Advertisement
Letter to the Editor| Volume 177, ISSUE 1, P8-10, November 15, 2014

Download started.

Ok

Programmed death-1 (PD-1): A novel mechanism for understanding the acute immune deregulation in ST-segment elevation myocardial infarction

Published:September 27, 2014DOI:https://doi.org/10.1016/j.ijcard.2014.09.114
Programmed death-1 (PD-1): A novel mechanism for understanding the acute immune deregulation in ST-segment elevation myocardial infarction
Previous ArticleRole of hypocalcemia in identification of 22q11 deletion syndrome among patients with congenital heart defects
Next ArticleLong-term prognostic value of late gadolinium enhancement in a cohort of patients with nonischemic dilated cardiomyopathy
      Programmed death-1 (PD-1) is an activation marker of lymphocytes induced by antigen specific and non-specific stimulation that is overexpressed soon after the trigger onset in order to limit inflammation [
      • Agata Y.
      • Kawasaki A.
      • Nishimura H.
      • Ishida Y.
      • Tsubata T.
      • Yagita H.
      • et al.
      Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.
      Int Immunol. 1996; 8: 765-772
      ]. In turn this leads to a certain regulation of the adaptive immune response by inducing controlled death in massively activated lymphocytes [
      • Grabie N.
      • Gotsman I.
      • DaCosta R.
      • Pang H.
      • Stavrakis G.
      • Butte M.J.
      • et al.
      Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart.
      Circulation. 2007; 116: 2062-2071
      ]. Knowledge on the PD-1 in cardiovascular diseases is scarce and its dynamics in ST-segment elevation myocardial infarction (STEMI) is unknown.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to International Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Agata Y.
        • Kawasaki A.
        • Nishimura H.
        • Ishida Y.
        • Tsubata T.
        • Yagita H.
        • et al.
        Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.
        Int Immunol. 1996; 8: 765-772
        View in Article
        • Grabie N.
        • Gotsman I.
        • DaCosta R.
        • Pang H.
        • Stavrakis G.
        • Butte M.J.
        • et al.
        Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart.
        Circulation. 2007; 116: 2062-2071
        View in Article
        • Bodi V.
        • Sanchis J.
        • Lopez-Lereu M.P.
        • Losada A.
        • Nunez J.
        • Pellicer M.
        • et al.
        Usefulness of a comprehensive cardiovascular magnetic resonance imaging assessment for predicting recovery of left ventricular wall motion in the setting of myocardial stunning.
        J Am Coll Cardiol. 2005; 46: 1747-1752
        View in Article
        • Bodi V.
        • Sanchis J.
        • Mainar L.
        • Chorro F.J.
        • Nunez J.
        • Monmeneu J.V.
        • et al.
        Right ventricular involvement in anterior myocardial infarction: a translational approach.
        Cardiovasc Res. Sep 1 2010; 87: 601-608
        View in Article
        • Chen G.Y.
        • Nunez G.
        Sterile inflammation: sensing and reacting to damage.
        Nat Rev Immunol. 2010; 10: 826-837
        View in Article
        • Gianchecchi E.
        • Delfino D.V.
        • Fierabracci A.
        Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity.
        Autoimmun Rev. 2013; 12: 1091-1100
        View in Article

      Article info

      Publication history

      Published online: September 27, 2014
      Accepted: September 21, 2014
      Received: September 11, 2014

      Identification

      DOI: https://doi.org/10.1016/j.ijcard.2014.09.114

      Copyright

      © 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX