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Letter to the Editor| Volume 187, P60-62, May 06, 2015

Complete blood cell count risk score as a predictor of in-hospital mortality and morbidity among patients undergoing cardiac surgery with cardiopulmonary bypass

  • Ana Paula Porto Rödel
    Affiliations
    Cardiology Intensive Care, University Hospital, Federal University of Santa Maria, Santa Maria, RS, Brazil

    Laboratory of Clinical Biochemistry, Department of Clinical and Toxicological Analysis, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil

    Pharmaceutical Sciences Postgraduate Program, Center of Health Sciences, Federal University of Santaria, Santa Maria, RS, Brazil
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  • Manuela Borges Sangoi
    Affiliations
    Laboratory of Clinical Biochemistry, Department of Clinical and Toxicological Analysis, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil

    Pharmaceutical Sciences Postgraduate Program, Center of Health Sciences, Federal University of Santaria, Santa Maria, RS, Brazil
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  • Larissa Garcia de Paiva
    Affiliations
    School of Medicine, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil
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  • Jossana Parcianello
    Affiliations
    School of Medicine, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil
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  • José Edson Paz da Silva
    Affiliations
    Pharmaceutical Sciences Postgraduate Program, Center of Health Sciences, Federal University of Santaria, Santa Maria, RS, Brazil
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  • Rafael Noal Moresco
    Correspondence
    Corresponding author at: Universidade Federal de Santa Maria, Centro de Ciências da Saúde, Departamento de Análises Clínicas e Toxicológicas, Avenida Roraima 1000, Prédio 26, Sala 1401, Camobi, 97105-900, Santa Maria, RS, Brazil.
    Affiliations
    Laboratory of Clinical Biochemistry, Department of Clinical and Toxicological Analysis, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil

    Pharmaceutical Sciences Postgraduate Program, Center of Health Sciences, Federal University of Santaria, Santa Maria, RS, Brazil
    Search for articles by this author
Published:March 19, 2015DOI:https://doi.org/10.1016/j.ijcard.2015.03.227
Complete blood cell count risk score as a predictor of in-hospital mortality and morbidity among patients undergoing cardiac surgery with cardiopulmonary bypass
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      The preoperative estimation of individual risk in cardiac surgery (CS) is based on prediction models, such as the European System for Cardiac Operative Risk Evaluation (EuroSCORE) II [
      • Nashef S.A.M.
      • Roques F.
      • Sharples L.D.
      • Nilsson J.
      • Smith C.
      • Goldstone A.R.
      • et al.
      EuroSCORE II.
      Eur. J. Cardiothorac. Surg. 2012; 41: 734-744
      ], which requires software or internet access to perform their complex calculation. Most complications are attributable to the harmful effects of cardiopulmonary bypass (CPB) to blood cells, which are evaluated by routinely performed preoperative complete blood cell count (CBC-c). Changes in some parameters of CBC-c can increase the mortality rate by cardiac [
      • Dacey L.J.
      • DeSimone J.
      • Braxton J.H.
      • Leavitt B.J.
      • Lahey S.J.
      • Klemperer J.D.
      • et al.
      Preoperative white blood cell count and mortality and morbidity after coronary artery bypass grafting.
      Ann. Thorac. Surg. 2003; 76: 760-764
      ,
      • Benedetto U.
      • Angeloni E.
      • Melina G.
      • Pisano C.
      • Lechiancole A.
      • Roscitano A.
      • et al.
      Red blood cell distribution width predicts mortality after coronary artery bypass grafting.
      Int. J. Cardiol. 2013; 165: 369-371
      ] and no-cardiac [
      • Glance L.G.
      • Blumberg N.
      • Eaton M.P.
      • Lustik S.J.
      • Osler T.M.
      • Wissler R.
      • et al.
      Preoperative thrombocytopenia and postoperative outcomes after noncardiac surgery.
      Anesthesiology. 2014; 120: 62-75
      ] surgery. Some studies in the U.S. previously formulated and validated a CBC Risk Score (CBC-RS) [
      • Horne B.D.
      • Anderson J.L.
      • Muhlestein J.B.
      • Ridker P.M.
      • Paynter N.P.
      Complete blood count risk score and its components, including RDW, are associated with mortality in the JUPITER trial.
      Eur. J. Prev. Cardiol. 2015; 22: 519-526
      ,
      • Horne B.D.
      • May H.T.
      • Muhlestein J.B.
      • Ronnow B.S.
      • Lappé D.L.
      • Renlund D.G.
      • et al.
      Exceptional mortality prediction by risk scores from common laboratory tests.
      Am. J. Med. 2009; 122: 550-558
      ], which strongly predicted the risk of mortality in multiple sets of general medical patients. It can be automatically calculated using sex, age and CBC-c variables [
      • Horne B.D.
      • May H.T.
      • Muhlestein J.B.
      • Ronnow B.S.
      • Lappé D.L.
      • Renlund D.G.
      • et al.
      Exceptional mortality prediction by risk scores from common laboratory tests.
      Am. J. Med. 2009; 122: 550-558
      ]. We hypothesized that CBC-RS would be an easy, good predictor of in-hospital mortality and morbidity in patients who underwent CS with CPB.

      Keywords

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      References

        • Nashef S.A.M.
        • Roques F.
        • Sharples L.D.
        • Nilsson J.
        • Smith C.
        • Goldstone A.R.
        • et al.
        EuroSCORE II.
        Eur. J. Cardiothorac. Surg. 2012; 41: 734-744
        View in Article
        • Dacey L.J.
        • DeSimone J.
        • Braxton J.H.
        • Leavitt B.J.
        • Lahey S.J.
        • Klemperer J.D.
        • et al.
        Preoperative white blood cell count and mortality and morbidity after coronary artery bypass grafting.
        Ann. Thorac. Surg. 2003; 76: 760-764
        View in Article
        • Benedetto U.
        • Angeloni E.
        • Melina G.
        • Pisano C.
        • Lechiancole A.
        • Roscitano A.
        • et al.
        Red blood cell distribution width predicts mortality after coronary artery bypass grafting.
        Int. J. Cardiol. 2013; 165: 369-371
        View in Article
        • Glance L.G.
        • Blumberg N.
        • Eaton M.P.
        • Lustik S.J.
        • Osler T.M.
        • Wissler R.
        • et al.
        Preoperative thrombocytopenia and postoperative outcomes after noncardiac surgery.
        Anesthesiology. 2014; 120: 62-75
        View in Article
        • Horne B.D.
        • Anderson J.L.
        • Muhlestein J.B.
        • Ridker P.M.
        • Paynter N.P.
        Complete blood count risk score and its components, including RDW, are associated with mortality in the JUPITER trial.
        Eur. J. Prev. Cardiol. 2015; 22: 519-526
        View in Article
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        • May H.T.
        • Muhlestein J.B.
        • Ronnow B.S.
        • Lappé D.L.
        • Renlund D.G.
        • et al.
        Exceptional mortality prediction by risk scores from common laboratory tests.
        Am. J. Med. 2009; 122: 550-558
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      Article info

      Publication history

      Published online: March 19, 2015
      Accepted: March 17, 2015
      Received: February 25, 2015

      Identification

      DOI: https://doi.org/10.1016/j.ijcard.2015.03.227

      Copyright

      © 2015 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.

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