Letter to the Editor| Volume 143, ISSUE 3, P431-432, September 03, 2010

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Increased beat-to-beat ‘R’ amplitude variability in patients with panic disorder

Published:December 22, 2008DOI:


      In patients with panic disorder, an anxiety disorder, isoproterenol increases beat-to-beat QRS amplitude variability much more than in normal controls. In this pilot study, we found that patients with panic disorder had significantly higher beat-to-beat QRS amplitude variability compared to controls in resting supine and standing postures. This may be partly due to myocardial electrical instability or irregular respiration in this patient group. These findings are important in view of the association between panic disorder and increased cardiovascular mortality.


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