International Journal of Cardiology
Volume 129, Issue 2 , Pages 187-192 , 26 September 2008

Effect of angiotensin receptor blockade on systemic right ventricular function and size: A small, randomized, placebo-controlled study

  • Judith Therrien

      Affiliations

    • MAUDE Unit, Jewish General Hospital and McGill University Health Center, McGill University, Montreal, Quebec, Canada
    • Corresponding Author InformationCorresponding author. Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine, Room E 206, Montreal, Quebec, Canada H3T 1E2. Tel.: +1 514 340 7540; fax: +1 514 340 7534.
  • ,
  • Yves Provost

      Affiliations

    • Congenital Cardiac Center for Adults, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
  • ,
  • Jeanine Harrison

      Affiliations

    • Congenital Cardiac Center for Adults, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
  • ,
  • Michael Connelly

      Affiliations

    • Calgary Adult Congenital Heart Peter Lougheed Center, Calgary, Canada
  • ,
  • Harald Kaemmerer

      Affiliations

    • Pediatric Cardiology and Congenital Heart Disease German Heart Center, Munich, Germany
  • ,
  • Garry D. Webb

      Affiliations

    • Philadelphia Adult Congenital Heart Center, University of Pennsylvania, USA

Received 10 March 2008 ,Accepted 25 April 2008.

References 

  1. Therrien J., Webb GD., Chapter 44. Adult congenital heart disease. Braunwald, 6th edition.
  2. Gelatt M, Hamilton R, McCrindle B, et al. Arrhythmia and mortality following the Mustard procedure: a thirty-year, single-center experience. J Am Coll Cardiol. 1997;29:194–201
  3. Millane T, Bernanrd EJ, Jaeggi E, et al. Role of ischemia and infarction in late right ventricular dysfunction after atrial repair of transposition of the great arteries. J Am Coll Cardiol. 2000;35:1661–1668
  4. Warnes CA, Somerville J. Transposition of the great arteries: late results in adolescents and adults after the Mustard procedure. Br Heart J. 1987;58:148–155
  5. Wilson NJ, Clarkson PM, Barratt-Boyes CHM, et al. Long-term outcome after the Mustard repair for simple transposition of the great arteries. J Am Coll Cardiol. 1998;32:758–765
  6. Puley G, Siu S, Connelly M, et al. Arrhythmia and survival in patients >18 years of age after the Mustard procedure for complete transposition of the great arteries. Am J Cardiol. 1999;83:1080–1084
  7. Gewillig M, Cullen S, Mertens B, Lesaffre E, Deanfield J. Risk factors for arrhythmia and death after Mustard operation for simple transposition of the great arteries. Circulation. 1991;84(suppl III):III187–III192
  8. Lubiszewska B, Gosiewska E, Hoffman P, et al. Myocardial perfusion and function of the systemic right ventricle in patients after atrial switch procedure for complete transposition: long-term follow-up. J Am Coll Cardiol. 2000;36:1365–1370
  9. Sharpe DN, Murphy J, Coxon R, Hannan SF. Enalapril in patients with chronic heart failure: a placebo-controlled, randomized, double-blind study. Circ. 1984;70:271–278
  10. Pfeffer MA, Lamas GA, Vaughan DE, Parisi AF, Braunwald E. Effect of captopril on progressive ventricular dilatation after anterior myocardial infarction. N Engl J Med. 1988;319:80–86
  11. Brilla CG, Funck RC, Rupp H. Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease. Circulation. 2000;102:1388–1393
  12. The CONSENSUS study group. Effects of enalapril on mortality in severe congestive heart failure. N Engl J Med. 1987;316:1429–1435
  13. The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med. 1991;325:293302
  14. The SAVE Investigators. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 1992;327:669–677
  15. Dore A, Houde C, Chan DL, et al. Angiotensin receptor blockade and exercise capacity in adults with systemic right ventricles: a multicenter, randomized, placebo controlled clinical trial. Circulation. 2005;112:2411–2416
  16. Hechter SJ, Fredriksen PM, Merchant N, et al. Angiotensin converting enzyme inhibitors in adults with the Mustard procedure. Am J Cardiol. 2001;87:660–663
  17. Lester SJ, McElhinney DB, Viloria E, et al. Effects of losartan in patients with a systemically functioning morphologic right ventricle after atrial repair of transposition of the great arteries. Am J Cardiol. 2001;88:1314–1316
  18. Jauhiainen T, Jarvinen VM, Hedali PE, Poutanen VP, Penttila A, Kupari M. MR gradient echo volumetric analysis of human cardiac cast: focus on the right ventricle. J Comput Assist Tomogr. 1998;22:899–903
  19. Heusch A, Koch JA, Krogmann ON, Korbmacher B, Bourgeois M. Volumetric analysis of the right and left ventricle in a porcine heart model: comparison of three-dimensional echocardiography, magnetic resonance imaging and angiocardiography. Eur J Ultrasound. 1999;9:245–255
  20. Boxt LM. Radiology of the right ventricle. Radiol Clin North Am. 1999;37:379–400
  21. Boxt LM. MR imaging of pulmonary hypertension and right ventricular dysfunction. Magn Reson Imaging Clin N Am. 1996;4:307–325
  22. Weber KT. Extracellular matrix remodeling in hart failure: a role for de novo angiotensin II generation. Circ. 1997;96:4065–4082
  23. Abdulla J, Barlera S, Latini R, et al. A systematic review: effect of angiotensin converting enzyme inhibition on left ventricular volumes and ejection fraction in patients with a myocardial infraction and in patients with left ventricular dysfunction. Eur J Heart Failure. 2007;9:129–135
  24. Piran S, Veldtman G, Siu S, Webb GD, Liu PP. Heart failure and ventricular dysfunction in patients with single or systemic right ventricles. Circulation. 2002;105:1189–1194
  25. Hornung TS, Kilner PJ, Vavlouros PA, Grothues F, Li W, Gatzoulis MA. Excessive right ventricular hypertrophic response in adults with the Mustard procedure for transposition of the great arteries. Am J Cardiol. 2002;90:800–803
  26. Babu-Narayan SV, Goktekin Om Moon JC, Broberg CS, et al. Late gadolinium enhancement cardiovascular magnetic resonance of the systemic right ventricle in adults with previous atrial redirection surgery for systemic right ventricle in adults with previous atrial redirection surgery for transposition of the great arteries. Circulation. 2005;111:2091–2098
  27. Zaffran S, Kelly RG, Meilhac SM, Buckingham ME, Brown NA. Right ventricular myocardium derives from the anterior heart field. Circ Res. 2004;95:261–268
  28. Fernandez Teran MA, Hurle JM. Myocardial fiber architecture of the human heart ventricles. Anat Rec. 1982;204:137–147
  29. Robinson B, Heise CT, Moore JW, et al. Afterload reduction therapy in patients following intraatrial baffle operation for transposition of the great arteries. Pediatr Cardiol. 2002;23:618–623
  30. Doughan ARK, McConnell ME, Book W. Effect of beta blockers (Carvedilol or Metoprolol XL) in patients with transposition of great arteries and dysfunction of the systemic right ventricle. Am J Cardiol. 2007;99:704–706
  31. Josephson CB, Howlett JG, Jackson SD, Finley J, Kells C. A case series of systemic right ventricular dysfunction post atrial switch for simple D-transposition of the great arteries: the impact of beta-blockade. Can J Cardiol. 2006;22:769–772

PII: S0167-5273(08)00639-6

doi: 10.1016/j.ijcard.2008.04.056

International Journal of Cardiology
Volume 129, Issue 2 , Pages 187-192 , 26 September 2008