International Journal of Cardiology
Volume 145, Issue 2 , Pages 365-367, 19 November 2010

Androgens and atrial fibrillation: Friends or foes?

  • Tong Liu

      Affiliations

    • Heart Rhythm Center, the Heart Institute, Cedars-Sinai Health System, Los Angeles, CA, 90048, USA
    • Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People's Republic of China
    • ,
  • Michael Shehata

      Affiliations

    • Heart Rhythm Center, the Heart Institute, Cedars-Sinai Health System, Los Angeles, CA, 90048, USA
    • ,
  • Guangping Li

      Affiliations

    • Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People's Republic of China
    • ,
  • Xunzhang Wang

      Affiliations

    • Heart Rhythm Center, the Heart Institute, Cedars-Sinai Health System, Los Angeles, CA, 90048, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 310 423 4856; fax: +1 310 423 6795.

Received 23 December 2009; accepted 14 February 2010. published online 10 March 2010.

Abstract 

Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice. The prevalence of AF increases with age, and this age-specific prevalence is higher in men than in women. However, the mechanisms of aging-induced AF have not been fully elucidated, and this may be related to decline of testosterone with advancing age. On the other hand, anabolic steroid abuse may precipitate the occurrence of AF. Until now, the possible relationship between androgens and AF was not comprehensively reviewed. We intend to review some recent evidence on this issue and propose some potential mechanisms.

Keywords: Androgens, Testosterone, Atrial fibrillation

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PII: S0167-5273(10)00106-3

doi:10.1016/j.ijcard.2010.02.039

International Journal of Cardiology
Volume 145, Issue 2 , Pages 365-367, 19 November 2010

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