Patients with heart failure possess coagulation disorders and a risk of thromboembolic
events in the vascular system. This risk could potentially be derived from many sources
such as inflammation, neuro-hormonal activation, endothelial dysfunction, and stasis
[
1
,
2
]. D-dimer, a marker of fibrin turnover, is elevated where there is thrombus formation
and/or resolution in the circulatory system, and exhibits many interesting properties
as a biological marker of hemostatic abnormalities and thrombosis [
[3]
]. Previous studies have shown that elevated D-dimer levels are present in patients
with cardiovascular disease [
4
,
5
], and several studies have suggested that elevated D-dimer levels are associated with
long-term adverse outcomes in patients with established chronic and/or systolic heart
failure [
6
,
7
]. However, the short- and medium-term prognostic value of D-dimer levels on admission
in hospitalized patients with acute decompensated heart failure (ADHF) is not well
established. Therefore, this study aimed to analyze the in-hospital and medium-term
prognostic value of elevated D-dimer levels in patients who were admitted to a cardiac
intensive care unit with ADHF.Keywords
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References
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Article info
Publication history
Published online: November 23, 2015
Accepted:
November 22,
2015
Received:
November 15,
2015
Footnotes
☆These authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.
Identification
Copyright
© 2015 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
