International Journal of Cardiology
Volume 137, Issue 2 , Pages 116-122 , October 2009

Postoperative oral amiodarone versus oral bisoprolol as prophylaxis against atrial fibrillation after coronary artery bypass graft surgery: A prospective randomized trial

  • Ghassan Sleilaty

      Affiliations

    • Department of Cardiovascular Surgery, Hotel Dieu de France Hospital, Beirut, Lebanon
    • Corresponding Author InformationCorresponding author. Department of Cardiovascular Surgery, Hotel Dieu de France Hospital, Alfred Naccache Street, Achrafieh, Beirut, Lebanon. PB: 166830. Tel./fax: +961 1 42 61 81.
    • ,
  • Samia Madi-Jebara

      Affiliations

    • Department of Anesthesiology, Hotel Dieu de France Hospital, Beirut, Lebanon
    • ,
  • Alexandre Yazigi

      Affiliations

    • Department of Anesthesiology, Hotel Dieu de France Hospital, Beirut, Lebanon
    • ,
  • Fadia Haddad

      Affiliations

    • Department of Anesthesiology, Hotel Dieu de France Hospital, Beirut, Lebanon
    • ,
  • Gemma Hayeck

      Affiliations

    • Department of Anesthesiology, Hotel Dieu de France Hospital, Beirut, Lebanon
    • ,
  • Issam El Rassi

      Affiliations

    • Department of Cardiovascular Surgery, Hotel Dieu de France Hospital, Beirut, Lebanon
    • ,
  • Ramzi Ashoush

      Affiliations

    • Department of Cardiovascular Surgery, Hotel Dieu de France Hospital, Beirut, Lebanon
    • ,
  • Victor Jebara

      Affiliations

    • Department of Cardiovascular Surgery, Hotel Dieu de France Hospital, Beirut, Lebanon

Received 16 December 2007 ,Revised 6 June 2008 ,Accepted 28 June 2008.

