In patients with panic disorder, an anxiety disorder, isoproterenol increases beat-to-beat QRS amplitude variability much more than in normal controls. In this pilot study, we found that patients with panic disorder had significantly higher beat-to-beat QRS amplitude variability compared to controls in resting supine and standing postures. This may be partly due to myocardial electrical instability or irregular respiration in this patient group. These findings are important in view of the association between panic disorder and increased cardiovascular mortality.
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Published online: December 22, 2008
Accepted: December 3, 2008
Received in revised form: November 30, 2008
Received: July 8, 2008
© 2008 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.