International Journal of Cardiology
Volume 152, Issue 2 , Pages 196-201 , 20 October 2011

Cardioprotective effect of dexrazoxane in a rat model of myocardial infarction: Anti-apoptosis and promoting angiogenesis

  • Ligang Zhou

      Affiliations

    • Department of Cardiology, Children's Hospital of Chongqing Medical University, Chongqing, P.R. China
    • These authors contributed equally to this manuscript.
    • ,
  • Rita Yn Tz Sung

      Affiliations

    • Li Ka Shing Institute of Health Sciences, Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong
    • These authors contributed equally to this manuscript.
    • ,
  • Karen Li

      Affiliations

    • Li Ka Shing Institute of Health Sciences, Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong
    • These authors contributed equally to this manuscript.
    • ,
  • Nga Hin Pong

      Affiliations

    • Li Ka Shing Institute of Health Sciences, Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong
    • ,
  • Ping Xiang

      Affiliations

    • Department of Cardiology, Children's Hospital of Chongqing Medical University, Chongqing, P.R. China
    • ,
  • Jie Shen

      Affiliations

    • Department of Paediatrics, Daping Hospital & Research Institute of Surgery of Third Military Medical University, Chongqing, P.R. China
    • ,
  • Pak Cheung Ng

      Affiliations

    • Li Ka Shing Institute of Health Sciences, Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong
    • ,
  • Yuan Chen

      Affiliations

    • Department of Cardiology, Children's Hospital of Chongqing Medical University, Chongqing, P.R. China
    • Corresponding Author InformationCorresponding author. Department of Cardiology, Children's Hospital of Chongqing Medical University, 136 Zhongshan Er Road, Yuzhong District, Chongqing, PR China. Tel.: +86 6363 1938; fax: +86 6362 2874.

Received 15 March 2010 ,Revised 18 May 2010 ,Accepted 4 July 2010.

References 

  1. Kumar D, Lou H, Singal PK. Oxidative stress and apoptosis in heart dysfunction. Herz. 2002;27:662–668
  2. Hare JM. Oxidative stress and apoptosis in heart failure progression. Circ Res. 2001;89:198–200
  3. Singal PK, Khaper N, Palace V, Kumar D. The role of oxidative stress in the genesis of heart disease. Cardiovasc Res. 1998;40:426–432
  4. Haunstetter A, Izumo S. Apoptosis: basic mechanisms and implications for cardiovascular disease. Circ Res. 1998;82:1111–1129
  5. Gustafsson AB, Gottlieb RA. Heart mitochondria: gates of life and death. Cardiovasc Res. 2008;77:334–343
  6. Hochhauser E, Kivity S, Offen D, et al. Bax ablation protects against myocardial ischemia–reperfusion injury in transgenic mice. Am J Physiol Heart Circ Physiol. 2003;284:2351–2359
  7. Shantsila E, Watson T, Lip GY. Endothelial progenitor cells in cardiovascular disorders. J Am Coll Cardiol. 2007;49:741–752
  8. Leone AM, Valgimigli M, Giannico MB, et al. From bone marrow to the arterial wall: the ongoing tale of endothelial progenitor cells. Eur Heart J. 2009;30:890–899
  9. Schuh A, Liehn EA, Sasse A, et al. Transplantation of endothelial progenitor cells improves neovascularization and left ventricular function after myocardial infarction in a rat model. Basic Res Cardiol. 2008;103:69–77
  10. Schächinger V, Erbs S, Elsässer A, et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med. 2006;355:1210–1221
  11. Xiang P, Deng HY, Li K, et al. Dexrazoxane protects against doxorubicin-induced cardiomyopathy: upregulation of Akt and Erk phosphorylation in a rat model. Cancer Chemother Pharmacol. 2009;63:343–349
  12. Kane RC, McGuinn WD, Dagher R, Justice R, Pazdur R. Dexrazoxane (Totect): FDA review and approval for the treatment of accidental extravasation following intravenous anthracycline chemotherapy. Oncologist. 2008;13:445–450
  13. Hasinoff BB, Herman EH. Dexrazoxane: how it works in cardiac and tumor cells. Is it a prodrug or is it a drug?. Cardiovasc Toxicol. 2007;140–144
  14. Hasinoff BB. Dexrazoxane (ICRF-187) protects cardiac myocytes against hypoxia–reoxygenation damage. Cardiovasc Toxicol. 2002;2:111–118
  15. Ramu E, Korach A, Houminer E, Schneider A, Elami A, Schwalb H. Dexrazoxane prevents myocardial ischemia/reperfusion-induced oxidative stress in the rat heart. Cardiovasc Drugs Ther. 2006;20:343–348
  16. Weisman HF, Bush DE, Mannisi JA, Weisfeldt ML, Healy B. Cellular mechanism of myocardial infarct expansion. Circulation. 1988;78:186–201
  17. Li K, Sung RY, Huang WZ, et al. Thrombopoietin protects against in vitro and in vivo cardiotoxicity induced by doxorubicin. Circulation. 2006;2211–2220
  18. Shao ZQ, Takaji K, Katayama Y, et al. Effects of intramyocardial administration of slow-release basic fibroblast growth factor on angiogenesis and ventricular remodeling in a rat infarct model. Circ J. 2006;70:471–477
  19. Liu JF, Wang BW, Hung HF, Chang H, Shyu KG. Human mesenchymal stem cells improve myocardial performance in a splenectomized rat model of chronic myocardial infarction. J Formos Med Assoc. 2008;107:165–174
  20. Imanishi Y, Saito A, Komoda H, et al. Allogenic mesenchymal stem cell transplantation has a therapeutic effect in acute myocardial infarction in rats. J Mol Cell Cardiol. 2008;44:662–671
  21. Yoder MC, Mead LE, Prater D, et al. Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood. 2007;109:1801–1809
  22. Marty M, Espie M, Llombart A, et al. Multicenter randomized phase III study of the cardioprotective effect of dexrazoxane (Cardioxane) in advanced/metastatic breast cancer patients treated with anthracycline-based chemotherapy. Ann Oncol. 2006;17:614–622
  23. Xiang P, Song YZ, Chen Y, Tu L, Zhu GH. Methods on enhancing success rate and survival rate of rat model of myocardial infarction. Acta Acad Med Mil Tertiae. 2008;4:329–332
  24. Jia YZ, Sato S. Evaluation of coronary collateral circulation in early ischemia in rat hearts. A morphological study. Nippon Ika Daigaku Zasshi. 1997;64:329–336
  25. Cesselli D, Jakoniuk I, Barlucchi L, et al. Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy. Circ Res. 2001;89:279–286
  26. Maulik N. Reactive oxygen species drives myocardial angiogenesis?. Antioxid Redox Signal. 2006;8:2161–2168
  27. Maloney SL, Sullivan DC, Suchting S, et al. Induction of thrombospondin-1 partially mediates the anti-angiogenic activity of dexrazoxane. Br J Cancer. 2009;101:957–966
  28. Coats AJ. Ethical authorship and publishing. Int J Cardiol. 2009;131:149–150

PII: S0167-5273(10)00542-5

doi: 10.1016/j.ijcard.2010.07.015

International Journal of Cardiology
Volume 152, Issue 2 , Pages 196-201 , 20 October 2011

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