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Does alpha-lipoic acid treatment play a role on oxidative stress and insulin resistance in overweight/obese patients?

Published:November 30, 2012DOI:https://doi.org/10.1016/j.ijcard.2012.11.107
      With great interest, we read the recent manuscript by Yan et al. [
      • Yan W.
      • Li N.
      • Hu X.
      • et al.
      Effect of oral ALA supplementation on oxidative stress and insulin sensitivity among overweight/obese adults: a double-blinded, randomized, controlled, cross-over intervention trial.
      ] regarding the beneficial effects of alpha-lipoic acid (ALA) treatment on oxidative stress and insulin resistance in overweight/obese patients. The authors have performed a double-blinded, randomized, cross-over trial to investigate whether oral ALA administration will lower the risk of cardiovascular disease by decreasing the level of oxidative stress markers including “oxidized LDL” and “8-Iso Prostaglandin F2 alpha” or improving insulin sensitivity analyzing HOMA-IR levels. The markers have been analyzed from 103 patients without cardiovascular disease, hypertension, diabetes, or any other inflammatory diseases [Group 1 (n=51) had received 8-week placebo followed by oral ALA intervention (1200 mg/day) for 8-week, while Group 2 (n=52) had received 8-week ALA followed by placebo for 8-week, with a wash-out of 4 weeks]. Authors have very clearly performed their study and discussed the results. In our opinion, however, some points of this work are not sufficiently clear.

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