Ischemic heart disease remains a leading cause of morbidity and mortality worldwide.
Despite modern therapies, many patients still suffer from refractory angina pectoris
(RAP) therefore, alternative non-invasive revascularization methods are under development.
One of the methods stimulating angiogenesis is cardiac shock wave therapy (CSWT),
a new treatment method offering an alternative to revascularization. Recent studies
have demonstrated that the extracorporeal application of low-intensity shockwaves
to the myocardium may induce the release of angiogenesis-mediating growth factors
such as endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor
(VEGF), as well as induce the recruitment of endothelial progenitor cells [
1
,
2
,
3
,
4
]. This non-invasive treatment method has been used clinically and been shown to improve
symptoms and improve perfusion, however, limited data are available on the use of
multimodality imaging in patients undergoing this therapy [
5
,
6
,
7
]. The objective of the current study was to utilize multimodality imaging including
cardiac MRI for the selection of patients and evaluation of dynamic changes of LV
function during CSWT therapy.Keywords
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References
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Article info
Publication history
Published online: March 22, 2015
Accepted:
March 19,
2015
Received:
March 17,
2015
Footnotes
☆The authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.
☆☆Dr. Leibowitz has received minor consulting fees and travel expenses from Medispec LTD. (Manufacturer of CSWT equipment used). Medispec Ltd. has had no role in the funding or preparation of this manuscript. None of the other authors have any competing interests to report.
Identification
Copyright
© 2015 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
