Patients with advanced heart failure are exercise intolerant. Low cellular energy levels in the failing heart have been proposed. Energy enhancing substrates have revealed mixed results. Ribose, a pentose monosaccharide, has shown to replenish low myocardial energy levels, improving cardiac dysfunction following ischemia, and improving ventilation efficiency in patients with heart failure. As current pharmaceuticals do not address cellular energy levels, this study was designed to investigate the role of ribose on ventilation at anaerobic threshold in congestive heart failure patients. d-ribose (5gms/dose, tid) was assessed in 16 NYHA class III–IV, heart failure patients with VO2, tidal volume/VCO2, heart rate/tidal volume evaluated at 8 weeks. All patients had a significant improvement in ventilatory parameters at anaerobic threshold, along with a 44% Weber class improvement. Ribose improved the ventilatory exercise status in advanced heart failure patients.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to International Journal of Cardiology
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Peak VO2 and VE/CO2 slope in patients with heart failure. A prognostic comparison.Am Heart J. 2004; 147: 354-360
- Cardiopulmonary exercise testing in the clinical and prognosis assessment of diastolic heart failure.JACC. 2005; 46: 1883-1890
- Is the failing heart energy starved? On using chemical energy to support cardiac function.Circ Res. 2004; 95: 135-145
- Recovery of ATP and return of function after global ischemia.Circ (Part II). 1985; 72: III-298
- Ribose accelerates the repletion of the ATP pool during recovery from reversible ischemia of the rat myocardium.J Mol Cell Cardiol. 1984; 16: 863-866
- d-ribose improves diastolic dysfunction and quality of life in congestive heart failure patients: a prospective feasibility study.Eur J Heart Fail. 2003; 5: 615-619
- d-ribose benefits low level exercise in advanced class heart failure patients.J Card Fail. 2006; 12: S122
- Ventilatory response to exercise correlates with impaired heart rate variability in patients with chronic congestive heart failure.Am J Cardiol. 1998; 82: 338-344
Published online: August 01, 2008
Accepted: May 3, 2008
Received: January 23, 2008
© 2008 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.