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Letter to the Editor| Volume 150, ISSUE 2, P210-211, July 15, 2011

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Mast cell activation disorders presenting with cerebral vasospasm-related symptoms: A “Kounis-like” syndrome?

Published:June 03, 2011DOI:https://doi.org/10.1016/j.ijcard.2011.05.007
Mast cell activation disorders presenting with cerebral vasospasm-related symptoms: A “Kounis-like” syndrome?
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      Kounis syndrome is characterized by acute coronary events occurring throughout anaphylactic or anaphylactoid reactions, even in patients with normal coronary arteries. Clinical manifestations of this syndrome have been attributed to coronary artery spasm or plaque erosion or rupture induced by acute inflammatory mediators release during these reactions [
      • Kounis N.G.
      Kounis syndrome (allergic angina and allergic myocardial infarction): a natural paradigm?.
      Int J Cardiol. 2006; 110: 7-14
      ,
      • Cevik C.
      • Nugent K.
      • Shome G.P.
      • Kounis N.G.
      Treatment of Kounis syndrome.
      Int J Cardiol. 2010; 143: 223-226
      ,
      • Morel O.
      • Jesel L.
      • Morel N.
      • Nguyen A.
      • Trinh A.
      • Ohlmann P.
      • Imperiale A.
      Transient left ventricular dysfunction syndrome during anaphylactic shock: vasospasm, Kounis syndrome or epinephrine-induced stunned myocardium?.
      Int J Cardiol. 2010; 145: 501-503
      ,
      • Biteker M.
      A new classification of Kounis syndrome.
      Int J Cardiol. 2010; 145: 553
      ]. Similarly, vasospasm-related symptoms involving organs other than the heart might also occur in patients with conditions characterized by acute mast cells (MC)-mediator release, as in systemic mastocytosis (SM) and MC activation disorders (MCAD). We report two patients with MC-related disorders who developed transient ischemic attacks while they had previous history of chest pain and Kounis syndrome.

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      References

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        Kounis syndrome (allergic angina and allergic myocardial infarction): a natural paradigm?.
        Int J Cardiol. 2006; 110: 7-14
        View in Article
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        Treatment of Kounis syndrome.
        Int J Cardiol. 2010; 143: 223-226
        View in Article
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        • Morel N.
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        Transient left ventricular dysfunction syndrome during anaphylactic shock: vasospasm, Kounis syndrome or epinephrine-induced stunned myocardium?.
        Int J Cardiol. 2010; 145: 501-503
        View in Article
        • Biteker M.
        A new classification of Kounis syndrome.
        Int J Cardiol. 2010; 145: 553
        View in Article
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      Article info

      Publication history

      Published online: June 03, 2011
      Accepted: May 13, 2011
      Received: April 16, 2011

      Identification

      DOI: https://doi.org/10.1016/j.ijcard.2011.05.007

      Copyright

      © 2011 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.

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