Abstract
Background: Hypertension is associated with changes in concentrations of vasoactive peptides
and procollagen propeptides, but their relationships with left ventricular hypertrophy
and cardiac function are unclear. Methods: We measured plasma levels of atrial natriuretic peptide (ANP), its amino terminal
propeptide (NT-proANP), B-type natriuretic peptide (BNP), endothelin-1 (ET-1), and
serum levels of the aminoterminal propeptide of type I procollagen (PINP) and the
aminoterminal propeptide of type III procollagen (PIIINP) and echocardiographic parameters
in 97 patients with hypertension in the Anglo-Scandinavian Cardiac Outcomes Trial.
Results: Median values (reference values) of the peptides were: ANP 11.2 (6.9–14.9) pmol/l,
NT-proANP 351 (143–311) pmol/l, BNP 1.1 (0.4–7.2) pmol/l, ET-1 8.7 (1.2–5.0) pmol/l,
PIIINP 2.8 (1.7–4.2) μg/l and PINP 29 (19–84) μg/l. Plasma BNP levels in patients
with left ventricular hypertrophy (1.2 pmol/l) and patients with echocardiographic
signs of diastolic dysfunction (1.5 pmol/l) were greater than those in patients without
hypertrophy (0.7 pmol/l) and normal diastolic parameters (0.9 pmol/l) (p<0.05). BNP was the only biochemical parameter that independently predicted interventricular
septal diastolic diameter (p<0.05), left ventricular mass index (p<0.01) and ratio of the velocity–time integrals of the E and A waves of the mitral
inflow in a stepwise logistic regression analysis (p<0.05). Conclusions: The results show that BNP reflects the remodelling process in hypertension.
Keywords
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Article info
Publication history
Accepted:
October 12,
2003
Received in revised form:
September 7,
2003
Received:
February 25,
2003
Identification
Copyright
© 2004 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
