Abstract
Background
Selenium and coenzyme Q10 are essential for the cell. Low cardiac contents of selenium
and coenzyme Q10 have been shown in patients with cardiomyopathy, but inconsistent
results are published on the effect of supplementation of the two components separately.
A vital relationship exists between the two substances to obtain optimal function
of the cell. However, reports on combined supplements are lacking.
Methods
A 5-year prospective randomized double-blind placebo-controlled trial among Swedish
citizens aged 70 to 88 was performed in 443 participants given combined supplementation
of selenium and coenzyme Q10 or a placebo. Clinical examinations, echocardiography
and biomarker measurements were performed. Participants were monitored every 6th month
throughout the intervention.
The cardiac biomarker N-terminal proBNP (NT-proBNP) and echocardiographic changes
were monitored and mortalities were registered. End-points of mortality were evaluated
by Kaplan–Meier plots and Cox proportional hazard ratios were adjusted for potential
confounding factors. Intention-to-treat and per-protocol analyses were applied.
Results
During a follow up time of 5.2 years a significant reduction of cardiovascular mortality was found in the active
treatment group vs. the placebo group (5.9% vs. 12.6%; P=0.015). NT-proBNP levels were significantly lower in the active group compared with
the placebo group (mean values: 214 ng/L vs. 302 ng/L at 48 months; P=0.014). In echocardiography a significant better cardiac function score was found
in the active supplementation compared to the placebo group (P=0.03).
Conclusion
Long-term supplementation of selenium/coenzyme Q10 reduces cardiovascular mortality.
The positive effects could also be seen in NT-proBNP levels and on echocardiography.
Keywords
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Article info
Publication history
Published online: May 25, 2012
Accepted:
April 28,
2012
Received in revised form:
April 17,
2012
Received:
January 10,
2012
Footnotes
☆This study was registered at Clinicaltrials.gov, and has the identifier NCT01443780.
Identification
Copyright
© 2012 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.