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The Notch ligand Delta-like 1 is elevated and associated with mortality in patients with symptomatic aortic stenosis

  • Aurelija Abraityte
    Correspondence
    Corresponding author at: Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, P.B. 4950 Nydalen, 0424 Oslo, Norway.
    Affiliations
    Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    Faculty of Medicine, University of Oslo, Oslo, Norway

    Center for Heart Failure Research, University of Oslo, Oslo, Norway

    K.G. Jebsen Cardiac Research Center, University of Oslo, Oslo, Norway
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  • Lars Gullestad
    Affiliations
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    Faculty of Medicine, University of Oslo, Oslo, Norway

    Center for Heart Failure Research, University of Oslo, Oslo, Norway
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  • Erik Tandberg Askevold
    Affiliations
    Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    Center for Heart Failure Research, University of Oslo, Oslo, Norway

    Department of Medicine, Lovisenberg Diakonale Hospital, Oslo, Norway
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  • Ståle Nymo
    Affiliations
    Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    Faculty of Medicine, University of Oslo, Oslo, Norway
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  • Christen P. Dahl
    Affiliations
    Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    Center for Heart Failure Research, University of Oslo, Oslo, Norway
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  • Sven Aakhus
    Affiliations
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    Faculty of Medicine, University of Oslo, Oslo, Norway

    Center for Heart Failure Research, University of Oslo, Oslo, Norway
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  • Pål Aukrust
    Affiliations
    Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    Faculty of Medicine, University of Oslo, Oslo, Norway

    K. G. Jebsen Inflammation Research Center, University of Oslo, Oslo, Norway
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  • Thor Ueland
    Affiliations
    Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    Faculty of Medicine, University of Oslo, Oslo, Norway

    K.G. Jebsen Cardiac Research Center, University of Oslo, Oslo, Norway

    K. G. Jebsen Inflammation Research Center, University of Oslo, Oslo, Norway

    K. G. Jebsen Thrombosis Research and Expertise Center, University of Tromsø, Tromsø, Norway
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Published:November 18, 2014DOI:https://doi.org/10.1016/j.ijcard.2014.11.111
The Notch ligand Delta-like 1 is elevated and associated with mortality in patients with symptomatic aortic stenosis
Previous ArticleLow basal expression of A2A adenosine receptors and increase in adenosine plasma concentration are associated with positive exercise stress testing
Next ArticleThree-vessel coronary artery disease evaluation by multimodality imaging with near-infrared spectroscopy (NIRS) plus intravascular ultrasound (IVUS) and optical coherence tomography (OCT)
      Aortic valve stenosis (AS) is the most common cardiac valve disease in developed countries and its prevalence increases markedly with age [
      • Carabello B.A.
      Introduction to aortic stenosis.
      Circ. Res. 2013; 113: 179-185
      ]. The pathogenesis of AS is still not fully understood, but during disease progression, myofibroblast-like cells acquire osteoblastic features, including spontaneous calcification and bone formation that take place in the valves [
      • Rajamannan N.M.
      Calcific aortic stenosis: lessons learned from experimental and clinical studies.
      Arterioscler. Thromb. Vasc. Biol. 2009; 29: 162-168
      ]. Therapeutic strategies to delay the disease progression are lacking, and a better understanding of relevant signaling pathways could reveal new prognostic biomarkers and novel therapeutic targets in AS.

      Keywords

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      References

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        Introduction to aortic stenosis.
        Circ. Res. 2013; 113: 179-185
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        Calcific aortic stenosis: lessons learned from experimental and clinical studies.
        Arterioscler. Thromb. Vasc. Biol. 2009; 29: 162-168
        View in Article
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        Coordinating tissue interactions: notch signaling in cardiac development and disease.
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        J. Biol. Chem. 2005; 280: 15842-15848
        View in Article
        • Ueland T.
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        View in Article

      Article info

      Publication history

      Published online: November 18, 2014
      Accepted: November 16, 2014
      Received in revised form: November 10, 2014
      Received: September 15, 2014

      Identification

      DOI: https://doi.org/10.1016/j.ijcard.2014.11.111

      Copyright

      © 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.

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