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Rapid Communication| Volume 171, ISSUE 2, P299-301, February 01, 2014

Mediterranean diet and heart rate: The PREDIMED randomised trial

  • M. García-López
    Affiliations
    Department of Cardiology, Clinic University of Navarra, Pamplona, Spain

    Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
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  • E. Toledo
    Affiliations
    Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain

    CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain
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  • J.J. Beunza
    Affiliations
    Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain

    CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain
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  • F. Aros
    Affiliations
    CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain

    Department of Cardiology, University Hospital of Alava, Vitoria, Spain
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  • R. Estruch
    Affiliations
    CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain

    Department of Internal Medicine, Institut d'Investigacions Biomèdiques Augusti Pi Sunyer (IDIBAPS), Hospital Clinic, Barcelona, Spain
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  • J. Salas-Salvadó
    Affiliations
    CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain

    Human Nutrition Unit, Biochemistry and Biotechnology Department, Hospital Universitari de Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, Reus, Spain
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  • D. Corella
    Affiliations
    CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain

    Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain
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  • E. Ros
    Affiliations
    CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain

    Lipid Clinic, Endocrinology and Nutrition Service, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, Barcelona, Spain
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  • M.I. Covas
    Affiliations
    CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain

    Cardiovascular Epidemiology Unit, Municipal Institut for Medical Research (IMIM), Barcelona, Spain
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  • E. Gómez-Gracia
    Affiliations
    Department of Preventive Medicine, School of Medicine, University of Malaga, Málaga, Spain
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  • M. Fiol
    Affiliations
    CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain

    University Institute for Health Sciences Investigation, Hospital Son Espases, Palma de Mallorca, Spain
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  • R.M. Lamuela-Raventós
    Affiliations
    CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain

    Nutrition and Food Science Department, CaRTA, INSA Pharmacy School, University of Barcelona, Spain
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  • J. Lapetra
    Affiliations
    CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain

    Department of Family Medicine, Primary Care Division of Sevilla, San Pablo Health Center, Sevilla, Spain
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  • P. Buil-Cosiales
    Affiliations
    Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain

    CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain

    Servicio Navarro de Salud, Osasunbidea, Pamplona, Spain
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  • S. Carlos
    Affiliations
    Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
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  • L. Serra-Majem
    Affiliations
    CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain

    Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Spain
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  • X. Pintó
    Affiliations
    CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain

    Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Spain
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  • V. Ruiz-Gutiérrez
    Affiliations
    CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain

    Instituto de la Grasa, Consejo Superior de Investigaciones Cientificas, Sevilla, Spain
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  • M.A. Martínez-González
    Correspondence
    Corresponding author at: Department of Preventive Medicine and Public Health, University of Navarra, CP. 31008, Pamplona, Spain. Tel.: +34 948 425 600; fax: +34 948 425 740.
    Affiliations
    Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain

    CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain
    Search for articles by this author
Published:December 26, 2013DOI:https://doi.org/10.1016/j.ijcard.2013.11.074
      A higher heart rate (HR) has been associated with increased total and cardiovascular mortality [
      • Greenland P.
      • Daviglus M.L.
      • Dyer A.R.
      • et al.
      Resting heart rate is a risk factor for cardiovascular and noncardiovascular mortality: the Chicago Heart Association Detection Project in Industry.
      ,
      • Jensen M.T.
      • Marott J.L.
      • Jensen G.B.
      Elevated resting heart rate is associated with greater risk of cardiovascular and all-cause mortality in current and former smokers.
      ]. Clinical trials support the beneficial effect of decreasing HR in patients with heart failure [
      • Fox K.
      • Ford I.
      • Steg P.G.
      • Tendera M.
      • Ferrari R.
      Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial.
      ] and ischaemic heart disease [
      • Ekman I.
      • Chassany O.
      • Komajda M.
      • et al.
      Heart rate reduction with ivabradine and health related quality of life in patients with chronic heart failure: results from the SHIFT study.
      ]. A recent cross-sectional study showed that closer adherence to the Mediterranean diet (MeDiet) was related to lower HR [
      • García-López M.
      • Martinez-Gonzalez M.A.
      • Basterra-Gortari F.J.
      • Barrio-López M.T.
      • Gea A.
      • Beunza J.J.
      Adherence to the Mediterranean dietary pattern and heart rate in the SUN project.
      ]. We evaluated the association between adherence to the MeDiet (measured with a score from 0 to 14 obtained by a validated screener [
      • Schröder H.
      • Fitó M.
      • Estruch R.
      • et al.
      A short screener is valid for assessing Mediterranean diet adherence among older Spanish men and women.
      ]) and HR using both a cross-sectional and a longitudinal analysis of the PREDIMED trial [
      • Estruch R.
      • Ros E.
      • Salas-Salvado J.
      • et al.
      Primary prevention of cardiovascular disease with a Mediterranean diet.
      ,
      • Martínez-González M.Á.
      • Corella D.
      • Salas-Salvadó J.
      • et al.
      Cohort profile: design and methods of the PREDIMED study.
      ].

      Keywords

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      References

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        • Daviglus M.L.
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        • et al.
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        Heart rate reduction with ivabradine and health related quality of life in patients with chronic heart failure: results from the SHIFT study.
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