Aortic valve stenosis (AS) is the most common cardiac valve disease in developed countries
and its prevalence increases markedly with age [
[1]
]. The pathogenesis of AS is still not fully understood, but during disease progression,
myofibroblast-like cells acquire osteoblastic features, including spontaneous calcification
and bone formation that take place in the valves [
[2]
]. Therapeutic strategies to delay the disease progression are lacking, and a better
understanding of relevant signaling pathways could reveal new prognostic biomarkers
and novel therapeutic targets in AS.Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to International Journal of CardiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Introduction to aortic stenosis.Circ. Res. 2013; 113: 179-185
- Calcific aortic stenosis: lessons learned from experimental and clinical studies.Arterioscler. Thromb. Vasc. Biol. 2009; 29: 162-168
- Coordinating tissue interactions: notch signaling in cardiac development and disease.Dev. Cell. 2012; 22: 244-254
- The role of notch pathway in cardiovascular diseases.Glob. Cardiol. Sci. Pract. 2013; 2013: 364-371
- Notch signaling in cardiovascular disease and calcification.Curr. Cardiol. Rev. 2008; 4: 148-156
- Mutations in NOTCH1 cause aortic valve disease.Nature. 2005; 437: 270-274
- Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling.J. Biol. Chem. 2005; 280: 15842-15848
- Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis.J. Intern. Med. 2010; 268: 483-492
Article info
Publication history
Published online: November 18, 2014
Accepted:
November 16,
2014
Received in revised form:
November 10,
2014
Received:
September 15,
2014
Identification
Copyright
© 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.