International Journal of Cardiology
Volume 135, Issue 3 , Pages 386-390 , 10 July 2009

Increased nitrotyrosine plasma levels in relation to systemic markers of inflammation and myeloperoxidase in chronic heart failure

  • Ermanno Eleuteri

      Affiliations

    • Divisione di Cardiologia Riabilitativa e Laboratorio di Citoimmunopatologia Apparato Cardio-Respiratorio, Fondazione Salvatore Maugeri, IRCCS, Veruno (NO), Italy
    • Corresponding Author InformationCorresponding author. Divisione di Cardiologia Riabilitativa, Fondazione Salvatore Maugeri, IRCCS, Via per Revislate 13, 28010 Veruno (NO), Italy. Tel.: +39 0322 884914; fax: +39 0322 884966.
    • The first two authors (E.E., A.D.S.) contributed equally to the current work.
    • ,
  • Antonino Di Stefano

      Affiliations

    • Divisione di Cardiologia Riabilitativa e Laboratorio di Citoimmunopatologia Apparato Cardio-Respiratorio, Fondazione Salvatore Maugeri, IRCCS, Veruno (NO), Italy
    • The first two authors (E.E., A.D.S.) contributed equally to the current work.
    • ,
  • Fabio LM Ricciardolo

      Affiliations

    • Divisione di Pneumologia, Università degli studi di Torino; Italy
    • ,
  • Francesca Magno

      Affiliations

    • Divisione di Cardiologia Riabilitativa e Laboratorio di Citoimmunopatologia Apparato Cardio-Respiratorio, Fondazione Salvatore Maugeri, IRCCS, Veruno (NO), Italy
    • ,
  • Isabella Gnemmi

      Affiliations

    • Divisione di Cardiologia Riabilitativa e Laboratorio di Citoimmunopatologia Apparato Cardio-Respiratorio, Fondazione Salvatore Maugeri, IRCCS, Veruno (NO), Italy
    • ,
  • Marilena Colombo

      Affiliations

    • Divisione di Cardiologia Riabilitativa e Laboratorio di Citoimmunopatologia Apparato Cardio-Respiratorio, Fondazione Salvatore Maugeri, IRCCS, Veruno (NO), Italy
    • ,
  • Rita Anzalone

      Affiliations

    • Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale, Università di Palermo, Italy
    • ,
  • Francesco Cappello

      Affiliations

    • Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale, Università di Palermo, Italy
    • ,
  • Giampiero La Rocca

      Affiliations

    • Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale, Università di Palermo, Italy
    • ,
  • Francesco Tarro Genta

      Affiliations

    • Divisione di Cardiologia Riabilitativa, Clinica Maior, Torino, Italy
    • ,
  • Giovanni Zummo

      Affiliations

    • Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale, Università di Palermo, Italy
    • ,
  • Pantaleo Giannuzzi

      Affiliations

    • Divisione di Cardiologia Riabilitativa e Laboratorio di Citoimmunopatologia Apparato Cardio-Respiratorio, Fondazione Salvatore Maugeri, IRCCS, Veruno (NO), Italy

Received 7 May 2008 ,Revised 28 October 2008 ,Accepted 1 November 2008.

References 

  1. Cai H. Hydrogen peroxide regulation of endothelial function: origin, mechanism and consequences. Cardiovasc Res. 2005;68:26–36
  2. Bradley JR, Johnson DR, Pober JS. Endothelial activation by hydrogen peroxide. Am J Pathol. 1993;142:1598–1609
  3. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases. The role of oxidant stress. Circ Res. 2000;87:840–844
  4. Mann DL, Reid MB. Exercise training and skeletal muscle inflammation in chronic heart failure: feeling better about fatigue. J Am Coll Cardiol. 2003;42:869–872
  5. Adams V, Nehrhoff B, Spate U, Linke A, Schulze PC, Baur A. Induction of iNOS expression in skeletal muscle by IL-1β and NF-KB activation: an in vitro and in vivo study. Cardiovasc Res. 2002;54:95–104
  6. Vita JA, Brennan ML, Goke N. Serum myeloperoxidase levels independently predict endothelial dysfunction in humans. Circulation. 2004;110:1134–1139
  7. Hare JM, Stamler JS. NO/redox disequilibrium in the failing heart and cardiovascular system. J Clin Invest. 2005;115:509–517
  8. Levine B, Kalman J, Mayer L, Fillit HM, Packer M. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med. 1990;323:236–241
  9. Tendera M, Wysocki H. TNF-α in patients with chronic heart failure is not only a proinflammatory cytokine. Eur Heart J. 1999;20:1445–1446
  10. Ricciardolo FLM, Di Stefano A, Sabatini F, Folkerts G. Reactive nitrogen species in the respiratory tract. Eur J Pharmacol. 2006;533:240–252
  11. Colombo PC, Banchs JE, Celaj S. Endothelial cell activation in patients with decompensated heart failure. Circulation. 2005;111:58–62
  12. Hambrecht R, Adams V, Gielen S. Exercise intolerance in patients with chronic heart failure and increased expression of inducibile nitric oxide synthase in the skeletal muscle. J Am Coll Cardiol. 1999;33:174–179
  13. Leftheriotis DI, Fountoulaki KT, Flevari PG, et al. The predictive value of inflammatory and oxidative markers following the successful cardioversion of persistent lone atrial fibrillation. Int J Cardiol. 2009;135:361–369
  14. Han W, Fu S, Wei N, Xei B, et al. Nitric oxide overproduction derived from inducible nitric oxide synthase increases cardiomyocyte apoptosis in human atrial fibrillation. Int J Cardiol. 2008;130:165–173

PII: S0167-5273(08)01169-8

doi: 10.1016/j.ijcard.2008.11.013

International Journal of Cardiology
Volume 135, Issue 3 , Pages 386-390 , 10 July 2009

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