The high prevalence of both non-aspirin NSAID use and atrial fibrillation makes an association between these two variables of considerable clinical and public-health importance. Previously, only two studies had examined the effect of selective COX-2 inhibitors on the risk of atrial fibrillation [
- Bäck M.
- Yin L.
- Ingelsson E.
Cyclooxygenase-2 inhibitors and cardiovascular risk in a nation-wide cohort study after the withdrawal of rofecoxib.
Eur Heart J. 2012; 33: 1928-1933
2]. Therefore we read with great interest the study by Chao et al. [
- Schmidt M.
- Christiansen C.F.
- Mehnert F.
- Rothman K.J.
- Sørensen H.T.
Non-steroidal anti-inflammatory drug use and risk of atrial fibrillation or flutter: population based case-control study.
BMJ. 2011; 343: d3450
], which concluded “new NSAID use may predispose patients to atrial fibrillation but use of selective COX-2 inhibitors was not significantly related to atrial fibrillation occurrence, except in patients with chronic kidney or pulmonary disease”.
- Chao T.-F.
- Liu C.-J.
- Chen S.-J.
- Wang K.-L.
- Lin Y.-J.
- Chang S.-L.
- et al.
The association between the use of non-steroidal anti-inflammatory drugs and atrial fibrillation: a nationwide case–control study.
Int J Cardiol. 2013; 168: 312-316
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to International Journal of Cardiology
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Cyclooxygenase-2 inhibitors and cardiovascular risk in a nation-wide cohort study after the withdrawal of rofecoxib.Eur Heart J. 2012; 33: 1928-1933
- Non-steroidal anti-inflammatory drug use and risk of atrial fibrillation or flutter: population based case-control study.BMJ. 2011; 343: d3450
- The association between the use of non-steroidal anti-inflammatory drugs and atrial fibrillation: a nationwide case–control study.Int J Cardiol. 2013; 168: 312-316
Personal correspondence. Erratum to confidence interval provided upon request by Dr. Tze-Fan Chao, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. September 26, 2014.
- Inter-relationships of atrial fibrillation and atrial flutter mechanisms and clinical implications.J Am Coll Cardiol. 2008; 51: 779-786
- Alcohol and risk of atrial fibrillation or flutter: a cohort study.Arch Intern Med. 2004; 164: 1993-1998
- Precision and statistics in epidemiologic studies. Modern Epidemiology. 3rd ed.Lippincott Williams & Wilkins, Philadelphia, PA2008
- A show of confidence.N Engl J Med. 1978; 299: 1362-1363
- Significance questing.Ann Intern Med. 1986; 105: 445-447
- Six persistent research misconceptions.J Gen Intern Med. 2014; 29: 1060-1064
Published online: October 07, 2014
Accepted: September 30, 2014
Received: September 30, 2014
© 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.