Abstract
Background: Data concerning blood pressure changes, acutely induced by caffeine consumption,
are conflicting. Furthermore, limited data exist regarding central hemodynamic response
to caffeine ingestion by healthy young subjects. We investigated the acute effect
of coffee (80 mg of caffeine) and decaffeinated coffee on peripheral and central hemodynamics,
as well as on wave reflections. Subjects: For this purpose, 16 healthy volunteers (eight females and eight males, mean age
29±3.2 years) were investigated. Methods: Repeated measurements were performed at baseline and 30, 60, 90 and 120 min after
oral administration of each beverage in a double-blind crossover design. Aortic blood
pressures, augmentation index (AI) and pressure (AP) and timing of reflected waves
were evaluated by using applanation tonometry and pulse wave analysis. Results: Regular coffee increased central systolic (SBP) and diastolic pressure (DBP) from
96.2±9.9 to 101.1±10.1 mmHg, p=0.011 and from 72.6±9.4 to 76.5±9.0 mmHg, p=0.027, respectively, but no change was observed following consumption of decaffeinated
coffee. Peripheral systolic blood pressure did not change significantly after the
administration of either coffee. Augmentation index increased significantly following
regular coffee consumption. The change in AI was significantly higher following regular
compared to decaffeinated coffee consumption as shown by analysis of variance (ANOVA)
for repeated measures (p=0.001). Conclusions: These caffeine effects reveal an unfavourable effect on wave reflections and therefore
on left ventricular (LV) pulsatile afterload. It also revealed a significant acute
effect of caffeine consumption on central hemodynamics which is not observed at peripheral
pressures.
Keywords
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Article info
Publication history
Accepted:
November 23,
2003
Received in revised form:
November 22,
2003
Received:
July 17,
2003
Identification
Copyright
© 2004 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
