Abstract
Introduction
The coincidental occurrence of a cardiac symptomatology (e.g. an acute coronary syndrome
or a myocardial infarction), during an anaphylactic or anaphylactoid episode is known
as Kounis Syndrome. A variety of drugs, substances, food and environmental exposures
are associated with this reaction. There is an exponential increase in the number
of published scientific articles reports on this syndrome, but since it is rare, the
largest case series published so far included only 10 and 6 patients.
Methods
We searched the global World Health Organization database called VigiBase™ to detect
all cases of Kounis Syndrome ever reported (last update December 31st 2014).
Results
We identified 51 cases of Kounis Syndrome reported to International Pharmacovigilance
Agency (VigiBase™). All these cases were reported in the period 2010–2014 and almost
half cases (22 reports) belonged to the year 2014. Most cases occurred in the USA
and non-steroidal anti-inflammatory drugs were the most frequent trigger drugs.
Discussion
We collected pharmacovigilance international data representing the largest case series
ever published on the recently identified Kounis Syndrome.
Keywords
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Article info
Publication history
Published online: October 13, 2015
Accepted:
October 3,
2015
Received in revised form:
September 22,
2015
Received:
July 27,
2015
Identification
Copyright
© 2015 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.