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Letter to the Editor| Volume 177, ISSUE 1, P8-10, November 15, 2014

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Programmed death-1 (PD-1): A novel mechanism for understanding the acute immune deregulation in ST-segment elevation myocardial infarction

Published:September 27, 2014DOI:https://doi.org/10.1016/j.ijcard.2014.09.114
      Programmed death-1 (PD-1) is an activation marker of lymphocytes induced by antigen specific and non-specific stimulation that is overexpressed soon after the trigger onset in order to limit inflammation [
      • Agata Y.
      • Kawasaki A.
      • Nishimura H.
      • Ishida Y.
      • Tsubata T.
      • Yagita H.
      • et al.
      Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.
      ]. In turn this leads to a certain regulation of the adaptive immune response by inducing controlled death in massively activated lymphocytes [
      • Grabie N.
      • Gotsman I.
      • DaCosta R.
      • Pang H.
      • Stavrakis G.
      • Butte M.J.
      • et al.
      Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart.
      ]. Knowledge on the PD-1 in cardiovascular diseases is scarce and its dynamics in ST-segment elevation myocardial infarction (STEMI) is unknown.

      Keywords

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