Adenosine is a nucleoside produced by ATP hydrolysis and released in the extracellular
spaces during ischemia [
[1]
]. Adenosine is a coronary vasodilator [
[2]
] that increases coronary blood flow via activation of adenosine A2A receptors (A2A R). Such coronary vasodilation constitutes therefore an adaptive response to the
drop in O2 supply that occurs during hypoxemia or ischemia. During exercise stress testing (EST),
myocardium O2 demand increases, which can lead to ischemia in patients with coronary artery disease
(CAD). However despite being the most commonly used test to diagnose and follow patients
with CAD, the predictive value of the treadmill test remains limited [
[3]
]. We examined whether the adenosine plasma concentration (APC) changes during EST
in patients with or without coronary artery disease and whether the induced changes
differ between positive and negative exercise tests. We also compared the expression
of A2A R in both populations.Keywords
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Article info
Publication history
Published online: November 11, 2014
Accepted:
November 8,
2014
Received:
November 7,
2014
Identification
Copyright
© 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
