Advertisement

Ginger (Zingiber officinale Roscoe): A hot remedy for cardiovascular disease?

Published:November 26, 2007DOI:https://doi.org/10.1016/j.ijcard.2007.07.107

      Abstract

      Ginger is now exciting considerable interest for its potential to treat many aspects of cardiovascular disease. This letter reviews the more recent trials, which suggest that ginger shows considerable anti-inflammatory, antioxidant, anti-platelet, hypotensive and hypolipidemic effect in in vitro and animal studies. Human trials have been few and generally used a low dose with inconclusive results, however dosages of 5 g or more demonstrated significant anti-platelet activity. More human trials are needed using an appropriate dosage of a standardised extract. Should these prove positive, ginger has the potential to offer not only a cheaper natural alternative to conventional agents but one with significantly lower side effects.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to International Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

      1. Physicians desk reference for herbal medicines. Thomson, Montvale, New Jersey, USA2004
        • Jiang X.
        • Blair E.Y.
        • McLachlan A.J.
        Investigation of the effects of herbal medicines on warfarin response in healthy subjects: a population pharmacokinetic–pharmacodynamic modelling approach.
        J Clin Pharmacol. 2006; 46: 1370-1378
        • Bordia A.
        • Verma S.K.
        • Srivastava K.C.
        Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease.
        Prostaglandins Leukot Essent Fat Acids. 1997; 56: 379-384
        • Schwertner H.A.
        • Rios D.C.
        • Pascoe J.E.
        Variation in concentration and labelling of ginger root dietary supplements.
        Obstet Gynecol. 2006; 107: 1337-1343
        • Srivastava K.C.
        • Mustafa T.
        Ginger (Zingiber officinale) and rheumatic disorders.
        Med Hypoth. 1989; 29: 25-28
        • Grzanna R.
        • Lindmark L.
        • Frondoza C.G.
        Ginger — an herbal medicinal product with broad anti-inflammatory actions.
        J Med Food. 2005; 8: 125-132
        • Young H.Y.
        • Luo Y.L.
        • Cheng H.Y.
        • Hsieh W.C.
        • Liao J.C.
        • Peng W.H.
        Analgesic and anti-inflammatory activities of [6]-gingerol.
        J Ethnopharmacol. 2005; 96: 207-210
        • Thomson M.
        • al-Qattan K.
        • al-Sawan S.
        • Alnaqeeb M.
        • Khan I.
        • Ali M.
        The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent.
        Prostaglandins Leukot Essent Fat Acids. 2002; 67: 475-478
        • Srivastava K.C.
        • Mustafa T.
        Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders.
        Med Hypothesis. 1992; 39: 342-348
        • Bliddal H.
        • Rosetzsky A.
        • Schlichting P.
        • et al.
        A randomised, placebo-controlled, cross-over study of ginger extracts and Ibuprofen in osteoarthritis.
        O steoarthr Cartil. 2000; 8: 9-12
        • Ahmed R.S.
        • Seth V.
        • Banerjee B.D.
        Influence of dietary ginger (Zingiber officinales Rosc) on antioxidant defense system in rat: comparison with ascorbic acid.
        Indian J Exp Biol. 2000; 38: 604-606
        • Fuhrman B.
        • Rosenblat M.
        • Hayek T.
        • Coleman R.
        • Aviram M.
        Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-deficient mice.
        J Nutr. 2000; 130: 1124-1231
        • Verma S.K.
        • Singh M.
        • Jain P.
        • Bordia A.
        Protective effect of ginger, Zingiber officinale Rosc on experimental atherosclerosis in rabbits.
        Indian J Exp Biol. 2004; 42: 736-738
        • Koo K.
        • Ammit A.
        • Tran V.
        • Duke C.
        • Roufogalis B.
        Gingerols and related analogues inhibit arachidonic acid-induced human platelet serotonin release and aggregation.
        Thromb Res. 2001; 103: 387-397
        • Nurtjahja-Tjendraputra E.
        • Ammit A.
        • Roufogalis B.
        • Tran V.
        • Duke C.
        Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger.
        Thromb Res. 2003; 111: 259-265
        • Ghayur M.N.
        • Gilani A.H.
        Ginger lowers blood pressure through blockade of voltage-dependent calcium channels.
        Cardiovasc Pharmacol. 2005; 45: 74-80
        • Suekawa M.
        • Aburada M.
        • Hosoya E.
        Pharmacological studies on ginger. II. Pressor action of [6]-shogaol in anaesthetised rats or hindquarters, tail and mesenteric vascular beds of rats.
        J Pharmacobio-Dyn. 1986; 9: 842-852
        • Young H.Y.
        • Liao J.C.
        • Chang Y.S.
        • Luo Y.L.
        • Lu M.C.
        • Peng W.H.
        Synergistic effect of ginger and nifedipine on human platelet aggregation: a study in hypertensive patients and normal volunteers.
        Am J Chin Med. 2006; 34: 545-551
        • Kobayshi M.
        • Ishida Y.
        • Shoji N.
        • Ohizumi Y.
        Cardiotonic action of [8]-gingerol, an activator of the Ca++-pumping adenosine triphosphatase of sarcoplasmic reticulum in Guinea pig atrial muscle.
        J Pharmacol Exp Ther. 1988; 246: 667-673
        • Iwasaki Y.
        • Morita A.
        • Iwasawa T.
        • et al.
        A nonpungent component of steamed ginger – [10]-shogaol – increases adrenaline secretion via the activation of TRPV1.
        Nutr Neurosci. 2006; 9: 169-176