Erythropoietin (EPO) is a hematopoietic cytokine which also enhances the mobilization
of endothelial progenitor cells (EPCs) [
[1]
] and exerts a protective effect on endothelial cells in several vascular injury models
[
[2]
]. In addition, neovascularization plays a role in diseases involving ischemia, including
tumors, atherosclerotic plaques, and ischemic heart disease [
[3]
]. The angiopoietin (Ang)/Tie system has been reported to be critically involved in
disease progression through the activation of signaling pathways that control angiogenic
remodeling [
[4]
]. Although Ang-1 and Ang-2 share similar binding affinities for the Tie2 receptor
(the tyrosine kinase with immunoglobulin and epidermal growth factor [EGF] homology
domain 2 receptor), they have opposing effects on receptor activation. Ang-1 induces
receptor phosphorylation and contributes to blood vessel stabilization by the recruitment
of periendothelial cells [
[5]
]. Therefore, we sought to investigate the effects of erythropoietin administration
on perfusion, neovascularization and angiogenic factors' expression in an experimental
model of limb ischemia. More specifically, we aimed to assess its effects on blood
flow and vascular endothelial growth factor (VEGF), Ang-2/Tie-2 expression in the
ischemic limb.Keywords
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References
- Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization.Blood. 2003; 102: 1340-1346
- Influence of mechanical, cellular, and molecular factors on collateral artery growth.Circ Res. 2004; 95: 449-458
- Angiogenesis in health and disease.Nat Med. 2003; 9: 653-660
- Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation.Nature. 1995; 376: 70-74
- Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.Cell. 1996; 87: 1161-1169
Article info
Publication history
Published online: September 10, 2012
Accepted:
August 21,
2012
Received in revised form:
June 26,
2012
Received:
May 23,
2012
Identification
Copyright
© 2012 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
