International Journal of Cardiology
Volume 139, Issue 1 , Pages 50-59 , 18 February 2010

Effect of pregnancy on clinical status and ventricular function in women with heart disease

  • Anselm Uebing

      Affiliations

    • Adult Congenital Heart Disease Unit, Royal Brompton and Harefield NHS Trust, and the National Heart and Lung Institute at Imperial College, Sydney Street, London SW3 6NP, United Kingdom
    • Department of Paediatric Cardiology, University Hospital of Schleswig-Holstein, Campus Kiel, Schwanenweg 20, 24105 Kiel, Germany
    • Corresponding Author InformationCorresponding author. Department of Paediatric Cardiology, University Hospital of Schleswig-Holstein, Campus Kiel, Schwanenweg 20, 24105 Kiel, Germany. Tel.: +49 431 597 1727; fax: +49 431 597 1828.
    • ,
  • Panagiotis Arvanitis

      Affiliations

    • Adult Congenital Heart Disease Unit, Royal Brompton and Harefield NHS Trust, and the National Heart and Lung Institute at Imperial College, Sydney Street, London SW3 6NP, United Kingdom
    • ,
  • Wei Li

      Affiliations

    • Adult Congenital Heart Disease Unit, Royal Brompton and Harefield NHS Trust, and the National Heart and Lung Institute at Imperial College, Sydney Street, London SW3 6NP, United Kingdom
    • ,
  • Gerhard Paul Diller

      Affiliations

    • Adult Congenital Heart Disease Unit, Royal Brompton and Harefield NHS Trust, and the National Heart and Lung Institute at Imperial College, Sydney Street, London SW3 6NP, United Kingdom
    • ,
  • Sonya V. Babu-Narayan

      Affiliations

    • Adult Congenital Heart Disease Unit, Royal Brompton and Harefield NHS Trust, and the National Heart and Lung Institute at Imperial College, Sydney Street, London SW3 6NP, United Kingdom
    • ,
  • Darlington Okonko

      Affiliations

    • Adult Congenital Heart Disease Unit, Royal Brompton and Harefield NHS Trust, and the National Heart and Lung Institute at Imperial College, Sydney Street, London SW3 6NP, United Kingdom
    • ,
  • Evdokia Koltsida

      Affiliations

    • Adult Congenital Heart Disease Unit, Royal Brompton and Harefield NHS Trust, and the National Heart and Lung Institute at Imperial College, Sydney Street, London SW3 6NP, United Kingdom
    • ,
  • Michael Papadopoulos

      Affiliations

    • Adult Congenital Heart Disease Unit, Royal Brompton and Harefield NHS Trust, and the National Heart and Lung Institute at Imperial College, Sydney Street, London SW3 6NP, United Kingdom
    • ,
  • Mark R. Johnson

      Affiliations

    • Academic Department of Obstetrics and Gynaecology, at Chelsea and Westminster Hospital, Division of Surgery, Oncology, Reproductive Medicine and Anaesthetics, Faculty of Medicine, Imperial College London, 369 Fulham Road, London SW10 9NH, United Kingdom
    • ,
  • Martin G. Lupton

      Affiliations

    • Academic Department of Obstetrics and Gynaecology, at Chelsea and Westminster Hospital, Division of Surgery, Oncology, Reproductive Medicine and Anaesthetics, Faculty of Medicine, Imperial College London, 369 Fulham Road, London SW10 9NH, United Kingdom
    • ,
  • Steve M. Yentis

      Affiliations

    • Magill Department of Anaesthesia, Intensive Care and Pain Management, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    • ,
  • Philip J. Steer

      Affiliations

    • Academic Department of Obstetrics and Gynaecology, at Chelsea and Westminster Hospital, Division of Surgery, Oncology, Reproductive Medicine and Anaesthetics, Faculty of Medicine, Imperial College London, 369 Fulham Road, London SW10 9NH, United Kingdom
    • ,
  • Michael A. Gatzoulis

      Affiliations

    • Adult Congenital Heart Disease Unit, Royal Brompton and Harefield NHS Trust, and the National Heart and Lung Institute at Imperial College, Sydney Street, London SW3 6NP, United Kingdom

Received 18 November 2007 ,Revised 18 July 2008 ,Accepted 2 September 2008.

