Abstract
Patients with advanced heart failure are exercise intolerant. Low cellular energy
levels in the failing heart have been proposed. Energy enhancing substrates have revealed
mixed results. Ribose, a pentose monosaccharide, has shown to replenish low myocardial
energy levels, improving cardiac dysfunction following ischemia, and improving ventilation
efficiency in patients with heart failure. As current pharmaceuticals do not address
cellular energy levels, this study was designed to investigate the role of ribose
on ventilation at anaerobic threshold in congestive heart failure patients. d-ribose (5gms/dose, tid) was assessed in 16 NYHA class III–IV, heart failure patients
with VO2, tidal volume/VCO2, heart rate/tidal volume evaluated at 8 weeks. All patients had a significant improvement
in ventilatory parameters at anaerobic threshold, along with a 44% Weber class improvement.
Ribose improved the ventilatory exercise status in advanced heart failure patients.
Keywords
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Article info
Publication history
Published online: August 01, 2008
Accepted:
May 3,
2008
Received:
January 23,
2008
Identification
Copyright
© 2008 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
