Abstract
Background and aim
Polymorphism in the p53 gene at codon 72 has been linked to the development of certain
diseases including cancer. A possible association between such polymorphism and the
development of coronary artery disease (CAD) and diabetes is being investigated, but
no conclusive evidence has been reached yet. Our study is the first pilot study to
be conducted on Kuwaitis suffering from CAD and diabetes, aiming at investigating
the possible existence of the above association.
Materials and methods
We analyzed the genotype distribution and allele frequency of p53 gene at codon 72
in 158 CAD samples and 110 controls, and in 142 diabetic and 130 controls.
Results
Analysis of CAD patients revealed an alarming significant association between the
disease and the existence of diabetes (P=0.0007). Also, the CAD patients had significantly higher level of triglyceride (P<0.0001) and cholesterol (P<0.0001) as compared to control. As for the polymorphism in p53 gene codon 72, we could
not detect any association with the genotype Pro/Pro, Pro/Arg or Arg/Arg distribution
(P=0.28) or allele (Pro or Arg) frequency (P=0.25) in the CAD patients. Similarly, no association was found with the genotype Pro/Pro,
Pro/Arg or Arg/Arg distribution (P=0.44) or allele (Pro or Arg) frequency (P=0.26) in the diabetic patients.
Conclusion
CAD seems to be strongly linked to diabetes in Kuwait. Polymorphism in the p53 gene
at codon 72 revealed no significant association with the development of CAD or diabetes
in Kuwait, which confirms other similar results obtained in the US and Asia.
Keywords
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Article info
Publication history
Published online: June 24, 2006
Accepted:
January 9,
2006
Received in revised form:
January 5,
2006
Received:
November 15,
2005
Identification
Copyright
© 2006 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
