Timely performed reperfusion and adjuvant drug therapy are essential in the treatment of acute ST elevation myocardial infarction (STEMI). Reperfusion of the infarct-related artery (IRA) may, paradoxically, result in further injury of the ischemic myocardium by mechanisms collectively termed ischemia/reperfusion (I/R) injury [
]. Cardioprotection by ischemic postconditioning (IPost), performed by interrupted blood-flow to the ischemic myocardium at the time of reperfusion, has shown diverging effects on measures of infarct size and left ventricular (LV) function in clinical trials [
- Yellon D.M.
- Hausenloy D.J.
Myocardial reperfusion injury.
N. Engl. J. Med. 2007; 357: 1121-1135
]. Previous studies have shown good correlation between myocardial strain measured by 2-dimensional (2-D) speckle tracking echocardiography and infarct size and LV function [
- Abdelnoor M.
- Sandven I.
- Limalanathan S.
- Eritsland J.
Postconditioning in ST-elevation myocardial infarction: a systematic review, critical appraisal, and meta-analysis of randomized clinical trials.
Vasc. Health Risk Manag. 2014; 10: 477-491
]. Furthermore, post-systolic shortening has been suggested to be associated with ischemic segments with potential for recovery in patients with non-STEMI [
- Munk K.
- Andersen N.H.
- Terkelsen C.J.
- et al.
Global left ventricular longitudinal systolic strain for early risk assessment in patients with acute myocardial infarction treated with primary percutaneous intervention.
J. Am. Soc. Echocardiogr. 2012; 25: 644-651
]. However, little is known about a possible effect of IPost on myocardial strain in the acute stage of STEMI.
- Eek C.
- Grenne B.
- Brunvand H.
- et al.
Postsystolic shortening is a strong predictor of recovery of systolic function in patients with non-ST-elevation myocardial infarction.
Eur. J. Echocardiogr. 2011; 12: 483-489
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- Myocardial reperfusion injury.N. Engl. J. Med. 2007; 357: 1121-1135
- Postconditioning in ST-elevation myocardial infarction: a systematic review, critical appraisal, and meta-analysis of randomized clinical trials.Vasc. Health Risk Manag. 2014; 10: 477-491
- Global left ventricular longitudinal systolic strain for early risk assessment in patients with acute myocardial infarction treated with primary percutaneous intervention.J. Am. Soc. Echocardiogr. 2012; 25: 644-651
- Postsystolic shortening is a strong predictor of recovery of systolic function in patients with non-ST-elevation myocardial infarction.Eur. J. Echocardiogr. 2011; 12: 483-489
- Effect of ischemic postconditioning on infarct size in patients with ST-elevation myocardial infarction treated by primary PCI, results of the POSTEMI randomized trial.J. Am. Heart Assoc. 2014; 23: e000679
- Identification of acutely ischemic myocardium using ultrasonic strain measurements. A clinical study in patients undergoing coronary angioplasty.J. Am. Coll. Cardiol. 2003; 5: 810-819
- Rationale and design of the POSTEMI (POstconditioning in ST-Elevation Myocardial Infarction) Study.Cardiology. 2010; 116: 103-109
- Post-systolic shortening: a marker of potential for early recovery of acutely ischaemic myocardium in the dog.Cardiovasc. Res. 1987; 21: 703-716
- Does postsystolic motion or shortening predict recovery of myocardial function after primary percutaneous coronary intervention?.J. Am. Soc. Echocardiogr. 2007; 20: 505-511
- Segmental and global longitudinal strain and strain rate based on echocardiography of 1266 healthy individuals: the HUNT study in Norway.Eur. J. Echocardiogr. 2010; 11: 176-183
Published online: March 19, 2015
Accepted: March 17, 2015
Received: February 11, 2015
© 2015 Published by Elsevier Inc.