Abstract
Background
Selenium and coenzyme Q10 are essential for the cell. Low cardiac contents of selenium
and coenzyme Q10 have been shown in patients with cardiomyopathy, but inconsistent
results are published on the effect of supplementation of the two components separately.
A vital relationship exists between the two substances to obtain optimal function
of the cell. However, reports on combined supplements are lacking.
Methods
A 5-year prospective randomized double-blind placebo-controlled trial among Swedish
citizens aged 70 to 88 was performed in 443 participants given combined supplementation
of selenium and coenzyme Q10 or a placebo. Clinical examinations, echocardiography
and biomarker measurements were performed. Participants were monitored every 6th month
throughout the intervention.
The cardiac biomarker N-terminal proBNP (NT-proBNP) and echocardiographic changes
were monitored and mortalities were registered. End-points of mortality were evaluated
by Kaplan–Meier plots and Cox proportional hazard ratios were adjusted for potential
confounding factors. Intention-to-treat and per-protocol analyses were applied.
Results
During a follow up time of 5.2 years a significant reduction of cardiovascular mortality was found in the active
treatment group vs. the placebo group (5.9% vs. 12.6%; P=0.015). NT-proBNP levels were significantly lower in the active group compared with
the placebo group (mean values: 214 ng/L vs. 302 ng/L at 48 months; P=0.014). In echocardiography a significant better cardiac function score was found
in the active supplementation compared to the placebo group (P=0.03).
Conclusion
Long-term supplementation of selenium/coenzyme Q10 reduces cardiovascular mortality.
The positive effects could also be seen in NT-proBNP levels and on echocardiography.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to International Journal of CardiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- The importance of selenium to human health.Lancet. 2000; 356: 233-241
- Selenium and the selenoprotein thioredoxin reductase in the prevention, treatment and diagnostics of cancer.Antioxid Redox Signal. 2010; 12: 867-880
- Selenium in human health and disease.Antioxid Redox Signal. 2011; 14: 1337-1383
- Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.PLoS One. 2011; 6: e14771
- Selenium in cancer prevention: a review of the evidence and mechanism of action.Proc Nutr Soc. 2005; 64: 527-542
- The effect of selenium-fortified table salt in the prevention of Keshan disease on a population of 1.05 million.Biomed Environ Sci. 1990; 3: 422-428
- Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group.JAMA. 1996; 276: 1957-1963
- Serum selenium and peripheral arterial disease: results from the national health and nutrition examination survey, 2003–2004.Am J Epidemiol. 2009; 169: 996-1003
- The association of low selenium and renal insufficiency with coronary heart disease and all-cause mortality: NHANES III follow-up study.Atherosclerosis. 2010; 212: 689-694
- Effects of selenium supplementation on cardiovascular disease incidence and mortality: secondary analyses in a randomized clinical trial.Am J Epidemiol. 2006; 163: 694-699
- Association between cardiovascular death and myocardial infarction and serum selenium in a matched-pair longitudinal study.Lancet. 1982; 2: 175-179
- Myocardial ischemia–reperfusion injury, antioxidant enzyme systems, and selenium: a review.Curr Med Chem. 2007; 14: 1539-1549
- Selenoproteins, cholesterol-lowering drugs, and the consequences: revisiting of the mevalonate pathway.Trends Cardiovasc Med. 2004; 14: 273-281
- Age-related changes in the lipid compositions of rat and human tissues.Lipids. 1989; 24: 579-584
- Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10.Proc Natl Acad Sci U S A. 1985; 82: 901-904
- Coenzyme Q10 and high-sensitivity C-reactive protein in ischemic and idiopathic dilated cardiomyopathy.Clin Chem Lab Med. 2008; 46: 382-386
- Coenzyme Q10: an independent predictor of mortality in chronic heart failure.J Am Coll Cardiol. 2008; 52: 1435-1441
- The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure.Eur Heart J. 2005; 26: 2238-2244
- The impact of coenzyme Q10 on systolic function in patients with chronic heart failure.J Card Fail. 2006; 12: 464-472
- Coenzyme Q10 as an adjunctive therapy in patients with congestive heart failure.J Am Coll Cardiol. 2000; 36: 304-305
- Selenium and antioxidant defenses as major mediators in the development of chronic heart failure.Heart Fail Rev. 2006; 11: 13-17
- Comparison of different echocardiographic methods with radionuclide imaging for measuring left ventricular ejection fraction during acute myocardial infarction treated by thrombolytic therapy.Am J Cardiol. 1998; 81: 538-544
- Comparison and reproducibility of visual echocardiographic and quantitative radionuclide left ventricular ejection fractions.Am J Cardiol. 1996; 77: 843-850
- Selenium speciation and isotope composition in 77Se-enriched yeast using gradient elution HPLC separation and ICP-dynamic reaction cell-MS.J Anal At Spectrom. 2003; 18: 310-316
- Speciation and bioavailability of selenium in yeast-based intervention agents used in cancer chemoprevention studies.J AOAC Int. 2004; 87: 225-232
- Absorption, excretion, and retention of selenium from a high selenium yeast in men with a high intake of selenium.Food Nutr Res. 2008; 52
- Bioavailability of four oral coenzyme Q10 formulations in healthy volunteers.Mol Aspects Med. 1994; 15 ([Suppl.]): s273-s280
- A one year bioavailability study of coenzyme Q10 with 3 months withdrawal period.Mol Aspects Med. 1994; 15 ([Suppl.]): s281-s285
- The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress.J Biol Chem. 2003; 278: 2141-2146
- Coenzyme Q10 and antioxidants in acute myocardial infarction.Mol Aspects Med. 1994; 15 ([Suppl.]): s143-s147
- Coenzyme Q10 terclatrate and creatine in chronic heart failure: a randomized, placebo-controlled, double-blind study.Clin Cardiol. 2011; 34: 211-217
- Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study.Atherosclerosis. 2010; 209: 271-277
- Effect of dietary selenium on the progression of heart failure in the ageing spontaneously hypertensive rat.Mol Nutr Food Res. Oct 2010; 54: 1436-1444
- Elevated circulating levels of thioredoxin and stress in chronic heart failure.Eur J Heart Fail. 2004; 6: 883-890
Article info
Publication history
Published online: May 25, 2012
Accepted:
April 28,
2012
Received in revised form:
April 17,
2012
Received:
January 10,
2012
Footnotes
☆This study was registered at Clinicaltrials.gov, and has the identifier NCT01443780.
Identification
Copyright
© 2012 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
