International Journal of Cardiology
Volume 143, Issue 2 , Pages 171-177 , 20 August 2010

Effects of cardiotrophin-1 on differentiation and maturation of rat bone marrow mesenchymal stem cells induced with 5-azacytidine in vitro

  • Chen Xinyun

      Affiliations

    • Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, China
    • Department of Cardiology, The No.1 municipal Hospital of Chendu, Chengdu 610041, China
    • ,
  • Zeng Zhi

      Affiliations

    • Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 28 15828179639; fax: +86 28 85315539.
    • ,
  • Zhou Bin

      Affiliations

    • Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, China
    • ,
  • Rao Li

      Affiliations

    • Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, China
    • ,
  • Chen Yucheng

      Affiliations

    • Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, China
    • ,
  • Yan Yafei

      Affiliations

    • Department of Cardiology, The No.1 municipal Hospital of Chendu, Chengdu 610041, China
    • ,
  • Zhang Tingjie

      Affiliations

    • Department of Cardiology, The No.1 municipal Hospital of Chendu, Chengdu 610041, China
    • ,
  • Li Shengfu

      Affiliations

    • Key Laboratory of Transplant Engineering and Immunology of Ministry of Health, West China Hospital, Sichuan University, Chengdu, 610041, China

Received 9 October 2008 ,Revised 9 December 2008 ,Accepted 6 February 2009.

References 

  1. Rosamond W, Flegal K, Furie K, et al. Heart Disease and Stroke Statistics—2007 Update. Circulation. 2007;115:69–171
  2. Minguell JJ, Erices A. Mesenchymal stem cells and the treatment of cardiac disease. Exp Biol Med. 2006;231:39–49
  3. Wang T, Xu Z, Jiang W, Ma A. Cell-to-cell contact induces mesenchymal stem cell to differentiate into cardiomyocyte and smooth muscle cell. Int J Cardiol. 2006;109:74–81
  4. Shim WS, Jiang S, Wong P, et al. Ex vivo differentiation of human adult bone marrow stem cells into cardiomyocyte-like cell. Biochem Biophys Res Commun. 2004;324:481–488
  5. Siminiak T, Fiszer D, Jerzykowska O, Grygielska B, Kałmucki P, Kurpisz M. Percutaneous autologous myoblast transplantation in the treatment of post-infarction myocardial contractility impairment — report on two cases. Kardiol Pol. 2003;59(12):492–501
  6. Siminiak T, Grygielska B, Jerzykowska O, et al. Autologous bone marrow stem cell transplantation in acute myocardial infarction — report on two cases. Kardiol Pol. 2003;59(12):502–510
  7. Uemura R, Xu M, Ahmad N, Ashraf M. Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling. Circ Res. 2006;98:1414–1421
  8. Fukuhara S, Tomita S, Yamashiro S, et al. Direct cell–cell interaction of cardiomyocytes is a key for bone marrow stromal cells to go into cardiac lineage in vitro. J Thorac Cardiovasc Surg. 2003;125:1470–1480
  9. Freed DH, Moon MC, Borowiec AM, Jones SC, Zahradka P, Dixon IM. Cardiotrophin-1: expression in experimental myocardial infarction and potential role in post-MI wound healing. Mol Cell Biochem. 2003;254(1–2):247–256
  10. Takahashi N, Saito Y, Kuwahara K, et al. Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5–ERK5 pathway in cultured cardiomyocytes. J Mol Cell Cardiol. 2005;38(1):185–192
  11. Freed DH, Borowied AM, Angelovska T, Dixon IM. Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways. Cardiovasc Res. 2003;60(2):365–375
  12. Pennica D, Shaw KJ, Swanson TA, et al. Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130-signaling complex. J Biol Chem. 1995;270(18):10915–10922
  13. Sauer H, Neukirchen W, Rahimi G, Grünheck F, Hescheler J, Wartenberg M. Involvement of reactive oxygen species in cardiotrophin-1-induced proliferation of cardiomyocytes differentiated from murine ES cells. Exp Cell Res. 2004;294:313–324
  14. Caplan AI. Mesenchymal stem cells and gene therapy. Clin Orthop Relat Res. 2000;379:67–70[Suppl]
  15. Wakitani S, Saito T, Caplan AI. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve. 1995;18:1417–1426
  16. Rangappa S, Reddy VG, Bongso A, Lee EH, Sim EKW. Transformation of the adult human mesenchymal stem cells into cardiomyocyte-like cells in vivo. Cardiovasc Eng. 2002;2:7–14
  17. Fukuda K. Reprogramming of bone marrow mesenchymal stem cells into cardiomyocytes. C R Biol. 2002;325:1027–1038
  18. Freed DH, Cunnington RH, Dangerfield AL, Sutton JS, Dixon IM. Emerging evidence for the role of cardiotrophin-1 in cardiac repair in the infarcted heart. Cardiovasc Res. 2005;65(4):782–792
  19. Wollert KC, Taga T, Saito M, et al. Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways. J Biol Chem. 1996;271(16):9535–9545
  20. Lyons I, Parsons LM, Hartley L, et al. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2.5. Genes Dev. 1995;91654–91666
  21. Cleaver OD, Patterson KD, Krieg PA. Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia. Development. 1996;122:3549–3556
  22. Oka T, Xu J, Molkentin JD. Reemployment of developmental transcription factors in adult heart disease. Semin Cell Dev Biol. 2007;18:117–131
  23. Kuo CT, Morrisey EE, Anandappa R. GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 1997;11(8):1048–1060
  24. Molkentin JD, Lin Q, Duncan SA, Olson EN. Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 1997;11(8):1061–1072
  25. Gre'pin , Nemer G, Nemer M. Enhanced cardiogenesis in ES cells overexpressing the GATA4 transcription factor. Development. 1997;124(12):2387–2395
  26. Durocher D, Charron F, Warren R, Schwartz RJ, Nemer M. The cardiac transcription factors Nkx2.5 and GATA4 are mutual cofactors. EMBO J. 1997;16(18):5687–5696
  27. Pennica D, King KL, Shaw KJ, et al. Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc Natl Acad Sci U S A. 1995;14(92(4)):1142–1146
  28. Zolk Oliver, Engmann Sven, Münzel Felix, Krajcik Rasti. Chronic cardiotrophin-1 stimulation impairs contractile function in reconstituted heart tissue. Am J Physiol: Endocrinol Metab. 2005;288:E1214–E1221
  29. Yuan Yan, Chen Lianfeng, Zhang Shuyang, Wu Wei, Chen Hao, Yan Xiaowei. Differentiation of mesenchymal stem cells into cardiomyogenic cells under the induction of myocardial cell lysate. Chin J Cardiol. 2005;33(2):170–174
  30. Coats AJ. Ethical authorship and publishing. Int J Cardiol. 2009;131:149–150

PII: S0167-5273(09)00162-4

doi: 10.1016/j.ijcard.2009.02.009

International Journal of Cardiology
Volume 143, Issue 2 , Pages 171-177 , 20 August 2010

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