International Journal of Cardiology
Volume 154, Issue 3 , Pages e60-e61, 9 February 2012

Sinus venosus defect (SVD) identified in zebrafish Glut1 morphants by video imaging

  • Ping-Pin Zheng

      Affiliations

    • Departments of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    • Corresponding Author InformationCorresponding author at: Department of Pathology, Erasmus Medical Center, Office JNI Room 262-a, Dr. Molewaterplein 50, PO Box 1738, 3000 DR, Rotterdam, The Netherlands.
  • ,
  • Peter J. van der Spek

      Affiliations

    • Bioinformatics, Erasmus Medical Center, Rotterdam, The Netherlands
  • ,
  • Clemens M.F. Dirven

      Affiliations

    • Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands
  • ,
  • Rob Willemsen

      Affiliations

    • CBG-Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
    • These authors contributed equally to this work.
  • ,
  • Johan M. Kros

      Affiliations

    • Departments of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    • These authors contributed equally to this work.

Received 24 May 2011; accepted 6 June 2011. published online 15 July 2011.

Research Highlights

► Zebrafish is an informative vertebrate model for human cardiovascular development. ► Glut1 is required to maintain the structural integrity of sinus venosus in vivo. ► The findings may have relevance to human embryogenesis of sinus venosus.

Keywords: Sinus venosus defect, Zebrafish model, Glut1 morphant

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PII: S0167-5273(11)00554-7

doi:10.1016/j.ijcard.2011.06.029

International Journal of Cardiology
Volume 154, Issue 3 , Pages e60-e61, 9 February 2012