Abstract
Background
Angiographically visible complex lesions which are associated with plaque vulnerability
have been shown to correlate strongly with clinical severity of unstable angina (UA).
By activating different immune/inflammatory cells or directly acting on the vessel
wall leptin has been shown to play a potential role in the development of acute coronary
syndrome. However, the relationship between leptin and simple or complex lesion morphology
in UA has not been investigated. Therefore, we designed this study to determine the
association between plasma leptin level and simple or complex lesions in patients
with UA and to see any correlation between leptin and other inflammatory markers in
these patients.
Methods
Plasma concentrations of leptin, interleukin (IL)-6, IL-10 and high-sensitivity C-Reactive
Protein (hsCRP) were analyzed in 47 patients with UA. These patients were also angiographically
studied and divided into two groups: simple lesion (n=18) and complex lesion (n=29) based on the coronary plaque morphology. We further compared them with 20 control
subjects having no evidence of coronary artery diseases.
Results
Plasma leptin concentrations were higher in patients having complex lesions compared
to those having simple lesions as well as normal controls. Similarly IL-6 and hsCRP
were also higher in complex lesion group compared to simple lesion group and controls,
and leptin was positively correlated with IL-6 and hsCRP. Concentrations of IL-10
were lower in simple and complex lesion groups compared to the controls and leptin
was negatively correlated with IL-10, but no significant difference between simple
and complex lesions was found. Furthermore, leptin was found to be an independent
predictor for the complex lesion morphology in UA patients.
Conclusion
These findings suggested that angiographically visible complex lesions are associated
with increased concentrations of leptin, and thus leptin can be a useful biomarker
for risk stratification in UA.
Keywords
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Article info
Publication history
Published online: May 10, 2007
Accepted:
March 30,
2007
Received in revised form:
February 19,
2007
Received:
October 15,
2006
Identification
Copyright
© 2007 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