References 

  1. Hoffman JI, Kaplan S, Liberthson RR. Prevalence of congenital heart disease. Am Heart J. 2004;147:425–439
  2. Uebing A, Steer PJ, Yentis SM, Gatzoulis MA. Pregnancy and congenital heart disease. BMJ. 2006;332:401–406
  3. Oakley CM. Pregnancy and congenital heart disease. Heart. 1997;78:12–14
  4. Siu SC, Sermer M, Harrison DA, et al. Risk and predictors for pregnancy-related complications in women with heart disease. Circulation. 1997;96:2789–2794
  5. Siu SC, Sermer M, Colman JM, et al. Prospective multicenter study of pregnancy outcomes in women with heart disease. Circulation. 2001;104:515–521
  6. Siu SC, Colman JM, Sorensen S, et al. Adverse neonatal and cardiac outcomes are more common in pregnant women with cardiac disease. Circulation. 2002;105:2179–2184
  7. Khairy P, Ouyang DW, Fernandes SM, Lee-Parritz A, Economy KE, Landzberg MJ. Pregnancy outcomes in women with congenital heart disease. Circulation. 2006;113:517–524
  8. Connolly HM, Warnes CA. Outcome of pregnancy in patients with complex pulmonic valve atresia. Am J Cardiol. 1997;79:519–521
  9. Beauchesne LM, Connolly HM, Ammash NM, Warnes CA. Coarctation of the aorta: outcome of pregnancy. J Am Coll Cardiol. 2001;38:1728–1733
  10. Connolly HM, Grogan M, Warnes CA. Pregnancy among women with congenitally corrected transposition of great arteries. J Am Coll Cardiol. 1999;33:1692–1695
  11. Veldtman GR, Connolly HM, Grogan M, Ammash NM, Warnes CA. Outcomes of pregnancy in women with tetralogy of Fallot. J Am Coll Cardiol. 2004;44:174–180
  12. Hameed A, Karaalp IS, Tummala PP, et al. The effect of valvular heart disease on maternal and fetal outcome of pregnancy. J Am Coll Cardiol. 2001;37:893–899
  13. Lewis G, Drife JO. Why Mothers Die 2000–2002 — The Sixth Report of Confidential Enquiries into Maternal Deaths in the United Kingdom. London: RCOG Press; 2004;
  14. Bolger AP, Sharma R, Li W, et al. Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease. Circulation. 2002;106:92–99
  15. Puley G, Siu S, Connelly M, et al. Arrhythmia and survival in patients >18 years of age after the mustard procedure for complete transposition of the great arteries. Am J Cardiol. 1999;83:1080–1084
  16. Guedes A, Mercier LA, Leduc L, Berube L, Marcotte F, Dore A. Impact of pregnancy on the systemic right ventricle after a Mustard operation for transposition of the great arteries. J Am Coll Cardiol. 2004;44:433–437
  17. Li W, Davlouros PA, Kilner PJ, et al. Doppler-echocardiographic assessment of pulmonary regurgitation in adults with repaired tetralogy of Fallot: comparison with cardiovascular magnetic resonance imaging. Am Heart J. 2004;147:165–172
  18. Miyatake K, Izumi S, Okamoto M, et al. Semiquantitative grading of severity of mitral regurgitation by real-time two-dimensional Doppler flow imaging technique. J Am Coll Cardiol. 1986;7:82–88
  19. Perry GJ, Helmcke F, Nanda NC, Byard C, Soto B. Evaluation of aortic insufficiency by Doppler color flow mapping. J Am Coll Cardiol. 1987;9:952–959
  20. Tribouilloy CM, Enriquez-Sarano M, Bailey KR, Tajik AJ, Seward JB. Quantification of tricuspid regurgitation by measuring the width of the vena contracta with Doppler color flow imaging: a clinical study. J Am Coll Cardiol. 2000;36:472–478
  21. Katz R, Karliner JS, Resnik R. Effects of a natural volume overload state (pregnancy) on left ventricular performance in normal human subjects. Circulation. 1978;58:434–441
  22. Mone SM, Sanders SP, Colan SD. Control mechanisms for physiological hypertrophy of pregnancy. Circulation. 1996;94:667–672
  23. Campos O. Doppler echocardiography during pregnancy: physiological and abnormal findings. Echocardiography. 1996;13:135–146
  24. Robson SC, Hunter S, Boys RJ, Dunlop W. Serial study of factors influencing changes in cardiac output during human pregnancy. Am J Physiol. 1989;256:H1060–1065
  25. Sanchez-Quintana D, Anderson RH, Ho SY. Ventricular myoarchitecture in tetralogy of Fallot. Heart. 1996;76:280–286
  26. Roos-Hesselink JW, Meijboom FJ, Spitaels SE, et al. Decline in ventricular function and clinical condition after Mustard repair for transposition of the great arteries (a prospective study of 22–29 years). Eur Heart J. 2004;25:1264–1270
  27. Warnes CA. The adult with congenital heart disease: born to be bad?. J Am Coll Cardiol. 2005;46:1–8
  28. Coats AJ. Ethical authorship and publishing. Int J Cardiol. 2009;131:149–150

PII: S0167-5273(08)01014-0

doi: 10.1016/j.ijcard.2008.09.001

International Journal of Cardiology
Volume 139, Issue 1 , Pages 50-59 , 18 February 2010

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