References 

  1. Maisel WH, Rawn JD, Stevenson WG. Atrial fibrillation after cardiac surgery. Ann Intern Med. 2001;135:1061–1073
  2. Aasbo JD, Lawrence AT, Krishnan K, Kim MH, Trohman RG. Amiodarone prophylaxis reduces major cardiovascular morbidity and length of stay after cardiac surgery: a meta-analysis. Ann Intern Med. 2005;143:327–336
  3. Bradley D, Creswell LL, Hogue CW, Epstein AE, Prystowsky EN, Daoud EG. Pharmacologic prophylaxis: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery. Chest. 2005;128:39S–47S
  4. Fuster V, Ryden LE, Cannom DS, et al. ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing committee to revise the 2001 Guidelines for the management of patients with atrial fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation. 2006;114:e257–354
  5. Ommen SR, Odell JA, Stanton MS. Atrial arrhythmias after cardiothoracic surgery. N Engl J Med. 1997;336:1429–1434
  6. Mathew JP, Fontes ML, Tudor IC, et al. A multicenter risk index for atrial fibrillation after cardiac surgery. Jama. 2004;291:1720–1729
  7. Daoud EG, Strickberger SA, Man KC, et al. Preoperative amiodarone as prophylaxis against atrial fibrillation after heart surgery. N Engl J Med. 1997;337:1785–1791
  8. DiDomenico RJ, Massad MG. Pharmacologic strategies for prevention of atrial fibrillation after open heart surgery. Ann Thorac Surg. 2005;79:728–740
  9. Creswell LL, Schuessler RB, Rosenbloom M, Cox JL. Hazards of postoperative atrial arrhythmias. Ann Thorac Surg. 1993;56:539–549
  10. Crystal E, Connolly SJ, Sleik K, Ginger TJ, Yusuf S. Interventions on prevention of postoperative atrial fibrillation in patients undergoing heart surgery: a meta-analysis. Circulation. 2002;106:75–80
  11. Guarnieri T, Nolan S, Gottlieb SO, Dudek A, Lowry DR. Intravenous amiodarone for the prevention of atrial fibrillation after open heart surgery: the amiodarone reduction in coronary heart (ARCH) trial. J Am Coll Cardiol. 1999;34:343–347
  12. Mitchell LB, Exner DV, Wyse DG, et al. Prophylactic oral amiodarone for the prevention of arrhythmias that begin early after revascularization, valve replacement, or repair: PAPABEAR: a randomized controlled trial. Jama. 2005;294:3093–3100
  13. Andrews TC, Reimold SC, Berlin JA, Antman EM. Prevention of supraventricular arrhythmias after coronary artery bypass surgery. A meta-analysis of randomized control trials. Circulation. 1991;84:III236–III244
  14. Kowey PR, Taylor JE, Rials SJ, Marinchak RA. Meta-analysis of the effectiveness of prophylactic drug therapy in preventing supraventricular arrhythmia early after coronary artery bypass grafting. Am J Cardiol. 1992;69:963–965
  15. Wurdeman RL, Mooss AN, Mohiuddin SM, Lenz TL. Amiodarone vs sotalol as prophylaxis against atrial fibrillation/flutter after heart surgery⁎: a meta-analysis. Chest. 2002;121:1203–1210
  16. Zimmer J, Pezzullo J, Choucair W, et al. Meta-analysis of antiarrhythmic therapy in the prevention of postoperative atrial fibrillation and the effect on hospital length of stay, costs, cerebrovascular accidents, and mortality in patients undergoing cardiac surgery. Am J Cardiol. 2003;91:1137–1140
  17. Auer J, Weber T, Berent R, et al. A comparison between oral antiarrhythmic drugs in the prevention of atrial fibrillation after cardiac surgery: the pilot study of prevention of postoperative atrial fibrillation (SPPAF), a randomized, placebo-controlled trial. Am Heart J. 2004;147:636–643
  18. Solomon AJ, Greenberg MD, Kilborn MJ, Katz NM. Amiodarone versus a beta-blocker to prevent atrial fibrillation after cardiovascular surgery. Am Heart J. 2001;142:811–815
  19. Halonen J, Hakala T, Auvinen T, et al. Intravenous administration of metoprolol is more effective than oral administration in the prevention of atrial fibrillation after cardiac surgery. Circulation. 2006;114:I1–4
  20. Yazigi A, Rahbani P, Zeid HA, Madi-Jebara S, Haddad F, Hayek G. Postoperative oral amiodarone as prophylaxis against atrial fibrillation after coronary artery surgery. J Cardiothorac Vasc Anesth. 2002;16:603–606
  21. Crystal E, Garfinkle M, Connolly S, Ginger T, Sleik K, Yusuf S. Interventions for preventing post-operative atrial fibrillation in patients undergoing heart surgery. Cochrane Database Syst Rev. 2004;CD003611
  22. Reiter MJ. Cardiovascular drug class specificity: [beta]-blockers. Prog Cardiovasc Dis. 2004;47:11
  23. Acikel S, Bozbas H, Gultekin B, et al. Comparison of the efficacy of metoprolol and carvedilol for preventing atrial fibrillation after coronary bypass surgery. Int J Cardiol. 2008;126:108–113
  24. Redle JD, Khurana S, Marzan R, et al. Prophylactic oral amiodarone compared with placebo for prevention of atrial fibrillation after coronary artery bypass surgery. Am Heart J. 1999;138:144–150
  25. Giri S, White CM, Dunn AB, et al. Oral amiodarone for prevention of atrial fibrillation after open heart surgery, the Atrial Fibrillation Suppression Trial (AFIST): a randomised placebo-controlled trial. Lancet. 2001;357:830–836
  26. Maras D, Boskovic SD, Popovic Z, et al. Single-day loading dose of oral amiodarone for the prevention of new-onset atrial fibrillation after coronary artery bypass surgery. Am Heart J. 2001;141:E8
  27. Burgess DC, Kilborn MJ, Keech AC. Interventions for prevention of post-operative atrial fibrillation and its complications after cardiac surgery: a meta-analysis. Eur Heart J. 2006;27:2846–2857
  28. Bagshaw SM, Galbraith PD, Mitchell LB, Sauve R, Exner DV, Ghali WA. Prophylactic amiodarone for prevention of atrial fibrillation after cardiac surgery: a meta-analysis. Ann Thorac Surg. 2006;82:1927–1937
  29. Crystal E, Thorpe KE, Connolly SJ, et al. Metoprolol prophylaxis against postoperative atrial fibrillation increases length of hospital stay in patients not on pre-operative beta blockers: the beta blocker length of stay (BLOS) trial. Heart. 2004;90:941–942
  30. Aranki SF, Shaw DP, Adams DH, et al. Predictors of atrial fibrillation after coronary artery surgery. Current trends and impact on hospital resources. Circulation. 1996;94:390–397
  31. Dublin S, French B, Glazer NL, et al. Risk of new-onset atrial fibrillation in relation to body mass index. Arch Intern Med. 2006;166:2322–2328
  32. Arias MA, Sanchez-Gila J, Amar D. Obesity as a risk factor for developing postoperative atrial fibrillation. Chest. 2006;129:828–829
  33. Zacharias A, Schwann TA, Riordan CJ, Durham SJ, Shah AS, Habib RH. Obesity and risk of new-onset atrial fibrillation after cardiac surgery. Circulation. 2005;112:3247–3255
  34. Mariscalco G, Engström KG. Atrial fibrillation after cardiac surgery: risk factors and their temporal relationship in prophylactic drug strategy decision. Int J Cardiol. 2008;129:354–362
  35. Jung W, Meyerfeldt U, Birkemeyer R. Atrial arrhythmias after cardiac surgery in patients with diabetes mellitus. Clin Res Cardiol. 2006;95:i88–i97
  36. Ferguson TB, Coombs LP, Peterson ED for the Society of Thoracic Surgeons National Adult Cardiac Surgery. Preoperative {beta}-blocker use and mortality and morbidity following CABG surgery in North America. JAMA. 2002;287:2221–2227
  37. Shantsila E, Watson T, Lip GY. Atrial fibrillation post-cardiac surgery: changing perspectives. Curr Med Res Opin. 2006;22:1437–1441
  38. Coats AJ. Ethical authorship and publishing. Int J Cardiol. 2009;131:149–150

☆ Partial results of this paper were presented as an abstract (<400 words) in the American Society of Anesthesiologists Annual Meeting 2006 (Available from www.asaabstracts.com).

PII: S0167-5273(08)00829-2

doi: 10.1016/j.ijcard.2008.06.034

International Journal of Cardiology
Volume 137, Issue 2 , Pages 116-122 , October 2009

Article Tools

* Image Usage & Resolution