Adenosine is a nucleoside produced by ATP hydrolysis and released in the extracellular spaces during ischemia [
]. Adenosine is a coronary vasodilator [
- Eltzschig H.K.
- Bonney S.K.
- Eckle T.
Attenuating myocardial ischemia by targeting A2B adenosine receptors.
Trends Mol. Med. 2013; 19: 345-354
] that increases coronary blood flow via activation of adenosine A2A receptors (A2A R). Such coronary vasodilation constitutes therefore an adaptive response to the drop in O2 supply that occurs during hypoxemia or ischemia. During exercise stress testing (EST), myocardium O2 demand increases, which can lead to ischemia in patients with coronary artery disease (CAD). However despite being the most commonly used test to diagnose and follow patients with CAD, the predictive value of the treadmill test remains limited [
- Shryock J.C.
- Belardinelli L.
Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology.
Am. J. Cardiol. 1997; 79: 2-10
]. We examined whether the adenosine plasma concentration (APC) changes during EST in patients with or without coronary artery disease and whether the induced changes differ between positive and negative exercise tests. We also compared the expression of A2A R in both populations.
- Banerjee A.
- Newman D.R.
- Van den Bruel A.
- et al.
Diagnostic accuracy of exercise stress testing for coronary artery disease: a systematic review and meta-analysis of prospective studies.
Int. J. Clin. Pract. 2012; 66: 477-492
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- Attenuating myocardial ischemia by targeting A2B adenosine receptors.Trends Mol. Med. 2013; 19: 345-354
- Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology.Am. J. Cardiol. 1997; 79: 2-10
- Diagnostic accuracy of exercise stress testing for coronary artery disease: a systematic review and meta-analysis of prospective studies.Int. J. Clin. Pract. 2012; 66: 477-492
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Published online: November 11, 2014
Accepted: November 8, 2014
Received: November 7, 2014
© 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.