 2001;7(4):430–436
  23. Mangi AA, Noiseux N, Kong D, et al. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med. 2003;9(9):1195–1201
  24. Kawamoto A, Gwon HC, Iwaguro H, et al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation. 2001;103(5):634–637
  25. Schaefer A, Meyer GP, Fuchs M, et al. Impact of intracoronary bone marrow cell transfer on diastolic function in patients after acute myocardial infarction: results from the BOOST trial. Eur Heart J. 2006;27(8):929–935
  26. Fuchs S, Baffour R, Zhou YF, et al. Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia. J Am Coll Cardiol. 2001;37(6):1726–1732
  27. Zeng L, Hu Q, Wang X, et al. Bioenergetic and functional consequences of bone marrow-derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling. Circulation. 2007;115(14):1866–1875
  28. Thum T, Bauersachs J, Poole-Wilson PA, Volk HD, Anker SD. The dying stem cell hypothesis: immune modulation as a novel mechanism for progenitor cell therapy in cardiac muscle. J Am Coll Cardiol. 2005;46(10):1799–1802
  29. Kang HJ, Kim HS, Zhang SY, et al. Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. Lancet. 2004;363(9411):751–756
  30. Bartunek J, Vanderheyden M, Vandekerckhove B, et al. Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety. Circulation. 2005;112(Suppl 9):I178–183
  31. Schachinger V, Erbs S, Elsasser A, et al. Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial. Eur Heart J. 2006;27(23):2775–2783
  32. Prabhakara S, Heggunje W, Harjai Gregg KJ, et al. Procedural success versus clinical risk 1status in determining discharge of patients after primary angioplasty for acute myocardial infarction. J Am Coll Cardiol. 2004;44(7):1400–1407
  33. Marenzi G, Moltrasio M, Assanelli E, et al. Impact of cardiac and renal dysfunction on inhospital morbidity and mortality of patients with acute myocardial infarction undergoing primary angioplasty. Am Heart J. 2007;153(5):755–762

PII: S0167-5273(08)00626-8

doi: 10.1016/j.ijcard.2008.04.071

International Journal of Cardiology
Volume 136, Issue 2 , Pages 178-185 , 14 August 2009

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