Abstract
Background
A large amount of cohort studies addressed coffee consumption and risk of coronary
heart disease (CHD) and yielded inconsistent results. We conducted a meta-analysis
to estimate the pooling effects.
Methods
We searched for all published English articles indexed in MEDLINE or PubMed from January
1966 to January 2008. Twenty-one independent prospective cohort studies, which tested
CHD risk by coffee consumption, were identified. A general variance-based method was
used to pool the relative risks (RR). 15,599 cases from 407,806 participants were
included in pooling the overall effects.
Results
As compared to the light coffee consumption (<1 cup/d in US or ≤2 cups/d in Europe), under the random-effects model, the pooled CHD RRs (95% CI) for
all studies combined were 0.96 (0.87–1.06), 1.04 (0.92–1.17) and 1.07 (0.87–1.32)
for the moderate (1–3 or 3–4 cups/d), heavy (4–5 or 5–6 cups/d) and very heavy (≥6 or ≥7 cups/d) categories of coffee consumption (all p>0.05); Moderate coffee consumption showed significantly lower CHD RR (95% CI) of 0.82
(0.73–0.92) (p<0.001) in women, and of 0.87 (0.80–0.86) (p=0.001) in men and women followed ≤10 years.
Conclusion
Our findings do not support the hypothesis that coffee consumption increases the long-term
risk of coronary heart disease. Habitual moderate coffee drinking was associated with
a lower risk of CHD in women.
Keywords
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Article info
Publication history
Published online: August 19, 2008
Accepted:
June 28,
2008
Received in revised form:
March 23,
2008
Received:
November 23,
2007
Footnotes
☆This study was supported by the 5010 Program for Clinical Researches by Sun Yat-sen University, Guangzhou, PR China.
Identification
Copyright
© 2008 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
