International Journal of Cardiology
Volume 139, Issue 2 , Pages 159-165, 4 March 2010

The metabolic syndrome increased risk of cardiovascular events in Chinese—A community based study☆

  • Chen Wang

      Affiliations

    • Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital; Shanghai Diabetes Institute; Shanghai Clinical Center of Diabetes, Shanghai, China
    • ,
  • Xuhong Hou

      Affiliations

    • Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital; Shanghai Diabetes Institute; Shanghai Clinical Center of Diabetes, Shanghai, China
    • ,
  • Yuqian Bao

      Affiliations

    • Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital; Shanghai Diabetes Institute; Shanghai Clinical Center of Diabetes, Shanghai, China
    • ,
  • Jiemin Pan

      Affiliations

    • Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital; Shanghai Diabetes Institute; Shanghai Clinical Center of Diabetes, Shanghai, China
    • ,
  • Yuhua Zuo

      Affiliations

    • Caoyang Health Center, Shanghai, China
    • ,
  • Wenhong Zhong

      Affiliations

    • Huayang Health Center, Shanghai, China
    • ,
  • Weiping Jia

      Affiliations

    • Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital; Shanghai Diabetes Institute; Shanghai Clinical Center of Diabetes, Shanghai, China
    • Corresponding Author InformationCorresponding author. Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China. Tel.: +86 21 64369181 8922; fax: +86 21 64368031.
    • ,
  • Kunsan Xiang

      Affiliations

    • Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital; Shanghai Diabetes Institute; Shanghai Clinical Center of Diabetes, Shanghai, China

Received 3 April 2008; received in revised form 22 July 2008; accepted 12 October 2008. published online 01 December 2008.

Abstract 

Background

Whether metabolic syndrome (MetS) could serve as a valid indicator for cardiovascular disease (CVD) is in controversy. The aim of the study was to prospectively evaluate the predictive value of the MetS for CVD events in Chinese population by different MetS definitions.

Methods

This was a community-based cohort study. MetS was defined according to the World Health Organization (WHO), the International Diabetes Federation (IDF), the National Cholesterol Education Program Adult Treatment Panel III (NCEPIII) and Joint Committee for Developing Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults (JCDCG), respectively. 2788 subjects were included. The incidence of CVD events was monitored during a 5.5-year period.

Results

The proportion of MetS defined by the WHO, IDF, NCEPIII and JCDCG criteria was 25.9%, 15.4%, 22.0% and 26.1%, respectively in men, and 24.5%, 28.0%, 31.1% and 23.0%, respectively in women. After adjusting for age, all four definitions were associated with increased risk of CVD events in women, but not in men. The corresponding hazard ratios (HRs) [95% confidence intervals (CIs)] in women were 2.13 (1.44–3.16), 1.49 (1.01–2.19), 1.50 (1.02–2.21) and 2.10 (1.41–3.11). The HRs remained significant with WHO and JCDCG definitions, not with the IDF and NCEPIII definitions, when factors of LDL cholesterol, and smoking were adjusted.

Conclusion

The MetS by the WHO and JCDCG definition was associated with increased risk of CVD events in Chinese women after adjustment for age, total cholesterol, LDL cholesterol, and smoking.

Keywords: Metabolic syndrome, Cardiovascular disease, Hazard ratio

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☆ This work was funded by the Key Project from Science and Technology Commission of Shanghai Municipality (04DZ19501) and by National Basic Research Program of China (973 Program) (2006CB503901).

PII: S0167-5273(08)01071-1

doi:10.1016/j.ijcard.2008.10.012

International Journal of Cardiology
Volume 139, Issue 2 , Pages 159-165, 4 March 2010

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