International Journal of Cardiology
Volume 143, Issue 2 , Pages 154-157 , 20 August 2010

Coronary endothelial dysfunction associated with a depressive mood in patients with atypical angina but angiographically normal coronary artery

  • Ji Hoon Kim

      Affiliations

    • Cardiovascular Center, Korea University Guro Hospital, 97, Guro-dong, Guro-gu, Seoul, 152-703, Republic of Korea
  • ,
  • Jin Won Kim

      Affiliations

    • Cardiovascular Center, Korea University Guro Hospital, 97, Guro-dong, Guro-gu, Seoul, 152-703, Republic of Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 2 818 6635; fax: +82 2 818 6411.
  • ,
  • Young Hoon Ko

      Affiliations

    • Department of Psychiatry, Korea University Guro Hospital, 97, Guro-dong, Guro-gu, Seoul, 152-703, Republic of Korea
  • ,
  • Cheol Ung Choi

      Affiliations

    • Cardiovascular Center, Korea University Guro Hospital, 97, Guro-dong, Guro-gu, Seoul, 152-703, Republic of Korea
  • ,
  • Jin Oh Na

      Affiliations

    • Cardiovascular Center, Korea University Guro Hospital, 97, Guro-dong, Guro-gu, Seoul, 152-703, Republic of Korea
  • ,
  • Eung Ju Kim

      Affiliations

    • Cardiovascular Center, Korea University Guro Hospital, 97, Guro-dong, Guro-gu, Seoul, 152-703, Republic of Korea
  • ,
  • Seung-Woon Rha

      Affiliations

    • Cardiovascular Center, Korea University Guro Hospital, 97, Guro-dong, Guro-gu, Seoul, 152-703, Republic of Korea
  • ,
  • Chang Gyu Park

      Affiliations

    • Cardiovascular Center, Korea University Guro Hospital, 97, Guro-dong, Guro-gu, Seoul, 152-703, Republic of Korea
  • ,
  • Hong Seog Seo

      Affiliations

    • Cardiovascular Center, Korea University Guro Hospital, 97, Guro-dong, Guro-gu, Seoul, 152-703, Republic of Korea
  • ,
  • Dong Joo Oh

      Affiliations

    • Cardiovascular Center, Korea University Guro Hospital, 97, Guro-dong, Guro-gu, Seoul, 152-703, Republic of Korea

Received 20 June 2008 ,Revised 9 January 2009 ,Accepted 6 February 2009.

References 

  1. Ramachandruni S, Fillingim RB, McGorray SP, et al. Mental stress provokes ischemia in coronary artery disease subjects without exercise- or adenosine-induced ischemia. J Am Coll Cardiol. 2006;47:987–991
  2. Lett HS, Blumenthal JA, Babyak MA, et al. Depression as a risk factor for coronary artery disease: evidence, mechanisms, and treatment. Psychosom Med. 2004;66:305–315
  3. Broadley AJ, Korszun A, Jones CJ, Frenneaux MP. Arterial endothelial function is impaired in treated depression. Heart. 2002;88:521–523
  4. Rajagopalan S, Brook R, Rubenfire M, Pitt E, Young E, Pitt B. Abnormal brachial artery flow-mediated vasodilation in young adults with major depression. Am J Cardiol. 2001;88:196–198A7
  5. Sherwood A, Hinderliter AL, Watkins LL, Waugh RA, Blumenthal JA. Impaired endothelial function in coronary heart disease patients with depressive symptomatology. J Am Coll Cardiol. 2005;46:656–659
  6. Anderson TJ, Uehata A, Gerhard MD, et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol. 1995;26:1235–1241
  7. Broadley AJ, Korszun A, Abdelaal E, et al. Metyrapone improves endothelial dysfunction in patients with treated depression. J Am Coll Cardiol. 2006;48:170–175
  8. Pizzi C, Manzoli L, Mancini S, et al. Analysis of potential predictors of depression among coronary heart disease risk factors including heart rate variability, markers of inflammation, and endothelial function. Eur Heart J. 2008;29:1110–1117
  9. Yang EH, Lennon SL, Simari RD, et al. Relation of depression to coronary endothelial function. Am J Cardiol. 2007;99:1134–1136
  10. Joynt KE, Whellan DJ, O'Connor CM. Depression and cardiovascular disease: mechanisms of interaction. Biol Psychiatry. 2003;54:248–261
  11. Hughes JW, Casey E, Luyster F, et al. Depression symptoms predict heart rate recovery after treadmill stress testing. Am Heart J. 2006;151(1122):e1–e6
  12. Christensen NJ. Adrenergic mechanisms in selected diseases: arterial hypertension, duodenal ulcer, primary depressive illness, malignant tumors, and ketotic hypoglycemia. Metabolism. 1980;29:1190–1197
  13. Gotthardt U, Schweiger U, Fahrenberg J, Lauer CJ, Holsboer F, Heuser I. Cortisol, ACTH, and cardiovascular response to a cognitive challenge paradigm in aging and depression. Am J Physiol. 1995;268:R865–R873
  14. Lahlou-Laforet K, Alhenc-Gelas M, Pornin M, et al. Relation of depressive mood to plasminogen activator inhibitor, tissue plasminogen activator, and fibrinogen levels in patients with versus without coronary heart disease. Am J Cardiol. 2006;97:1287–1291
  15. Parissis JT, Adamopoulos S, Rigas A, et al. Comparison of circulating proinflammatory cytokines and soluble apoptosis mediators in patients with chronic heart failure with versus without symptoms of depression. Am J Cardiol. 2004;94:1326–1328
  16. Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol. 2003;23:168–175
  17. Pristipino C, Beltrame JF, Finocchiaro ML, et al. Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction. Circulation. 2000;101:1102–1108
  18. Coats AJ. Ethical authorship and publishing. Int J Cardiol. 2009;131:149–150

 This study was supported by a Special Research Grant from Korea University, Seoul to Jin Won Kim.

PII: S0167-5273(09)00159-4

doi: 10.1016/j.ijcard.2009.02.004

International Journal of Cardiology
Volume 143, Issue 2 , Pages 154-157 , 20 August 2010