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Letter to the Editor| Volume 177, ISSUE 1, P8-10, November 15, 2014

Programmed death-1 (PD-1): A novel mechanism for understanding the acute immune deregulation in ST-segment elevation myocardial infarction

Published:September 27, 2014DOI:https://doi.org/10.1016/j.ijcard.2014.09.114
Programmed death-1 (PD-1): A novel mechanism for understanding the acute immune deregulation in ST-segment elevation myocardial infarction
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      Programmed death-1 (PD-1) is an activation marker of lymphocytes induced by antigen specific and non-specific stimulation that is overexpressed soon after the trigger onset in order to limit inflammation [
      • Agata Y.
      • Kawasaki A.
      • Nishimura H.
      • Ishida Y.
      • Tsubata T.
      • Yagita H.
      • et al.
      Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.
      Int Immunol. 1996; 8: 765-772
      ]. In turn this leads to a certain regulation of the adaptive immune response by inducing controlled death in massively activated lymphocytes [
      • Grabie N.
      • Gotsman I.
      • DaCosta R.
      • Pang H.
      • Stavrakis G.
      • Butte M.J.
      • et al.
      Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart.
      Circulation. 2007; 116: 2062-2071
      ]. Knowledge on the PD-1 in cardiovascular diseases is scarce and its dynamics in ST-segment elevation myocardial infarction (STEMI) is unknown.

      Keywords

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      References

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        • Kawasaki A.
        • Nishimura H.
        • Ishida Y.
        • Tsubata T.
        • Yagita H.
        • et al.
        Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.
        Int Immunol. 1996; 8: 765-772
        View in Article
        • Grabie N.
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        • et al.
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        View in Article
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      Article info

      Publication history

      Published online: September 27, 2014
      Accepted: September 21, 2014
      Received: September 11, 2014

      Identification

      DOI: https://doi.org/10.1016/j.ijcard.2014.09.114

      Copyright

      © 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.

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