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Abstract
In 24 consecutive patients with myocardial infarction, the concentrations of C-reactive
protein, α1-acid glycoprotein and α1-antichymotrypsin, as well as acid α1-glycoprotein and α1-antichymotrypsin glycosylation profiles were estimated. Blood samples were taken
at admission, after 4, 8, 12 and 24 h, on 2, 3, 6, 9, and 12 days of hospitalization.
All studied patients were divided into 2 groups: 12 patients without clinical or radiological
symptoms of acute heart failure and 12 patients with acute heart failure. The results
of all investigations were tested statistically to appraise significance of differences
between the two investigated groups. At admission, as well as after 6 and 12 h, C-reactive
protein concentration was significantly higher in patients who developed heart failure.
Similarly, the glycosylation profile of α1-antichymotrypsin, reported as reactivity coefficient, was of good prognostic value
from the first time-point on. Development of acute cardiac failure seemed to correlate
more with the magnitude of inflammatory reaction (measured by changes in acute phase
proteins) than with enzymatically estimated infarct size.
Keywords
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Article info
Publication history
Accepted:
February 24,
1995
Received:
December 31,
1994
Identification
Copyright
© 1995 Published by Elsevier Inc.