International Journal of Cardiology
Volume 135, Issue 3 , Pages e83-e84 , 10 July 2009

Statins and prevention of atrial fibrillation in patients with heart failure

  • Tong Liu

      Affiliations

    • Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People's Republic of China
    • ,
  • Guangping Li

      Affiliations

    • Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People's Republic of China
    • Corresponding Author InformationCorresponding author. Tel.: +86 22 88328368; fax: +86 22 28261158.
    • ,
  • Panagiotis Korantzopoulos

      Affiliations

    • Department of Cardiology, University of Ioannina School of Medicine, 45001 Ioannina, Greece
    • ,
  • John A. Goudevenos

      Affiliations

    • Department of Cardiology, University of Ioannina School of Medicine, 45001 Ioannina, Greece

Received 3 January 2008 ,Accepted 24 April 2008.

References 

  1. Abi Nasr I, Mansencal N, Dubourg O. Management of atrial fibrillation in heart failure in the elderly. Int J Cardiol. 2008;125:178–182
  2. Hanna IR, Heeke B, Bush H, et al. Lipid-lowering drug use is associated with reduced prevalence of atrial fibrillation in patients with left ventricular systolic dysfunction. Heart Rhythm. 2006;3:881–886
  3. Dickinson MG, Hellkamp AS, Ip JH, et al. Statin therapy was associated with reduced atrial fibrillation and flutter in heart failure patients in SCD-HEFT. Heart Rhythm. 2006;3(Suppl):S49
  4. Adabag AS, Nelson DB, Bloomfield HE. Effects of statin therapy on preventing atrial fibrillation in coronary disease and heart failure. Am Heart J. 2007;154:1140–1145
  5. Kostapanos MS, Liberopoulos EN, Goudevenos JA, Mikhailidis DP, Elisaf MS. Do statins have an antiarrhythmic activity?. Cardiovasc Res. 2007;75:10–20
  6. Savelieva I, Camm J. Statins and polyunsaturated fatty acids for treatment of atrial fibrillation. Nat Clin Pract Cardiovasc Med. 2008;5:30–41
  7. Rosamond W, Flegal K, Friday G, et al. Heart disease and stroke statistics—2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2007;115:e69–e171
  8. Tousoulis D, Charakida M, Stefanadi E, Siasos G, Latsios G, Stefanadis C. Statins in heart failure. Beyond the lipid lowering effect. Int J Cardiol. 2007;115:144–150
  9. Shanes JG, Minadeo KN, Moret A, Groner M, Tabaie SA. Statin therapy in heart failure: prognostic effects and potential mechanisms. Am Heart J. 2007;154:617–623
  10. Liu T, Li L, Korantzopoulos P, Liu E, Li G. Statin use and development of atrial fibrillation: A systematic review and meta-analysis of randomized clinical trials and observational studies. Int J Cardiol. 2008;126:160–170
  11. Shiroshita-Takeshita A, Brundel BJ, Burstein B, et al. Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure. Cardiovasc Res. 2007;74:75–84
  12. Okazaki H, Minamino T, Wakeno M, et al. Statin prevents structural and electrical atrial remodeling in rat hypertensive heart failure induced by chronic inhibition of NO synthesis. Circulation. 2007;116(Suppl II):140
  13. Korantzopoulos P, Galaris D, Papaioannides D, Kokkoris S. C-reactive protein and oxidative stress in atrial fibrillation. Int J Cardiol. 2003;88:103–104
  14. Korantzopoulos P, Kolettis TM, Galaris D, Goudevenos JA. The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation. Int J Cardiol. 2007;115:135–143
  15. Liu T, Li G, Li L, Korantzopoulos P. Association between C-reactive protein and recurrence of atrial fibrillation after successful electrical cardioversion: a meta-analysis. J Am Coll Cardiol. 2007;49:1642–1648
  16. Korantzopoulos P, Galaris D, Papaioannides D, Siogas K. The possible role of oxidative stress in heart failure and the potential of antioxidant intervention. Med Sci Monit. 2003;9:RA120–RA125
  17. Liu T, Li GP, Huang TG. Anti-inflammatory therapies in atrial fibrillation. Int J Cardiol. 2005;104:359–360
  18. Musco S, Conway EL, Kowey PR. Drug therapy for atrial fibrillation. Med Clin North Am. 2008;92:121–141
  19. Korantzopoulos P, Kokkoris S. The antioxidant effects of statins may extend beyond atherosclerosis: potential benefits for atrial fibrillation and heart failure. Atherosclerosis. 2004;175:187
  20. Celik T, Iyisoy A, Dogru MT, Isik E. Statin use in chronic heart failure: waiting for the results of large prospective outcome trials. Int J Cardiol. 2009;132:122–124

PII: S0167-5273(08)00627-X

doi: 10.1016/j.ijcard.2008.04.042

International Journal of Cardiology
Volume 135, Issue 3 , Pages e83-e84 , 10 July 2009

Article Tools