Abstract
We performed HLA Class I and Class II typing in 16 patients (15 women, one man) with
a confirmed diagnosis of Takayasu arteritis. We did not find any of the previously
described associations with HLA-B52, and/or HLA-DRB1*1301 alleles. However, in our
patients, HLA-DRB1*1602 and HLA-DRB1*1001 were significantly increased. The association
of Takayasu arteritis with Amerindian and Asian HLA-DRB1 alleles (DRB1*1602 and DRB1*1001)
in the Colombian mestizo patients reported here, and with HLA-B*3906 previously reported
in Mexicans, suggest the possibility that some HLA and disease associations are markers
for ethnicity of a population carrying a disease gene which is present in an admixed
population with the disease.
Keywords
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References
- Takayasu’s arteritis.Curr Opin Rheumatol. 1994; 6: 32-38
- Takayasu arteritis.Ann Int Med. 1994; 120: 919-929
- Comprehensive analysis of HLA genes in Takayasu arteritis in Japan.Int J Cardiol. 1996; 54: S61-S69
- HLA-linked susceptibility and resistance to Takayasu arteritis.Heart Vessels. 1992; 7: 73-80
- HLA typing of Takayasu arteritis in Korea.Heart and Vessels. 1992; 7: 81-84
- Direct role of HLA-B5 in influencing susceptibility to Takayasu aortoarteritis.Int Journal Cardiol. 1996; 54: S71-S79
- A and B antigens in Takayasu’s arteritis.Rev Invest Clin. 1982; 34: 15-17
- HLA-DR6 (possible DRB1*1301) is associated with susceptibility to Takayasu arteritis in Mexicans.Heart and Vessels. 1996; 11: 277-280
- The American College of Rheumatology 1990 criteria for classifications of Takayasu arteritis.Arthritis Rheum. 1990; 33: 1129-1134
- Modification of an HLA-B PCR–SSOP typing system leading to improved allele discrimination.Tissue Antigens. 1995; 45: 232-236
- Development of PCR–SSOP for HLA-A typing for bone marrow registry donors.Tissue Antigens. 1997; 49: 61-66
- HLA-DR typing by PCR amplification with sequence specific primers (PCR–SSP) in 2 h; an alternative to serologic DR typing in clinical practice including donor–recipient matching in cadaveric transplantation.Tissue Antigens. 1992; 39: 225-231
- Complete allele typing of DR2-DRB1 by a combination of PCR–RFLP and PCR–SSP.Tissue Antigens. 1996; 47: 80-84
- The stimulation and significance of the logarithm of a ratio of frequencies.Am Hum Genet. 1956; 20: 309-311
- Angiographic findings of Takayasu arteritis: new classification.Int J Cardiol. 1996; 54: 103-110
- Natural history of aortoarteritis (Takayasu Disease).Circulation. 1989; 80: 429-437
- Demographic, clinical and angiographic data of patients with Takayasu arteritis in Brazil.Int J Cardiol. 1998; 66: S67-70
- Arteritis de Takayasu. Estudio de 11 casos.Rev MedChile. 1987; 115: 737-742
- Takayasu arteritis in Colombia.Int. J Cardiol. 1998; 66: S73-S79
- Vasculitis: Análisis de 12.683 protocolos de autopsia. Estudio de 34 casos.Rev Fac Med UN Col. 1996; 44: 75-80
- Anthropology report for region Latin-America: Amerindian and admixed populations.in: Charron D. Genetic diversity of HLA. vol. I. EDK Medical and Scientific International Publishers, 1997
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© 2000 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
